Repulsion and absorption of the Σ\Sigma-nucleus potential for Σ−\Sigma^--5^5He in the 6^6Li(π−\pi^-, K+K^+) reaction

We study phenomenologically inclusive spectra of the $^6$Li($\pi^-$, $K^+$) reaction at 1.2 GeV/$c$ within a distorted-wave impulse approximation with the optimal Fermi-averaging $\pi^- p \to K^+ \Sigma^-$ $t$ matrix. We attempt to clarify the property of a $\Sigma$-nucleus potential for $\Sigma^-$-$^5$He by comparing the calculated spectra with the data of the J-PARC E10 experiment. The result shows that the repulsive and absorptive components of the $\Sigma^-$-$^5$He potential provide the ability to explain the data of the continuum spectra in $\Sigma$ and $\Lambda$ regions; the strengths of $V_\Sigma \simeq$ +30 MeV and $W_\Sigma \simeq$ $-$26 MeV are favored within the Woods-Saxon potential, consistent with analyses for heavier nuclei. Effects of the size and potential range for $\Sigma^-$-$^5$He in the neutron excess of $(N-Z)/(N+Z)=$ 0.2 are also discussed.Comment: 35 pages, 11 figure

Biologically active fibroblast growth factor 1 tagged with various epitopes

<p>Abstract</p> <p>Background</p> <p>Fibroblast growth factor (FGF) family members are involved in the regulation of a variety of biological phenomena. Because most of their activity is exerted via a signaling complex composed of FGF, heparin/heparan sulfate and FGF receptor tyrosine kinase, it is important to study the dynamic behavior of all the molecules in the complex without disturbing their interaction or activity.</p> <p>Findings</p> <p>We used <it>E. coli </it>to express biologically active human FGF1 tagged at its C-terminus with myc-(His)₆, V5-(His)₆or 3xFLAG-(His)₆. We found that the tagged FGF1s had affinities for heparin that were similar to that of the native form. The tagged FGF1s also exhibited mitogenic activity similar to that of the native form. Apparently, the tags do not interfere with the formation of the three-member complex involving FGF1, FGF receptor and heparan sulfate/heparin.</p> <p>Conclusion</p> <p>Tagged FGF1s should be useful for investigating the dynamic behavior of FGF1 in the context of its three-member signaling complex and other molecular complexes.</p

Behavioral Analysis of Genetically Modified Mice Indicates Essential Roles of Neurosteroidal Estrogen

Aromatase in the mouse brain is expressed only in the nerve cells of specific brain regions with a transient peak during the neonatal period when sexual behaviors become organized. The aromatase-knockout (ArKO) mouse, generated to shed light on the physiological functions of estrogen in the brain, exhibited various abnormal behaviors, concomitant with undetectable estrogen and increased androgen in the blood. To further elucidate the effects of neurosteroidal estrogens on behavioral phenotypes, we first prepared an brain-specific aromatase transgenic (bsArTG) mouse by introduction of a human aromatase transgene controlled under a −6.5 kb upstream region of the brain-specific promoter of the mouse aromatase gene into fertilized mouse eggs, because the −6.5 kb promoter region was previously shown to contain the minimal essential element responsible for brain-specific spatiotemporal expression. Then, an ArKO mouse expressing the human aromatase only in the brain was generated by crossing the bsArTG mouse with the ArKO mouse. The resulting mice (ArKO/bsArTG mice) nearly recovered from abnormal sexual, aggressive, and locomotive (exploratory) behaviors, in spite of having almost the same serum levels of estrogen and androgen as the adult ArKO mouse. These results suggest that estrogens locally synthesized in the specific neurons of the perinatal mouse brain directly act on the neurons and play crucial roles in the organization of neuronal networks participating in the control of sexual, aggressive, and locomotive (exploratory) behaviors

精神分裂病における言語性幻聴の消失過程: その自己所属性、自主性を中心にした精神病理学的研究

取得学位 : 博士（医学）, 学位授与番号 : 医博乙第1283号,学位授与年月日：平成6年3月16日,学位授与年：199

Leisure-time, occupational, and commuting physical activity and risk of type 2 diabetes in Japanese workers: a cohort study

