15 research outputs found
Application of Power Flow problem to an open quantum neural hardware
Significant progress in the construction of physical hardware for quantum
computers has necessitated the development of new algorithms or protocols for
the application of real-world problems on quantum computers. One of these
problems is the power flow problem, which helps us understand the generation,
distribution, and consumption of electricity in a system. In this study, the
solution of a balanced 4-bus power system supported by the Newton-Raphson
method is investigated using a newly developed dissipative quantum neural
network hardware. This study presents the findings on how the proposed quantum
network can be applied to the relevant problem and how the solution performance
varies depending on the network parameters.Comment: 5 Figures, 6 Page
CFTR mutations unidentified in CFTR2 database and their phenotypic characteristics: Data from cystic fibrosis registry of Turkey
Cystic fibrosis in Turkey: First data from the national registry.
Background Cystic fibrosis (CF) care has been implemented in Turkey for a long time; however, there had been no patient registry. For this purpose, the Turkish National CF Registry was established. We present the first results of registry using data collected in 2017. Methods The data were collected using a data-entry software system, which was accessed from the internet. Demographic and annually recorded data consisted of 15 and 79 variables, respectively. Results There were 1170 patients registered from 23 centers; the estimated coverage rate was 30%. The median age at diagnosis was 1.7 years (median current age: 7.3 years); 51 (4.6%) patients were aged over 18 years. Among 293 patients who were under 3 years of age, 240 patients (81.9%) were diagnosed through newborn screening. Meconium ileus was detected in 65 (5.5%) patients. Genotyping was performed in 978 (87.4%) patients and 246 (25.2%) patients' mutations were unidentified. The most common mutation was deltaF508 with an allelic frequency of 28%, followed by N1303K (4.9%). The median FEV1% predicted was 86. Chronic colonization with Pseudomonas aeruginosa was seen in 245 patients. The most common complication was pseudo-Bartter syndrome in 120 patients. The median age of death was 13.5 years in a total of 15 patients. Conclusions Low coverage rate, lack of genotyping, unidentified mutations, and missing data of lung functions are some of our greatest challenges. Including data of all centers and reducing missing data will provide more accurate data and help to improve the CF care in Turkey in the future
Clinical features and accompanying findings of Pseudo-Bartter Syndrome in cystic fibrosis
Background Pseudo-Bartter syndrome (PBS) is a rare complication of cystic fibrosis (CF) and there are limited data in the literature about it. We aimed to compare clinical features and accompanying findings of patients with PBS in a large patient population