The first and simple synthesis of indole alkaloid, bipolaramide

金沢大学大学院自然科学研究科生理活性物質科学金沢大学薬学部The first and simple total synthesis of bipolaramide was achieved in 31 % overall yield from (2S)-2,3-dihydroindole-2-carboxylic acid in three (or two) steps. Derivatives of bipolaramide having halogen, alkenyl, nitro, or azido substitueras were also prepared

A new and simple synthesis of 1-hydroxyindole derivatives

金沢大学大学院自然科学研究科生理活性物質科学金沢大学薬学

Rhe first total syntheses of 9-methoxycarbazole-3-carboxaldehyde and methoxybrassinin1 (the chemistry of 1-methoxyindole)

金沢大学大学院自然科学研究科生理活性物質科学金沢大学薬学

A simple synthesis of 7-substituted 1-acetyl-2,3-dihydroindoles

金沢大学大学院自然科学研究科生理活性物質科学金沢大学薬学

A simple synthesis of a phytoalexin, methoxybrassinin

金沢大学大学院自然科学研究科生理活性物質科学金沢大学薬学

New reactions thallium compounds : A simple synthesisi of 4-and 7-substituted indoles bearing a nitro or an azido group

金沢大学大学院自然科学研究科生理活性物質科学金沢大学薬学

Nucleophilic substitution reaction of 1-methoxy-6-nitro-indole

金沢大学大学院自然科学研究科生理活性物質科学金沢大学薬学部Nucleophilic substitution reaction of 1-methoxy-6-nitroindole (1) was examined. In the reaction with sodium methoxide or sodium cyanide as a nucleophile, 2- and 3-methoxy-6-nitroindoles, and 7-cyano-6-nitroindole were obtained, respectively. A novel methylene homologation at the 3-position was found in the reaction of 1 with sodium methyl sulfide or potassium salt of diethyl malonate to give 3-methylthiomethytyl-6-nitroindole and its 2-methylthio derivative, and diethyl 2-(6-nitroindol-3-yl)methylmalonate, respectively. Possible reaction mechanism is discussed

Frontal theta activation during motor synchronization in autism

Autism is characterized by two primary characteristics: deficits in social interaction and repetitive behavioral patterns. Because interpersonal communication is extremely complicated, its underlying brain mechanisms remain unclear. Here we showed that both characteristics can be explained by a unifying underlying mechanism related to difficulties with irregularities. To address the issues, we measured electroencephalographm during a cooperative tapping task, which required participants to tap a key alternately and synchronously with constant rhythmic a PC program, a variable rhythmic PC program, or a human partner. We found that people with autism had great difficulty synchronizing tapping behavior with others, and exhibited greater than normal theta-wave (6 Hz) activity in the frontal cortex during the task, especially when their partner behaved somewhat irregularly (i.e. a variable rhythmic PC program or a human partner). Importantly, the higher theta-wave activity was related to the severity of autism, not the performance on the task. This indicates that people with autism need to use intense cognition when trying to adapt to irregular behavior and can easily become overtaxed. Difficulty adapting to irregular behavior in others is likely related to their own tendencies for repetitive and regular behaviors. Thus, while the two characteristics of autism have been comprehended separately, our unifying theory makes understanding the condition and developing therapeutic strategies more tractable