Prediction of phase separation in multi-component oxide glass for the fabrication of porous glass materials from waste slag

Published under licence in Journal of Physics: Conference Series by IOP Publishing Ltd

Grain boundary diffusion of W in lower mantle phase with implications for isotopic heterogeneity in oceanic island basalts by core-mantle interactions

Tungsten isotopes provide important constraints on the ocean-island basalt (OIB) source regions. Recent analyses of μ182W in modern basalts with high 3He/4He originating from the core-mantle boundary region reveal two distinct features: positive μ182W in Phanerozoic flood basalts indicating the presence of primordial reservoir, and negative μ182W in modern OIBs. One possibility to produce large variations in μ182W is interaction between the mantle and outer core. Here, we report grain boundary diffusion of W in lower mantle phases. High pressure experimental results show that grain boundary diffusion of W is fast and strongly temperature dependent. Over Earth's history, diffusive transport of W from the core to the lowermost mantle may have led to significant modification of the W isotopic composition of the lower mantle at length scales exceeding one kilometer. Such grain boundary diffusion can lead to large variations in μ182W in modern basalts as a function of the distance of their source regions from the core mantle boundary. Modern oceanic island basalts from Hawaii, Samoa and Iceland exhibit negative μ182W and likely originated from the modified isotope region just above the core-mantle boundary, whereas those with positive μ182W could be derived from the thick Large Low Shear Velocity Provinces (LLSVPs) far from the core-mantle boundary (CMB). When highly-oxidized slabs accumulate at the CMB oxidizing the outer core at the interface, a large W flux with negative μ182W can be added to the silicate mantle. As a result, the source region of the OIB would be effectively modified to a negative μ182W

An Orthogonalized Valence Orbital Approximation in Relativistic Full-Potential Linear-Combination-of-Atomic-Orbitals Methods

An approximation for reducing the computational cost in fully relativistic and scalar relativistic full-potential linear-combination-of-atomic-orbitals (LCAO) methods is introduced. The basic idea is the same as in the orthogonalized plane wave method; valence orbitals are orthogonalized to core orbitals and, using the orthogonalized valence orbitals as the basis functions in the generalized eigenvalue problem, the size of matrices is reduced considerably for materials with heavy atoms. This enables us to calculate their structural and electronic properties efficiently. The usefulness of the orthogonalized valence orbital approximation is shown by applying it to Au, InSb, and AmBi. In particular, it is found that the effect of spin–orbit coupling is reproduced successfully in the fully relativistic full-potential LCAO calculations within the orthogonalized valence orbital approximation

H. pylori-Eradication Therapy Increases RUNX3 Expression in the Glandular Epithelial Cells in Enlarged-Fold Gastritis

Helicobacter pylori (HP)-eradication therapy increases Runt domain transcription factor 3 (RUNX3) expression in the glandular epithelial cells in enlarged-fold gastritis. The aim of this study is to evaluate expression of the RUNX3 protein, the product of a gastric tumor suppression gene, and mutagenic oxidative stress in human gastric mucosal specimens obtained from patients with HP-induced enlarged-fold gastritis. Methods. RUNX3 expression was immunohistochemically scored and the degree of the mucosal oxidative stress was directly measured by the chemiluminescense (ChL) assay in the biopsy specimens. Results. RUNX3 expression was detected in the gastric epithelial cells. HP-eradication significantly increased RUNX3 expression in the glandular epithelium of the corpus, however, no change was observed in those of the antrum. A fourfold higher mucosal ChL value was observed in the corpus as compared with that in the antrum. HP-eradication significantly decreased the mucosal ChL values in both portions of the stomach to nearly undetectable levels. Conclusion. The glandular epithelium is exposed to a high level of carcinogenic oxidative stress and shows low levels of expression of the tumor suppressive molecule, RUNX3; however, this expression was restored after HP-eradication, suggesting the high risk of carcinogenesis associated with HP-induced enlarged-fold gastritis of the corpus