Una Aproximación al Sistema de Numeración Decimal en Transición

Esta comunicación está basada en los resultados del trabajo de investigación enfocado en caracterizar elementos conceptuales y procedimentales sobre la construcción del Sistema de Numeración Decimal (SND) en Transición, mediante una propuesta de aula que involucra los conceptos de Orden, Cardinalidad y Agrupación. Esta propuesta se fundamenta en el marco teórico y metodológico de los Modelos Teóricos Locales (Filloy, 1999), a través de cuatro componentes interrelacionados (Cognición, Comunicación, Enseñanza y Formal), los cuales, se consolidan en la realización de la propuesta de aula y en la realización de un estudio de casos. La implementación y el análisis de los resultados muestran que los estudiantes se apropian de diferentes conceptos relacionados con el SND como la correspondencia uno a uno, el cardinal, las agrupaciones de diez, la composición y descomposición de cantidades, la realización de cambios con unidades de orden inferior a unidades de orden superior y las relaciones de orden

A New Look At Carbon Abundances In Planetary Nebulae. IV. Implications For Stellar Nucleosynthesis

This paper is the fourth and final report on a project designed to study carbon abundances in a sample of planetary nebulae representing a broad range in progenitor mass and metallicity. We present newly acquired optical spectrophotometric data for three Galactic planetary nebulae IC 418, NGC 2392, and NGC 3242 and combine them with UV data from the IUE Final Archive for identical positions in each nebula to determine accurate abundances of He, C, N, O, and Ne at one or more locations in each object. We then collect abundances of these elements for the entire sample and compare them with theoretical predictions of planetary nebula abundances from a grid of intermediate mass star models. We find some consistency between observations and theory, lending modest support to our current understanding of nucleosynthesis in stars below 8 M_o in birth mass. Overall, we believe that observed abundances agree with theoretical predictions to well within an order of magnitude but probably not better than within a factor of 2 or 3. But even this level of consistency between observation and theory enhances the validity of published intermediate-mass stellar yields of carbon and nitrogen in the study of the abundance evolution of these elements.Comment: 41 pages, 11 figures. Accepted for publication in the Astrophysical Journa

The knowledge transfer process in Six Sigma subsidiary firms

Although the operative benefits of Six Sigma methodology in the business world are well accepted, the long-term benefits of the initiative are currently under discussion. This paper aims to analyze how Six Sigma methodology is related to the knowledge transfer process, a source of competitive advantage. For this purpose, we observe how team management in Six Sigma firms differs statistically from team management proposed by other quality management initiatives, and how Six Sigma team management is related to the knowledge integration and knowledge transfer processes. An ANOVA analysis and Partial Least Squares (PLS) approach were used to analyze data from 53 European Six Sigma firms, confirming the hypotheses developed. The results confirm that Six Sigma methodology offers new possibilities to companies and that implementation of Six Sigma has a positive effect on variables that influence long-term organizational performance, such as knowledge management. Relevant academic contributions and implications for practitioners are included.This work was supported by the Spanish Ministry of Science and Innovation (Projects ECO2010-15885; ECO2013-47027P), Junta de Andalucia (P11-SEJ-7294) and the European Union (European Regional Development Funds)

Ongoing Phase 1/2 Study Of Incb050465, A Selective Pi3kδ Inhibitor, For The Treatment Of Patients (Pts) With Relapsed/Refractory (R/R) B‐Cell Malignancies (Citadel‐101)

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/137307/1/hon2438_139.pd

Association between IL-18 gene polymorphisms and biopsy-proven giant cell arteritis

