The role of the particle aspect ratio in the discharge of a narrow silo

The time evolution of silo discharge is investigated for different granular materials made of spherical or elongated grains in laboratory experiments and with discrete element model (DEM) calculations. For spherical grains, we confirm the widely known typical behavior with constant discharge rate (except for initial and final transients). For elongated particles with aspect ratios between 2 < L/d < 6.1, we find a peculiar flow rate increase for larger orifices before the end of the discharge process. While the flow field is practically homogeneous for spherical grains, it has strong gradients for elongated particles with a fast-flowing region in the middle of the silo surrounded by a stagnant zone. For large enough orifice sizes, the flow rate increase is connected with a suppression of the stagnant zone, resulting in an increase in both the packing fraction and flow velocity near the silo outlet within a certain parameter range

The role of the particle aspect ratio in the discharge of a narrow silo

The time evolution of silo discharge is investigated for different granular materials made of spherical or elongated grains in laboratory experiments and with discrete element model (DEM) calculations. For spherical grains, we confirm the widely known typical behavior with constant discharge rate (except for initial and final transients). For elongated particles with aspect ratios between 2 < L/d < 6.1, we find a peculiar flow rate increase for larger orifices before the end of the discharge process. While the flow field is practically homogeneous for spherical grains, it has strong gradients for elongated particles with a fast-flowing region in the middle of the silo surrounded by a stagnant zone. For large enough orifice sizes, the flow rate increase is connected with a suppression of the stagnant zone, resulting in an increase in both the packing fraction and flow velocity near the silo outlet within a certain parameter range

Complement lectin pathway activation is associated with COVID-19 disease severity, independent of MBL2 genotype subgroups

IntroductionWhile complement is a contributor to disease severity in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, all three complement pathways might be activated by the virus. Lectin pathway activation occurs through different pattern recognition molecules, including mannan binding lectin (MBL), a protein shown to interact with SARS-CoV-2 proteins. However, the exact role of lectin pathway activation and its key pattern recognition molecule MBL in COVID-19 is still not fully understood.MethodsWe therefore investigated activation of the lectin pathway in two independent cohorts of SARS-CoV-2 infected patients, while also analysing MBL protein levels and potential effects of the six major single nucleotide polymorphisms (SNPs) found in the MBL2 gene on COVID-19 severity and outcome.ResultsWe show that the lectin pathway is activated in acute COVID-19, indicated by the correlation between complement activation product levels of the MASP-1/C1-INH complex (p=0.0011) and C4d (p&lt;0.0001) and COVID-19 severity. Despite this, genetic variations in MBL2 are not associated with susceptibility to SARS-CoV-2 infection or disease outcomes such as mortality and the development of Long COVID.ConclusionIn conclusion, activation of the MBL-LP only plays a minor role in COVID-19 pathogenesis, since no clinically meaningful, consistent associations with disease outcomes were noted

The role of the particle aspect ratio in the discharge of a narrow silo

The time evolution of silo discharge is investigated for different granular materials made of spherical or elongated grains in laboratory experiments and with discrete element model (DEM) calculations. For spherical grains, we confirm the widely known typical behavior with constant discharge rate (except for initial and final transients). For elongated particles with aspect ratios between 2 < L/d < 6.1, we find a peculiar flow rate increase for larger orifices before the end of the discharge process. While the flow field is practically homogeneous for spherical grains, it has strong gradients for elongated particles with a fast-flowing region in the middle of the silo surrounded by a stagnant zone. For large enough orifice sizes, the flow rate increase is connected with a suppression of the stagnant zone, resulting in an increase in both the packing fraction and flow velocity near the silo outlet within a certain parameter range

Flow in an hourglass: particle friction and stiffness matter

Granular flow out of a silo is studied experimentally and numerically. The time evolution of the discharge rate as well as the normal force (apparent weight) at the bottom of the container is monitored. We show that particle stiffness has a strong effect on the qualitative features of silo discharge. For deformable grains with a Young modulus of about Ym ¿ 40 kPa in a silo with basal pressure of the order of 4 kPa, lowering the friction coefficient leads to a gradual change in the discharge curve: the flow rate becomes filling height dependent, it decreases during the discharge process. For hard grains with a Young modulus of about Ym ¿ 500 MPa the flow rate is much less sensitive to the value of the friction coefficient. Using DEM data combined with a coarse-graining methodology allows us to compute all the relevant macroscopic fields, namely, linear momentum, density and stress tensors. The observed difference in the discharge in the low friction limit is connected to a strong difference in the pressure field: while for hard grains Janssen-screening is effective, leading to high vertical stress near the silo wall and small pressure above the orifice region, for deformable grains the pressure above the orifice is larger and gradually decreases during the discharge process. We have analyzed the momentum balance in the region of the orifice (near the location of the outlet) for the case of soft particles with low friction coefficient, and proposed a phenomenological..