Tracking Intrinsic Non-Hermitian Skin Effect in Lossy Lattices

Non-Hermitian skin effect (NHSE), characterized by a majority of eigenstates localized at open boundaries, is one of the most iconic phenomena in non-Hermitian lattices. Despite notable experimental studies implemented, most of them witness only certain signs of the NHSE rather than the intrinsic exponential localization inherent in eigenstates, owing to the ubiquitous and inevitable background loss. Even worse, the experimental observation of the NHSE would be completely obscured in highly lossy cases. Here, we theoretically propose a dual test approach to eliminate the destructive loss effect and track the intrinsic NHSE that is essentially irrelevant to background loss. Experimentally, the effectiveness of this approach is precisely validated by one- and two-dimensional non-Hermitian acoustic lattices. Our study sheds new light on the previously untapped intrinsic aspect of the NHSE, which is of particular significance in non-Hermitian topological physics

DataSheet1_The serum acylcarnitines profile in epileptic children treated with valproic acid and the protective roles of peroxisome proliferator-activated receptor a activation in valproic acid-induced liver injury.pdf

Valproic acid (VPA) is widely used as a major drug in the treatment of epilepsy. Despite the undisputed pharmacological importance and effectiveness of VPA, its potential hepatotoxicity is still a major concern. Being a simple fatty acid, the hepatotoxicity induced by VPA has long been considered to be due primarily to its interference with fatty acid β-oxidation (β-FAO). The aim of this study was to investigate the biomarkers for VPA-induced abnormal liver function in epileptic children and to determine potential mechanisms of its liver injury. Targeted metabolomics analysis of acylcarnitines (ACs) was performed in children’s serum. Metabolomic analysis revealed that VPA -induced abnormal liver function resulted in the accumulation of serum long-chain acylcarnitines (LCACs), and the reduced expression of β-FAO relevant genes (Carnitine palmitoyltrans-ferase (CPT)1, CPT2 and Long-chain acyl-CoA dehydrogenase (LCAD)), indicating the disruption of β-FAO. As direct peroxisome proliferator-activated receptor a (PPARα)- regulated genes, CPT1A, CPT2 and LCAD were up-regulated after treatment with PPARα agonist, fenofibrate (Feno), indicating the improvement of β-FAO. Feno significantly ameliorated the accumulation of various lipids in the plasma of VPA-induced hepatotoxic mice by activating PPARα, significantly reduced the plasma ACs concentration, and attenuated VPA-induced hepatic steatosis. Enhanced oxidative stress and induced by VPA exposure were significantly recovered using Feno treatment. In conclusion, this study indicates VPA-induced β-FAO disruption might lead to liver injury, and a significant Feno protective effect against VPA -induced hepatotoxicity through reversing fatty acid metabolism.</p

Influence of Environmental Factors on the Site Selection and Layout of Ancient Military Towns (Zhejiang Region)

There are many subjective inferences regarding environment-related studies in modern studies of ancient military defense heritage, and the objective quantitative analysis of citadel site selection and layout has become the key to interpreting the environmental adaptability of citadels under defense strategies. Based on this, it has been proposed in this research that the site selection of ancient military citadels in a specific region (Zhejiang) has environmental adaptability characteristics. Firstly, an elevated hydrological overlay model was established by predicting and graphically verifying the ancient hydrological thresholds through geospatial analysis strategies. Secondly, the hydrological and topographical indicators of the regional environment where the military citadel is located were digitally extracted. Finally, correlation and weight influence calculations were performed for different environmental data. The environmental adaptability characteristics of the site layout of the Ming dynasty-era Zhejiang coastal defense military citadel, based on military defense needs, were obtained. In this way, we promote digital technology for the excavation, conservation and sustainable use of heritage resources

Genome sequencing of the high oil crop sesame provides insight into oil biosynthesis

Background: Sesame, Sesamum indicum L., is considered the queen of oilseeds for its high oil content and quality, and is grown widely in tropical and subtropical areas as an important source of oil and protein. However, the molecular biology of sesame is largely unexplored.Results: Here, we report a high-quality genome sequence of sesame assembled de novo with a contig N50 of 52.2 kb and a scaffold N50 of 2.1 Mb, containing an estimated 27,148 genes. The results reveal novel, independent whole genome duplication and the absence of the Toll/interleukin-1 receptor domain in resistance genes. Candidate genes and oil biosynthetic pathways contributing to high oil content were discovered by comparative genomic and transcriptomic analyses. These revealed the expansion of type 1 lipid transfer genes by tandem duplication, the contraction of lipid degradation genes, and the differential expression of essential genes in the triacylglycerol biosynthesis pathway, particularly in the early stage of seed development. Resequencing data in 29 sesame accessions from 12 countries suggested that the high genetic diversity of lipid-related genes might be associated with the wide variation in oil content. Additionally, the results shed light on the pivotal stage of seed development, oil accumulation and potential key genes for sesamin production, an important pharmacological constituent of sesame.Conclusions: As an important species from the order Lamiales and a high oil crop, the sesame genome will facilitate future research on the evolution of eudicots, as well as the study of lipid biosynthesis and potential genetic improvement of sesame