Simulated Effect of Carbon Black on High Speed Laser Transmission Welding of Polypropylene With Low Line Energy

Laser welding is an important manufacturing tool for a wide variety of polymer products including consumer goods, automotive components and medical devices. The laser process parameters and polymer properties have a significant impact on weld quality. Due to higher heat density generated by the laser transmission welding (LTW) technique, defining a set of suitable parameters for LTW of thermoplastics and composites can be challenging. In this work the effect of carbon black along other control parameters has been investigated for high speed welding using a laser source of 980 nm wavelength with low line energy. In this work, the finite element method (FEM)-based software COMSOL Multiphysics is used to create a 3D transient thermal model for LTW of isotactic polypropylene (iPP) and its composites with carbon black (CB) of concentrations ranging from 0.5 wt% to 1.5 wt%. The design of experiments based on Box-Behnken design (BBD) is used to organize the simulation experiments and mathematical models are developed based on multiple curvilinear regression analysis on the simulation findings. Independent control variables include the laser power, welding speed, beam diameter, and carbon black content in the absorbent polymer. The maximum weld temperature, weld width, and weld depth within the transmissive and absorptive layers are considered as dependent response variables. Furthermore, sensitivity analysis is carried out to investigate the impact of carbon black along with other independent variables on the responses. The welding feasibility check was performed on the basis of melt and degradation temperature of the materials, and weld depths of transmissive and absorptive layers. It has been observed that the composites containing 0.5 wt% and 1 wt% of CB can be welded successfully with neat iPP. However, due to a degradation temperature problem, composites having a larger proportion of CB (>1 wt%) appear to be more difficult to weld

Planning for climate change impacts on geoheritage interests in protected and conserved areas

Climate change presents challenges for the management of geoheritage at all scales from individual geosites to whole landscapes, and affecting all areas of the planet. Direct impacts will arise principally through the effects of climate changes on geomorphological processes and vegetation cover, while indirect impacts will result from hard engineering interventions to mitigate risks from natural hazards. We present an indicative framework that sets out key steps to help geoconservation practitioners and managers of all protected and conserved areas (PCAs) with geoheritage interests to assess and manage the impacts of climate change on geoheritage. Strategies for mitigation and adaptation to assist contingency planning and implementation should be supported by site condition monitoring and as far as possible work with nature, but will require to be adaptive in the face of many uncertainties. Our approach is based on assessment of the risk of degradation of geosites and their features and processes arising from the likelihood of climate change affecting them and the predicted severity of impacts. The risk of degradation of a site, feature or process will depend on (i) its geographic location and proximity to geomorphological systems that are likely to respond dynamically to climate changes; (ii) the magnitude, rate and duration of these changes; and (iii) intrinsic factors that include the geological and physical characteristics of the site and its features and processes. Management options range from non-intervention to planned interventions informed by the risk of degradation assessment. However, documentation for posterity may be the only practical option for geoheritage interests close to existential thresholds, such as small mountain glaciers, and sites at risk from sea-level rise and coastal or river erosion. Adaptation strategies for geoheritage in protected and conserved areas should, as far as practicable, align with those for biodiversity and aim to deliver multiple co-benefits for nature and people, although economic, social and political constraints may hinder implementation where wider stakeholder interests are involved. Managers of PCAs will need substantial input from geoconservation experts to carry out the assessments recommended and determine the action required.Publisher PDFPeer reviewe

