Type-Ia Supernova Remnant Shell At Z=3.5Z=3.5 Seen In The Three Sightlines Toward The Gravitationally Lensed Qso B1422+231

Using the Subaru 8.2m Telescope with an IRCS Echelle spectrograph, we obtained high-resolution (R=10,000) near-infrared (1.01-1.38 \mu m) spectra of images A and B of the gravitationally lensed QSO B1422+231 (z=3.628) consisting of four known lensed images. We detected MgII absorption lines at z=3.54, which show a large variance of column densities (~ 0.3 dex) and velocities (~ 10 km/s) between the sightlines A and B with a projected separation of only 8.4h_{70}^{-1} pc at the redshift. This is the smallest spatial structure of the high-z gas clouds ever detected after Rauch et al. found a 20-pc scale structure for the same z=3.54 absorption system using optical spectra of images A and C. The observed systematic variances imply that the system is an expanding shell as originally suggested by Rauch et al. By combining the data for three sightlines, we managed to constrain the radius and expansion velocity of the shell (~ 50-100 pc, 130 km/s), concluding that the shell is truly a supernova remnant (SNR) rather than other types of shell objects, such as a giant HII region. We also detected strong FeII absorption lines for this system, but with much broader Doppler width than that of \alpha-element lines. We suggest that this FeII absorption line originates in a localized FeII-rich gas cloud that is not completely mixed with plowed ambient interstellar gas clouds showing other \alpha-element low-ion absorption lines. Along with the Fe richness, we conclude that the SNR is produced by an SNIa explosion.Comment: 16 pages, 15 figures, to be published in The Astrophysical Journa

Analysis of heat shock proteins and cytokines expressed during early stages of osteoarthritis in a mouse model

SummaryObjective:Osteoarthritis (OA) is a debilitating disease of the joints. The joints of affected individuals are characterized by a progressive degeneration of articular cartilage leading to inflammation and pain. The expression of heat shock proteins (HSPs) is a ubiquitous self-protective mechanism of all cells under stress, furthermore, the synovium of osteoarthritic individuals contains high levels of cytokines. This study seeks to establish the role of HSPs and cytokines in OA.Methods:We have investigated the presence of HSPs and cytokines in articular cartilage during early stages of OA in a mouse that is known to develop spontaneous OA lesions (C57 black mouse). The articular cartilage from closely related mice (C57BL/6) was used as control. Messenger RNAs (mRNAs) for HSPs (HSP32, HSP47, HSP60, HSP70, HSP84 and HSP86) and cytokines [interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ)] were detected by reverse transcription-polymerase chain reaction (RT-PCR).Results:The mRNA levels of HSP47, HSP70, HSP86, IL-6, and IFN-γ were up-regulated in the cartilage of C57 black mice, whereas, the level of expression of HSP32, HSP60, HSP84 and IL-1β remained unchanged. Furthermore, the expression of IL-1β, IL-6, TNF-α and IFN-γ mRNA was associated with expression of HSP60, HSP47, HSP70 and HSP70/HSP86 mRNA, respectively.Conclusions:The findings in this study suggest that chondrocytes are conditioned under non-physiological stress during early stages of OA, In addition, among HSPs, HSP70 was associated with two different highly expressed cytokines in C57 black mice, indicating the possible role of HSP70 as a characteristic indicator of early stage of OA

Solitary fibrous tumor of the buccal mucosa: A case report

Solitary fibrous tumors （SFTs） were reported in 1931 as tumors derived from mesenchymal tissue. They occur mainly in the pleura and peritoneum and rarely in the oral and maxillary regions. This report presents the case of a 48-year-old woman with a tumor in the left buccal mucosa. We suspected a salivary gland tumor or hemangioma. Excision was performed under general anesthesia. The lesion was removed as a single mass. Histopathological and immunohistochemical analyses led to the diagnosis of SFT. We report this case based on a literature review

Individual Consciousness and Community Activities

departmental bulletin pape

A low-frequency IL4R locus variant in Japanese patients with intravenous immunoglobulin therapy-unresponsive Kawasaki disease

Background: Kawasaki disease (KD) is a systemic vasculitis which may be associated with coronary artery aneurysms. A notable risk factor for the development of coronary artery aneurysms is resistance to intravenous immunoglobulin (IVIG) therapy, which comprises standard treatment for the acute phase of KD. The cause of IVIG resistance in KD is largely unknown; however, the contribution of genetic factors, especially variants in immune-related genes, has been suspected. Methods: To explore genetic variants related to IVIG-unresponsiveness, we designated KD patients who did not respond to both first and second courses of IVIG therapy as IVIG-unresponsive patients. Using genomic DNA from 30 IVIG-unresponsive KD patients, we performed pooled genome sequencing targeting 39 immune-related cytokine receptor genes. Results: The single nucleotide variant (SNV), rs563535954 (located in the IL4R locus), was concentrated in IVIG-unresponsive KD patients. Individual genotyping showed that the minor allele of rs563535954 was present in 4/33 patients with IVIG-unresponsive KD, compared with 20/1063 individuals in the Japanese genome variation database (odds ratio = 7.19, 95% confidence interval 2.43-21.47). Furthermore, the minor allele of rs563535954 was absent in 42 KD patients who responded to IVIG treatment (P = 0.0337), indicating that a low-frequency variant, rs563535954, is associated with IVIG-unresponsiveness in KD patients. Although rs563535954 is located in the 3'-untranslated region of IL4R, there was no alternation in IL4R expression associated with the mior allele of rs563535954. However, IVIG-unresponsive patients that exhibited the minor allele of rs563535954 tended to be classified into the low-risk group (based on previously reported risk scores) for prediction of IVIG-resistance. Therefore, IVIG-unresponsiveness associated with the minor allele of rs563535954 might differ from IVIG-unresponsiveness associated with previous risk factors used to evaluate IVIG-unresponsiveness in KD. Conclusion: These findings suggest that the SNV rs563535954 could serve as a predictive indicator of IVIG-unresponsiveness, thereby improving the sensitivity of risk scoring systems, and may aid in prevention of coronary artery lesions in KD patients.ArticlePEDIATRIC RHEUMATOLOGY.17:34(2019)journal articl