Prostat adenokarsinomlarında IMP-3 ekspresyonunun araştırılması

Objective: Prostate cancer is the second most common cause of male cancer deaths after lung cancer in developed countries. The prognostic factors currently identified for prostate carcinoma include preoperative serum PSA, TNM staging system, histological grade and surgical margin status and are composed of the clinically most important and useful parameters. However, all the markers studied have not been applied in clinical practice. The oncofetal protein Insulin-Like Growth Factor II has been demonstrated to be associated with aggressive tumor behavior in many organs including urothelial tumors and renal cell carcinoma. Our aim was to investigate the expression status of Insulin-Like Growth Factor II in benign prostate glands, high grade PIN and prostate adenocarcinoma, and to determine the role of Insulin-Like Growth Factor II in pathogenesis of prostate adenocarcinoma. Material and Method: A total of 70 prostate adenocarcinoma cases accompanied by high grade PIN and benign prostate glands were evaluated by immunohistochemistry for the expression of Insulin-Like Growth Factor II. Results: Insulin-Like Growth Factor II expression was not seen in any of the 70 prostate adenocarcinoma and high grade PIN cases and benign prostate glands. Conclusion: Although the number of our cases was limited, our results suggested that Insulin-Like Growth Factor II protein expression was not included in the pathogenesis of the prostate adenocarcinomas and Insulin-Like Growth Factor II expression status cannot be used for diagnosis of prostate adenocarcinomas

FOXA1 is associated with high tumor grade, myometrial invasion and lymph node invasion in endometrial endometrioid carcinoma

Objectives: FOXA1 expression has been demonstrated in several hormone-dependent cancers. However, data are limited concerning the role of FOXA1 in endometrial cancers. The present study aimed to investigate FOXA1 expression via the microarray technique in benign hyperplasia, endometrial intraepithelial neoplasia, and endometrial endometrioid carcinoma. We also aimed to determine whether there were any associations between FOXA1 expression, tumor grade, myometrial invasion and lymphatic invasion.Material and methods: Paraffin-embedded sections prepared from samples obtained from 114 patients who underwent surgical hysterectomy or curettage were analyzed. Data were retrieved from digitally-stored medical records. Tissue microarrays were prepared from formalin-fixed, paraffin-embedded tissue blocks. Full tumor sections were used for immunohistochemical analysis performed.Results: Carcinomas with nuclear grade 3 had higher FOXA1 values than others, while grade 2 carcinomas also had higher FOXA1 values relative to grade 1 (p < 0.001). FOXA1 values of FIGO stage III carcinomas were significantly higher than others and stage II values were also significantly higher than stage I FOXA1 values (p < 0.001). Patients with myometrial and lymph node invasion had significantly higher FOXA1 values than others (p < 0.001 and p = 0.047, respectively). FOXA1 had 91.30% sensitivity, 63.60% specificity and 77.78% accuracy for predicting the presence of myometrial invasion with a cut-off value of 9.Conclusions: FOXA1 expression is higher in endometrial endometrioid carcinoma compared to benign endometrial hyperplasia or intraepithelial neoplasia. In patients with endometrial endometrioid carcinoma, high FOXA1 expression is associated with high tumor grade, myometrial and lymph node invasion. However, FOXA1 expression is not associated with lymphovascular or cervical invasion

Immunohistochemical expression of IMP3 in benign glandular structures, high grade prostatic intraepithelial neoplasia, and adenocarcinomas