Benthic habitats of Buck Island Reef National Monument

NOAA’s Center for Coastal Monitoring and Assessment’s Biogeography Branch has mapped and characterized large portions of the coral reef ecosystems inside the U.S. coastal and territorial waters, including the U.S. Caribbean. The complementary protocols used in these efforts have enabled scientists and managers to quantitatively compare different marine ecosystems in tropical U.S. waters. The Biogeography Branch used these same general protocols to generate three seamless habitat maps of the Bank/Shelf (i.e., from 0 ≤50 meters) and the Bank/Shelf Escarpment (i.e., from 50 ≤1,000 meters and from 1,000 ≤ 1,830 meters) inside Buck Island Reef National Monument (BIRNM). While this mapping effort marks the fourth time that the shallow-water habitats of BIRNM have been mapped, it is the first time habitats deeper than 30 meters (m) have been characterized. Consequently, this habitat map provides information on the distribution of mesophotic and deep-water coral reef ecosystems and serves as a spatial baseline for monitoring change in the Monument. A benthic habitat map was developed for approximately 74.3 square kilometers or 98% of the BIRNM using a combination of semi-automated and manual classification methods. The remaining 2% was not mapped due to lack of imagery in the western part of the Monument at depths ranging from 1,000 to 1,400 meters. Habitats were interpreted from orthophotographs, LiDAR (Light Detection and Ranging) imagery and four different types of MBES (Multibeam Echosounder) imagery. Three minimum mapping units (MMUs) (100, 1,000 and 5,000 square meters) were used because of the wide range of depths present in the Monument. The majority of the area that was characterized was deeper than 30 m on the Bank/Shelf Escarpment. This escarpment area was dominated by uncolonized sand which transitioned to mud as depth increased. Bedrock was exposed in some areas of the escarpment, where steep slopes prevented sediment deposition. Mesophotic corals were seen in the underwater video, but were too sparsely distributed to be reliably mapped from the source imagery. Habitats on the Bank/Shelf were much more variable than those seen on the Bank/Shelf Escarpment. The majority of this shelf area was comprised of coral reef and hardbottom habitat dominated by various forms of turf, fleshy, coralline or filamentous algae. Even though algae was the dominant biological cover type, nearly a quarter (24.3%) of the Monument’s Bank/Shelf benthos hosted a cover of 10%-<50% live coral. In total, 198 unique combinations of habitat classes describing the geography, geology and biology of the sea-floor were identified from the three types of imagery listed above. No thematic accuracy assessment was conducted for areas deeper than about 50 meters, most of which was located in the Bank/Shelf Escarpment. The thematic accuracy of classes in waters shallower than approximately 50 meters ranged from 81.4% to 94.4%. These thematic accuracies are similar to those reported for other NOAA benthic habitat mapping efforts in St. John (>80%), the Main Eight Hawaiian Islands (>84.0%) and the Republic of Palau (>80.0%). These digital maps products can be used with confidence by scientists and resource managers for a multitude of different applications, including structuring monitoring programs, supporting management decisions, and establishing and managing marine conservation areas. The final deliverables for this project, including the benthic habitat maps, source imagery and in situ field data, are available to the public on a NOAA Biogeography Branch website (http://ccma.nos.noaa.gov/ecosystems/coralreef/stcroix.aspx) and through an interactive, web-based map application (http://ccma.nos.noaa.gov/explorer/biomapper/biomapper.html?id=BUIS). This report documents the process and methods used to create the shallow to deep-water benthic habitat maps for BIRNM. Chapter 1 provides a short introduction to BIRNM, including its history, marine life and ongoing research activities. Chapter 2 describes the benthic habitat classification scheme used to partition the different habitats into ecologically relevant groups. Chapter 3 explains the steps required to create a benthic habitat map using a combination of semi-automated and visual classification techniques. Chapter 4 details the steps used in the accuracy assessment and reports on the thematic accuracy of the final shallow-water map. Chapter 5 summarizes the type and abundance of each habitat class found inside BIRNM, how these habitats compare to past habitat maps and outlines how these new habitat maps may be used to inform future management activities

Canakinumab reverses overexpression of inflammatory response genes in tumour necrosis factor receptor-associated periodic syndrome

OBJECTIVE: To explore whether gene expression profiling can identify a molecular mechanism for the clinical benefit of canakinumab treatment in patents with tumour necrosis factor receptor-associated periodic syndrome (TRAPS). METHODS: Blood samples were collected from 20 patients with active TRAPS who received canakinumab 150 mg every 4 weeks for 4 months in an open-label proof-of-concept phase II study, and from 20 aged-matched healthy volunteers. Gene expression levels were evaluated in whole blood samples by microarray analysis for arrays passing quality control checks. RESULTS: Patients with TRAPS exhibited a gene expression signature in blood that differed from that in healthy volunteers. Upon treatment with canakinumab, many genes relevant to disease pathogenesis moved towards levels seen in the healthy volunteers. Canakinumab downregulated the TRAPS-causing gene (TNF super family receptor 1A (TNFRSF1A)), the drug-target gene (interleukin (IL)-1B) and other inflammation-related genes (eg, MAPK14). In addition, several inflammation-related pathways were evident among the differentially expressed genes. Canakinumab treatment reduced neutrophil counts, but the observed expression differences remained after correction for this. CONCLUSIONS: These gene expression data support a model in which canakinumab produces clinical benefit in TRAPS by increasing neutrophil apoptosis and reducing pro-inflammatory signals resulting from the inhibition of IL-1β. Notably, treatment normalised the overexpression of TNFRSF1A, suggesting that canakinumab has a direct impact on the main pathogenic mechanism in TRAPS. TRIAL REGISTRATION NUMBER: NCT01242813