7 pages, 1 figure, 1 table.-- Research article.[Introduction] The objective was to investigate the potential implication of the IL18 gene promoter polymorphisms in the susceptibility to giant-cell arteritis (GCA).[Methods] In total, 212 patients diagnosed with biopsy-proven GCA were included in this study. DNA from patients and matched controls was obtained from peripheral blood. Samples were genotyped for the IL18-137 G>C (rs187238), the IL18-607 C>A (rs1946518), and the IL18-1297 T>C (rs360719) gene polymorphisms with polymerase chain reaction, by using a predesigned TaqMan allele discrimination assay.[Results] No significant association between the IL18-137 G>C polymorphism and GCA was found. However, the IL18 -607 allele A was significantly increased in GCA patients compared with controls (47.8% versus 40.9% in patients and controls respectively; P = 0.02; OR, 1.32; 95% CI, 1.04 to 1.69). It was due to an increased frequency of homozygosity for the IL18 -607 A/A genotype in patients with GCA (20.4%) compared with controls (13.4%) (IL18 -607 A/A versus IL18 -607 A/C plus IL18 -607 C/C genotypes: P = 0.04; OR, 1.59; 95% CI, 1.02 to 2.46). Also, the IL18-1297 allele C was significantly increased in GCA patients (30.7%) compared with controls (23.0%) (P = 0.003; OR, 1.48; 95% CI, 1.13 to 1.95). In this regard, an increased susceptibility to GCA was observed in individuals carrying the IL18-1297 C/C or the IL18-1297 C/T genotypes compared with those carrying the IL18-1297 T/T genotype (IL18-1297 C/C plus IL18-1297 T/C versus IL18-1297 T/T genotype in GCA patients compared with controls: P = 0.005; OR, 1.61; 95% CI, 1.15 to 2.25). We also found an additive effect of the IL18 -1297 and -607 polymorphisms with TLR4 Asp299Gly polymorphism. The OR for GCA was 1.95 for combinations of genotypes with one or two risk alleles, whereas carriers of three or more risk alleles have an OR of 3.7.[Conclusions] Our results show for the first time an implication of IL18 gene-promoter polymorphisms in the susceptibility to biopsy-proven GCA. In addition, an additive effect between the associated IL18 and TLR4 genetic variants was observed.This study was supported by a grant from Fondo de Investigaciones Sanitarias PI06-0024 (Spain) and in part by Junta de Andalucía, grupo CTS-180 (Spain). This work was partially supported by the RETICS Program, RD08/0075 (RIER), from Instituto de Salud Carlos III (ISCIII).Peer reviewe

In planta expression of human polyQ-expanded huntingtin fragment reveals mechanisms to prevent disease-related protein aggregation

In humans, aggregation of polyglutamine repeat (polyQ) proteins causes disorders such as Huntington’s disease. Although plants express hundreds of polyQ-containing proteins, no pathologies arising from polyQ aggregation have been reported. To investigate this phenomenon, we expressed an aggregation-prone fragment of human huntingtin (HTT) with an expanded polyQ stretch (Q69) in Arabidopsis thaliana plants. In contrast to animal models, we find that Arabidopsis sp. suppresses Q69 aggregation through chloroplast proteostasis. Inhibition of chloroplast proteostasis diminishes the capacity of plants to prevent cytosolic Q69 aggregation. Moreover, endogenous polyQ-containing proteins also aggregate on chloroplast dysfunction. We find tha

Green function techniques in the treatment of quantum transport at the molecular scale

The theoretical investigation of charge (and spin) transport at nanometer length scales requires the use of advanced and powerful techniques able to deal with the dynamical properties of the relevant physical systems, to explicitly include out-of-equilibrium situations typical for electrical/heat transport as well as to take into account interaction effects in a systematic way. Equilibrium Green function techniques and their extension to non-equilibrium situations via the Keldysh formalism build one of the pillars of current state-of-the-art approaches to quantum transport which have been implemented in both model Hamiltonian formulations and first-principle methodologies. We offer a tutorial overview of the applications of Green functions to deal with some fundamental aspects of charge transport at the nanoscale, mainly focusing on applications to model Hamiltonian formulations.Comment: Tutorial review, LaTeX, 129 pages, 41 figures, 300 references, submitted to Springer series "Lecture Notes in Physics