Prostat adenokarsinomu, gelişmiş ülkelerde erkeklerde, en sık görülen kanserdir ve kansere bağlı ölümler sıralamasında akciğer kanserinden sonra ikinci sırada yer almaktadır. Günümüzde prostat adenokarsinomlarında tanımlanan prognostik faktörler içinde preoperatif serum PSA değeri, TNM sistemi esas alınarak evreleme, histopatolojik derece ve cerrahi sınırlar klinik olarak hasta takibinde en önemli ve faydalı parametreleri oluşturmakla birlikte, prostat adenokanserleriyle ilgili çalışmalarda kullanılan belirteçlerin hiçbirisi, klinik uygulamaya geçirilememiştir. Onkofetal bir protein olan IMP-3, mesane ve böbrek tümörlerini içeren birçok organda yapılan çalışmada agresif gidişli tümörlerle ilişkili bulunmuştur. Amacımız, benign prostatik glandlar, yüksek dereceli PIN ve prostat adenokarsinomlarında IMP-3 ekspresyon farkına bakarak, prostat adenokarsinomlarının patogenezindeki rolü aydınlatmaya çalışmaktır. Gruplar arasında ekspresyon yönünden anlamlı farklılık bulunduğu taktirde, IMP3'ün prostat adenokarsinomlarının gelişme sürecinde malign transformasyon açısından rutin uygulamada bir immünohistokimyasal belirleyici olabileceği düşünülmektedir. Bu çalışmada 70 adet prostat adenokarsinom olgusunda ve bunlara eşlik eden yüksek dereceli PIN alanları ile benign glandüler yapılar, immunohistokimyasal olarak IMP3 ekspresyonu açısından değerlendirildi. Çalışmada yer alan 70 adet prostat adenokarsinom olgusunda ve bunlara eşlik eden yüksek dereceli PIN alanları ile benign glandüler yapılarda IMP-3 ekspresyonu saptanmadı. Olgu sayımız sınırlı olmakla birlikte elde ettiğimiz bulgular, IMP-3 proteinin prostat adenokarsinomlarının patogenezinde yer almadığını ve IMP-3 ekspresyon durumunun prostat adenokarsinomlarında tanısal amaçlı kullanılamayacağını göstermektedir.Prostate cancer is the commonest cancer in developed countries in the men and is the second only to lung cancer as a cause of death. Today, prognostic factors identified in prostate carcinoma including preoperative serum PSA, TNM staging system, histological grade and surgical margin status are clinically the most important and useful parameters. However all of the markers used in studies of prostate cancers, has not been useful in clinical practice. An oncofetal protein IMP-3 has been demonstrated to be associated with aggressive tumor behavior at many organs including urothelial tumors and renal cell carcinoma. Our aim is to investigate the expression status of IMP-3 in benign prostate glands, high grade PIN and prostate adenocarcinoma, and to determine the role of the IMP-3 in pathogenesis of prostate adenocarcinoma. If there is significant difference in IMP-3 expression among these groups, it was thought that IMP-3 may have a role in the malignant transformation of prostate adenocarcinomas as an immunohistochemical marker. In this study, 70 prostate adenocarcinoma cases, accompanied with high grade PIN and benign prostate glands were evaluated by immunohistochemistry for the expression of IMP3. IMP3 expression was not seen in any of the 70 prostate adenocarcinoma, high grade PIN and benign prostate glands. Although the number of our cases was limited, our results suggested that IMP-3 protein expression was not included in the pathogenesis of the prostate adenocarcinomas and IMP-3 expression status cannot be used for diagnosis of prostate adenocarcinomas

A rare cause of intraabdominal tumor in childhood: Omental mesenteric myxoid hamartoma

Omental masses are rarely seen in childhood. Omental mesenteric myxoid hamartoma is a very rare and a new entity, first described by Gonzalez-Crussi et al. The tumor originates from the omentum and mesentery and presents as multiple nodules. It shares many morphologic features with inflammatory myofibroblastic tumor and therefore, may be considered as a variant of inflammatory myofibroblastic tumor. However, the clinical course and prognosis of this tumor is different. This rare and relatively new pathology in childhood, mimicking malign tumor and sharing many histopathological features with inflammatory myofibroblastic tumor, is presented to emphasize that it is a clinically different entity in terms of clinical picture and prognosis

Pediatric Infectious Diseases Society- Available online at www.cocukenfeksiyon.org

www.cocukenfeksiyon.org web sayfasından ulaşılabilir. DOI:10.5152/ced.2013.41 Acute infantile hemorrhagic edema (AIHE) is a benign form of cutaneous leukocytoclastic vasculitis that usually occurs in children younger than 2 years of age. Although the etiology is unknown, AIHE often follows infections, drug treatment, or vaccination. The onset of AIHE is often dramatic with petechiae, ecchymoses, and annular, nummular or targetoid purpuric lesions usually appearing on the extremities, face, or ears. In this report we aimed to present a case with AIHE in whomvaccination was considered the etiologic cause. (J Pediatr Inf 2014; 8: 40-3) Key words: Acute infantile hemorrhagic edema, leukocytoclastic vasculitis, immunizatio