Table S1. Association between moderate-intensity and vigorous-intensity exercise during leisure and risk of type 2 diabetes. Table S2. Risk of type 2 diabetes associated with specific type of leisure-time exercise. (DOCX 47 kb

jaw osteonecrosis risk in hip fractures

Purpose : Antiresorptive agents, such as bisphosphonates, are useful for the prevention of the recurrence of hip fractures. However, their administration has a risk of antiresorptive agent-related osteonecrosis of the jaw (ARONJ), and risk factors include poor oral hygiene. It is difficult for an orthopedic surgeon to examine a patient’s oral condition thoroughly. This study evaluated the relationship between risk factors for ARONJ and intraoral findings in hip fracture patients. Materials and Methods : We evaluated 79 patients (average age of 82.2 years) with hip fracture surgery who underwent an oral assessment by dentists. The risk assessments of the intraoral findings were classified into four levels (levels 0-3), with levels 2 and 3 requiring dental treatment intervention. Data that could be extracted as risk factors of ARONJ were also examined. Results : Level 1 was found most frequently (54.4%), followed by level 0 (35.4%), level 2 (8.9%), level 3 (1.3%). The area under the receiver operating characteristic curve for the number of risk factors for the two groups (dental treatment intervention required and unnecessary) and oral findings were 0.732. When the cut-off value was set to two risk factors, the specificity and sensitivity was 53.5% and 87.5%. Conclusions : For hip fracture patients with a more than 2 risk factors, dental visits are recommended to prevent ARONJ. This is a useful evaluation method that can be used to screen for ONJ from data obtained from other risk factors, even if it is difficult to evaluate the oral condition in hospitals where dentists are absent

Implementation of a new specific program for training curators at Hiroshima University

博物館法施行規則の改正に伴い，2012年4月から学芸員資格取得のために修得すべき科目が大幅に変更となった。学芸員資格取得の歴史においてはきわめて大きな変更である。本学では，これに対応するため，各学部の学芸員資格取得特定プログラムを統合し，全学の学生を対象とする新課程に移行した。本稿では，本学が新たに採用した4学期制（ターム制）を含め，今回の変更が受講や資格取得にどのような影響を及ぼしたのか，統計データの分析を通じて考察した。新課程移行の前後で，プログラム登録者数，資格取得者数は大幅に減少し，取得率も大きく低下した。こうした現象は特定の学部，分野の変化に基づくものではなく，旧課程においてプログラム登録の主体となってきた全ての学部に共通する。分析を通じて，大幅な必要単位数の増加，全学を対象としたプログラムへの変更，2学期制から4学期制（ターム制）への変更など，複数の要因が関連して，各学部における専門の修得と学芸員資格取得を両立させることが困難な状況が生じていることが推定された。As a result of the revision of Museum Law Enforcement Rules, the subjects that must be completed to acquire the curator qualification have changed significantly since April 2012, which constitutes a major change in the history of this qualification. To cope with this change, we integrated the curator qualification specific programs of each faculty into a new course for students of all universities. In this paper, through statistical data analysis, we examined the impact of this change on attendance trends, including the term system newly adopted by Hiroshima University. Before and after the transition to the new course, the number of program registrants and qualifications greatly decreased, and the acquisition rate has also declined significantly. These phenomena were not based on changes in specific faculties or fields, but are common to all faculties subject to program registration during the old course. Through this analysis, we presumed that several factors, such as the great increase in the required number of credits, the change to the program for the whole school, and the change from a two-semester system to the four-semester system, were all interrelated to each other, which make it difficult to achieve both specialized and curator qualifications.本稿は，2018年6月22日に香川大学で開催された第13回日本博物科学会で口頭発表した藤野次史・青木孝夫・清水則雄・菅村 亨・本多博之・山口富美夫・山崎博史・吉田将之「広島大学における新課程実施後の学芸員資格取得状況について」を元に，新たなデータを加えて考察したものである