The supposition of the mechanism of escitalopram makes a dopamine nerve activity rise by inhibiting corticotropinreleasing factor to the non-organic-pain ～A SSRI application is desirable for a non-organic-pain～

Although escitalopram (ESC) is no having dopamine (DA) transporter (DAT) inhibitory-action, having dopamine nerve (A10 nerve) stimulus operation by the ESC used basic experiment is reported. We supposed the mechanism that the DA increases and it supposed the mechanism that makes a non-organic pain disappear with ①5-HT reinforcement of the descending pain modulatory system, ②the opioid receptor activation with the descending pain modulatory system, ③negative emotion block from the amygdala and the hippocampus to the nucleus accumbens, ④5-HT1A receptor stimulation from the activation of the amygdala, ⑤DA-phasic activity activation. As a result ④ and ⑤ two items were an operation with a main restraint mechanism of a nonorganic-pain. ESC is different from other SSRIs, and we know that ESC make a DA increase at the VTA. We supposed amygdala that a functional depression declined by corticotropin-releasing factor (CRF) is improved with ④ and ③. After DA stimulate by A10 nerve, DA is undergone metabolic change to, and the endogenous opioid peptide (βendorphin) is made

The Supposition of the Mechanism of SSRI to the glossodynia as Non-Organic-Pain in the Mouth and Face Area

These contents obtain the approval of Japanese Red Cross Takayama Hospital Ethics Committeeand it is considering sufficiently about the ethical models such as the protection of the privacy.There is not a state of the conflict of interests (COI)

The Early Effect Onset of SSRI to the Non-Organic-Pain in the Mouth and Face Area

These contents obtain the approval of Japanese Red Cross Takayama Hospital Ethics Committeeand it is considering sufficiently about the ethical models such as the protection of the privacy.There is not a state of the conflict of interests (COI )

ジュツゼン シンダンシエタ タンノウ ネンテンショウ ノ 1レイ

We report on a case of torsion of the gallbladder, whitch was correctly diagnosed preoperatively using pre-operative imaging with ultrasound and computed tomography. A 88-year-old woman was admitted to the hospital because of diarrhea and fever. Increased levels of WBC, CRP were noted in laboratory test. An Abdominal ultrasound showed a swollen gallbladder with a thicked wall in the body and funds, floating gallbladder and a high echo level lesion with an acoustic shadow in the gallbladder. Abdominal computed tomography showed a gallbladder with a spirally twisted neck and small gass lesion. Diagnostic imaging demonstrated acute inflammatory changes in the gallbladder with an abnormal arrangement of the gallbladder. These results suggested necrotizing cholecystitis with tortion of the gallbladder. During the operation, the gallbladder was found to be enlarged and twisted 360 degrees in a clockwise direction at the neck of the gallbladder, resulting in gangrenous change. A cholecystectomy was successfully performed and the patient was discharged in good condition, 23 days after the operation