Radiation and Stemness Phenotype May Influence Individual Breast Cancer Outcomes: The Crucial Role of MMPs and Microenvironment

Breast cancer is the most common cancer in women. Radiotherapy (RT) is one of the mainstay treatments for cancer but in some cases is not effective. Cancer stem cells (CSCs) within the tumor can be responsible for recurrence and metastasis after RT. Matrix metalloproteases (MMPs), regulated mainly by tissue inhibitors of metalloproteinases (TIMPs) and histone deacetylases (HDACs), may also contribute to tumor development by modifying its activity after RT. The aim of this work was to study the effects of RT on the expression of MMPs, TIMPs and HDACs on different cell subpopulations in MCF-7, MDA-MB-231 and SK-BR-3 cell lines. We assessed the in vitro expression of these genes in different 3D culture models and induced tumors in female NSG mice by orthotopic xenotransplants. Our results showed that gene expression is related to the cell subpopulation studied, the culture model used and the single radiation dose administered. Moreover, the crucial role played by the microenvironment in terms of cell interactions and CSC plasticity in tumor growth and RT outcome is also shown, supporting the use of higher doses (6 Gy) to achieve better control of tumor developmentThis research was funded by the FUNDACIÓN PROGRESO Y SALUD, Consejería de Igualdad, Salud y Políticas Sociales, Junta de Andalucía (PI-730), the INSTITUTO DE SALUD CARLOS III, Ministerio de Ciencia, Innovación y Universidades (PIE16-00045) and by the Chair “Doctors Galera-Requena in cancer stem cell research” (CMC-CTS963)

Guia d'intervenció grupal psicoeducativa en atenció primària

Atenció primària de salut; Formació psicoeducativa; Activitat grupal psicoeducativaPrimary health care; Psychoeducational training; Psychoeducational group activityAtención primaria de salud; Formación psicoeducativa; Actividad grupal psicoeducativaL'objectiu principal d´aquest document és actualitzar les guies de referència per dur a terme intervencions psicoeducatives grupals, i proporcionar una guia pels professionals sanitaris d'atenció primària.The main objective of this document is to update the reference guides to carry out group psychoeducational interventions, and to provide a guide for primary care health professionals.El objetivo principal de este documento es actualizar las guías de referencia para llevar a cabo intervenciones psicoeducativas grupales, y proporcionar una guía para los profesionales sanitarios de atención primaria.:e

Construyendo una identidad corporativa digital: la biblioteca/CRAI de la Universidad Pablo de Olavide en los medios sociales

The Library/CRAI of the University Pablo de Olavide left its digital imprint for the first time in the social media in 2010. Since then, its presence in these networks has become stronger. Its main aim is to bring their products and services closer to the university community, and try to adapt them to their needs. At the same time, the Library is building up its digital identity step by step. In this paper we describe the history and experience in the different social networks, which foster content and cooperative spaces. We offer some examples and data that show the evolution of their results.La Biblioteca/CRAI de la Universidad Pablo de Olavide dejó su huella digital por primera vez en los medios sociales en al año 2010. Desde entonces ha ido consolidando su presencia en ellos con el objetivo fundamental de acercar sus productos y servicios a la comunidad universitaria e intentar adaptarlos a sus necesidades. Al mismo tiempo va construyendo paso a paso su identidad digital. Se describe el camino recorrido y la experiencia en las distintas redes sociales, agregadores de contenido y espacios de colaboración. Se aportan ejemplos y datos que muestran la evolución de sus resultados

The on-ground data reduction and calibration pipeline for SO/PHI-HRT

The ESA/NASA Solar Orbiter space mission has been successfully launched in February 2020. Onboard is the Polarimetric and Helioseismic Imager (SO/PHI), which has two telescopes, a High Resolution Telescope (HRT) and the Full Disc Telescope (FDT). The instrument is designed to infer the photospheric magnetic field and line-of-sight velocity through differential imaging of the polarised light emitted by the Sun. It calculates the full Stokes vector at 6 wavelength positions at the Fe I 617.3 nm absorption line. Due to telemetry constraints, the instrument nominally processes these Stokes profiles onboard, however when telemetry is available, the raw images are downlinked and reduced on ground. Here the architecture of the on-ground pipeline for HRT is presented, which also offers additional corrections not currently available on board the instrument. The pipeline can reduce raw images to the full Stokes vector with a polarimetric sensitivity of 10−3⋅Ic or better.Sección Deptal. de Óptica (Óptica)Fac. de Óptica y OptometríaTRUEBMWi - Bundesministerium für Wirtschaft und Energie (Alemania)MPG - Max-Planck-Gesellschaft (Alemania)Ministerio de Ciencia e Innovación de España - MCIUInstituto de Astrofísica de Andalucía - CSIC (España)CNES - Centre National d'études spatiales (Francia)Fondos FEDERAgencia Estatal de Investigación - AEI (ESpaña)pu