Ergebnisse nach Osteosynthese distaler Radiusfrakturen mit dem Fixateur externe

Es wurden 32 distale Radius-Trümmerfrakturen nach Versorgung mit einem Fixateur externe im Zeitraum von 1985-1998 nachuntersucht. Die Daten wurden aus dem Patientengut der Staatlich Orthopädischen Klinik Harlaching erhoben. Die Klassifikation der Frakturen erfolgte nach den Kriterien der AO, der Klassifikation nach Frykman und den Instabilitätskriterien nach Poigenfürst. Die gewonnen Daten wurden unter anderem nach der in der Literatur häufig verwendeten Lidström-Klassifikation für distale Radiusfrakturen aufgeschlüsselt, um so auch funktionelle, röntgenologisch-anatomisch und kosmetische Aussagen zu bekommen. Das funktionelle Ergebnis war in 87,5 % der Fälle gut bis sehr gut, obwohl 30 von 32 (93,8%) Patienten komplexe C-Frakturen in der Einteilung nach AO erlitten, bzw. Frykman Frakturen Typ VII und VIII. Anatomisch-röntgenologisch korrelierte das Ergebnis überraschend gut. Auch hier hatten die Patienten in 87,5% sehr gute oder gute Ergebnisse. Diese Ergebnisse sind durchaus zufrieden stellend. Es gab nur eine Komplikation durch einen Morbus Sudeck (3,1%). Dies entspricht vergleichbarer Literatur. Insgesamt bestätigte sich unsere Ansicht, dass die von Poigenfürst definierten Instabilitätskriterien einen guten Hinweis auf die Art der Versorgung geben. Diese wurden von uns ergänzt. Folgende Risikokriterien wurden herangezogen: 1. Ulnare Seitenbandinstabilität, 2. Instabilität des distalen Radioulnargelenkes, 3. Fragmentdislokation nach dorsal größer 15°, 4. Trümmerfrakturen mit Destruktion der dorsalen Kortikalis, 5. Osteoporose. Sind drei und mehr Kriterien erfüllt, sollte eine osteosynthetische Versorgung mit dem Fixateur externe angestrebt werden. Diese treten meistens bei C-Frakturen auf

Mastocytosis: a Rare Case of Anaphylaxis in Paediatric Age and Literature Review

The term “mastocytosis” denotes a heterogeneous group of disorders characterised by abnormal growth and accumulation of mast cells (MC) in one or more organ systems. Symptoms result from MC chemical mediator’s release, pathologic infiltration of neoplastic MC in tissues or both. Multiple molecular, genetic and chromosomal defects seem to contribute to an autonomous growth, but somatic c-kit D816V mutation is more frequently encountered, especially in systemic disease. We present a literature review of mastocytosis and a rare case report of an 18 month-old-girl with a bullous dermatosis, respiratory distress and anaphylaxis, as clinical manifestations of mastocytosis. The developments of accepted classification systems and novel useful markers allowed a re-evaluation and updating of the classification of mastocytosis. In paediatric age cutaneous forms of disease prevail and may regress spontaneously. SM is more frequently diagnosed in adults and is a persistent(clonal) disease of bone marrow. The clinical course in these patients is variable.Today diagnostic criteria for each disease variant are reasonably well defined. There are, however, peculiarities, namely in paediatric age, that makes the diagnostic approach difficult. Systemic disease may pose differential diagnostic problems resulting from multiple organ systems involvement. Coversly, the “unexplained” appearance of those symptoms with no skin lesions should raise the suspicion of MC disease. This case is reported in order to stress the clinical severity and difficult diagnostic approach that paediatric mastocytosis may assume

Radiofrequency denervation for treatment of sacroiliac joint pain-comparison of two different ablation techniques

The radiofrequency treatment (RFD) for sacroiliac joint pain (SIP) is well-established, but there is still scarce evidence on its clinical outcome. The classical monopolar RFD is limited by a high recurrence rate. This might be caused by an incomplete denervation of the dorsal rami. The Simplicity III probe was invented to optimise pain fibre recruitment by its multi-electrode design. However, the clinical superiority of this procedure was never proven. The aim of this study was to illustrate the effectiveness of RFD and to compare both denervation techniques. One hundred twenty-one patients were included, and their clinical course was analysed. Fifty-seven patients received conventional treatment with multiple percutaneous monopolar RFDs (monolesion probe group, MoLG) and 64 patients with the Simplicity III probe (multilesion probe group, MuLG). All patients were followed 1, 3, 6 and 12 s after RFD. Clinical outcome scores were analysed (numeric pain rating scale (NPRS), Roland-Morris Disability Questionnaire, Oswestry Disability Index (ODI), Odom's criteria, Short Form 36 score). The MuLG showed a clearly advanced improvement concerning the clinically relevant pain relief (>= 50%) (1 month/3 months /6 months/12 months = 72%, 55%, 36%, 27% vs. 1 month/3 months/6 months/12 months = 39%, 28%, 16%, 11%) as well as an advanced improvement of pain-associated disability and a higher satisfaction rating compared to the MoLG (NPRSMuLG_(preop) = 8,3; NPRSMuLG_(12months) = 5.8; NPRSMoLG_preop = 7,7; NPRSMoLG_12months = 5.8; ODIMuLG_preop = 52; ODIMuLG_12months = 42; ODIMoLG_preop = 52; ODIMoLG_12months = 47; ODOMSMuLG_good/excellent = 54%; ODOMSMoLG_good/excellent = 28%). RFD of the SIP with the Simplicity III probe is effective and delivers a distinct pain reduction even after 1 year of treatment. This technique shows clear advantages compared to the conventional monolesion technique and is a useful treatment for patients with recurrent SIP

Prognostic Implication of Lymphovascular Invasion Detected by Double Immunostaining for D2-40 and MITF1 in Primary Cutaneous Melanoma.

BACKGROUND Lymphovascular invasion (LVI) is associated with adverse outcomes in primary cutaneous melanoma (PCM). Detection of LVI by hematoxylin and eosin staining alone is 0%-6%, but targeting lymphovascular structures increases the detection rate. OBJECTIVE To examine the prognostic significance of LVI detected by immunostaining for D2-40 and microphthalmia-associated transcription factor 1 (MITF1) in PCM. METHODS The authors retrospectively analyzed 120 PCM samples. We compared the LVI detection rates of immunostaining for D2-40 only (22%), double staining for D2-40 and MITF1 (38%), and hematoxylin and eosin, and examined the association of LVI with clinicopathologic variables and clinical outcomes. RESULTS Immunolabeling with both methods significantly increased the LVI detection rate. Double staining for D2-40 and MITF1 as well as D2-40-detected LVI was significantly associated with increased Breslow thickness, number of mitoses, and sentinel lymph node (SLN) metastasis. D2-40-detected LVI was also associated with ulceration. Although the difference was not significant, double staining for D2-40 and MITF1 allowed for easier detection of LVI than D2-40 alone. LIMITATIONS This study was conducted in a tertiary referral institution; therefore, a referral bias cannot be excluded. CONCLUSIONS Immunolabeling increased detection of LVI in PCM. Because LVI is a positive predictive marker for SLN metastasis, the authors propose using anti-D2-40 and anti-MITF1 in the evaluation of LVI in patients with PCM with a certain risk of SLN metastasis