Effects of depressive symptoms and routinization on metamemory during adulthood

The purpose of this study was to investigate the impact of aging, depressive symptoms and preference for routine on metamemory. Twenty-eight young adults (of mean age=20.7 years) and 28 older adults (68.5 years) completed the metamemory in adulthood (MIA) scale for assessing various metamemory dimensions. Compared with young adults, older adults used more external strategy. They used more internal strategy but only those with high depressive symptoms or high routinization. Older adults also reported a less efficient memory than young adults, showing less capacity and more change. In addition, depressive symptoms influenced many MIA subscales: participants with high depressive symptoms reported more external strategy use, less capacity, more change and less locus than participants with low depressive symptoms. Finally, highly routinized participants reported more use of external strategy and experienced more anxiety about memory. These results confirm the impact of aging on metamemory and show that an increase in depressive symptoms even without a depressive state and routinization also influences metamemory. This study shows the need to consider variables that modify memory perception during aging

Introduction : Framing community and spatial exclusion

This section focuses on the community and spatial aspects of social exclusion. For this introduction, we define spatial aspects of exclusion as the unintended reduction of mobility outside and inside of a person’s home and the community aspect of exclusion as the unintended reduction of participation in local life

Addressing the problem of plastic waste: Development of an enzymatic process for PET recycling

Every day, media and NGOs describe the society\u27s disaffection for plastics accused of polluting the planet. All major brand-owners made commitments to solve this problem (e.g. Coca-Cola, Nestlé, Danone, PepsiCo, Suntory, Unilever, L’Oréal, Nike) and announced a future with less plastic waste by 2025. Nevertheless, only 6 years before the announced term, no effective solution is yet available to meet these goals. Indeed, existing technologies like thermo-mechanical recycling leads to loss in mechanical properties of the polymer and even if several chemical recycling processes are under development, they suffer from the disadvantages of using organic solvents, high reaction temperatures and the need of an intensive waste sorting. Consequently, enzymatic recycling appears as a pertinent solution notably because the enzyme selectivity avoids a drastic sorting of waste and enables the recycling of complex plastics (multi-layers construction in some bottles of sparkling water for instance), it is an eco-friendly reaction in water and because of savings in energy consumption due to a low temperature of reaction. Using a computer-aided engineering strategy, we drastically improved the depolymerizing performance of the best identified enzyme candidate. Utilizing site-directed mutagenesis targeted at the active site, combined with three-dimensional fold stabilization, we engineered an enzyme variant, demonstrating an astounding increase in thermostability combined with a high activity. This enzyme is able to depolymerize 90% of PET waste (200g/kg) into monomers, terephthalic acid and ethylene glycol, in less than 10 hours. The downstream processing was developed and optimized leading to the demonstration that this enzymatic technology could enable the use of an industrial plastic waste to produce again PET monomers and ultimately a bottle from this recycled PET. We hope to demonstrate the strong potential of the enzymatic technology jointly developed by CARBIOS and LISBP to provide a breakthrough solution to help solve society’s growing plastic waste problem

Plasmodium Purine Metabolism and Its Inhibition by Nucleoside and Nucleotide Analogues

International audienceMalaria still affects around 200 million people and is responsible for more than 400,000 deaths per year, mostly children in subequatorial areas. This disease is caused by parasites of the Plasmodium genus. Only a few WHO-recommended treatments are available to prevent or cure plasmodial infections, but genetic mutations in the causal parasites have led to onset of resistance against all commercial antimalarial drugs. New drugs and targets are being investigated to cope with this emerging problem, including enzymes belonging to the main metabolic pathways, while nucleoside and nucleotide analogues are also a promising class of potential drugs. This review highlights the main metabolic pathways targeted for the development of potential antiplasmodial therapies based on nucleos(t)ide analogues, as well as the different series of purine-containing nucleoside and nucleotide derivatives designed to inhibit Plasmodium falciparum purine metabolism.

Community and spatial aspects of exclusion in later life

Everything that happens, happens somewhere, in some physical space. The socio-physical context, therefore, represents a basic framework for all social interactions. In an ideal world, everyday surroundings should be open, safe, barrier-free, inviting, aesthetic, green, healthy and pleasant, comfortable, both peaceful and entertaining, supportive, stimulating, and inclusive to all. Across the world, considerable energy, financial resources, planning and action has been invested to achieve such ideals. However, there are still groups and individuals who do not have the opportunity, agency, capital, or strength to enjoy what the given environment has to offer and/or, by various forces, experience a more restricted form of participation within these environments. People may be or may feel socially excluded by such spaces, places and communities, or be and feel excluded in the

Pet recycling: From enzyme and process optimization to an industrial plant

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An overview of current practices and approaches to co-designing services with and for people with dementia towards developing a framework for best practice

The aim of this paper is to provide an overview of current practices and approaches to co-designing services with and for people living with early to mid-stage dementia to derive a set of principles and practices for application in the IDoService project. It explores the understanding of service design and of co-design for the purposes of this paper, and then uses a meta-review of co-design of services for people with dementia, underpinned by a selection of case studies from the literature to extract and collate a set of key principles of best practice. We then consider the application of these principles and practices for the development of the IDoService to discuss implications and benefits of this approach for designing services

Ido Service project - work package one data

The IDoService project aimed to develop a special service to allow people living with mild to moderate dementia to plan, connect with and participate in tailored opportunities to realise themselves and continue to be fully part of society. It is made up of three stages, called Work Package 1, 2 and 3. This Open Access folder relates to Work Package 1. Work Package one (WP1) contains interviews and focus groups with the community. We conducted individual and group interviews with people living with mild to moderate dementia, their family and friends, and with other stakeholders in the field of dementia and meaningful activities. We discussed the availability, accessibility, needs, and wishes regarding social and leisure opportunities for people at early stages of dementia. The interviews were complimented by a literature review and an overview of local services offer and access support to them (e.g., financial support, specific transportation offer) regarding activities for people living with dementia in the Greater Manchester. The data collection provided a clear overview of the available opportunities regarding meaningful activities, and a working basis for the co-design workshops (work package 2)