Study of the features of masticatory efficiency in patients with acute cerebrovascular disorder by hemitype

The attention of dental researchers is constantly focused on assessing the quality of treatment for various pathologies of the dentоalveolar system, determining disorders of occlusal correlations, treatment, and prevention of diseases of the temporomandibular joint and periodontal tissue pathology. Numerous studies on the above aspects contain information on the characteristics of masticatory efficiency as one of the most vivid markers of orthopedic treatment, as it allows dentists to determine the quality of actual masticatory performance.The issues of functional diagnostics at the stages of rehabilitation of patients with partial defects of the dentition remain relevant, and therefore, the indicators of masticatory efficiency in prosthetics with removable dentures will be one of the most important criteria for adaptation to them. The situation exacerbates when such patients suffer from somatic pathologies of a neurological nature, in particular, acute cerebrovascular disorder.The aim of the research was to study the features of masticatory function in patients with a complicated course of acute cerebrovascular disorder with the neurological deficit by hemitypeThe study involved 25 people with a complicated course of acute cerebrovascular disorder with the neurological deficit by hemitype and 20 people from the control group, aged from 40 to 65 years, for whom partial removable laminar dentures with acrylic base and retaining bent metal clasps were manufactured according to clinical indications. All patients gave their free and informed consent to participate in the study.The masticatory efficiency was determined using the author's method based on the principle of graphical analysis of fragments of the agar-agar masticatory sample with subsequent programmed calculation and computer processing of numerical data.The evaluation indicators were as follows: the total number of fragments of the chewing sample and the number of fragments with a fraction of 500-1000 pixel2.Statistical analysis of the results was conducted using the Statistica 10.0 software package for Windows, and it embraced the following:1. Assessing the distribution of values and their correspondence to the normal one in the population.2. Comparison of the results obtained before applying a removable dental prosthesis and 30 days after its application.3. Intergroup comparison of the results.Thus, we observed an increase in the chewing sample parameters in the period from the beginning of orthopedic treatment until the 30th day of observation after applying a partial removable laminar denture. Despite the general trend, in the group of patients with ACVD, the masticatory efficiency was lower than that of the control group, which is confirmed by the difference between the total number of fragments (<17.22) and the number of fragments with a caliber of 500 to 1000 pixel2 (<4.41). In our opinion, this is due to the peculiarities of adaptation processes in patients with ACVD, who present with a much longer period than patients without a somatic pathology.The study revealed that the masticatory efficiency, restored by prosthetics with removable laminar dentures in the group of patients with a complicated course of ACVD by hemitype, one month after treatment is at the level of 88.68 (total number of fragments of the chewing sample) and 17.04 (number of fragments with a caliber of 500-1000 pixel2), which is a relatively worse indicator as compared to the control group. Thus, the total period of orthopedic rehabilitation for patients with ACVD is longer

Long-Term Survival of a Patient with Giant Cell Glioblastoma: Case Report and Review of the Literature

Glioblastoma multiforme (GBM) is the most common glial tumor of the central nervous system. Overall survival is less than a year in most of the cases in spite of multimodal treatment approaches. A 45-year-old female with histologically confirmed giant cell GBM was treated at our institution. Subtotal excision of the lesion situated in the right precentral area was performed during the initial stay in August 2005. The patient improved after the procedure with no hypertension and additional neurological deficit. Radiotherapy plus concomitant and adjuvant temozolomide was performed. The patient was symptom-free for 35 months after initial surgery. From July 2008 the patient developed partial motor seizures in the left side of the body and progressive hemiparesis. Local tumor progression was demonstrated on the neuroimaging studies. In December 2008, a second operative intervention was performed with subtotal excision of the tumor. Forty-five months after the initial diagnosis the patient is still alive with moderate neurological deficit. Microarray analysis of the tumor found the following numeric chromosomal aberrations: monosomy 8, 10, 13, 22, and trisomy 21, as well as amplifications in 4q34.1, 4q28.2, 6q16.3, 7q36.1, 7p21.3, and deletions in 1q42.12, 1q32.2, 1q25.2, 1p33, 2q37.2, 18q22.3, 19p13.2, Xq28, and Xq27.3. GBMs seem to be a heterogeneous group of glial tumors with different clinical course and therapeutic response. Microarray analysis is a useful method to establish a number of possible molecular predictors

The myogymnastics complex as an element of rehabilitation in the process of adaptation to orthopedic appliances in patients after stroke

Introduction. Stroke has become the second leading cause of long-term disability and cognitive impairment. The disease can cause debilitating neurological disorders that lead to motor, sensory and cognitive deficits and impaired psychosocial functioning. Many researchers have established an association between dental status, infections, and systemic diseases such as acute cerebrovascular disorder.The aim of the research was to determine the impact of dental health on the quality of life in patients with cerebral circulatory disorders complicated with neurological deficits by hemitype before and 30 days after orthopedic treatment by questionnaire survey.Materials and methods. The study involved 25 people with the course of ACVD complicated with neurological deficiency by hemitype, aged from 40 to 65 years, who underwent prosthetics with partial removable laminar dentures with acrylic base and retaining bent, metal clasps according to clinical indications. The first group, where the process of adaptation to the orthopedic appliance was normal, consisted of 13 people, including 7 women and 6 men. In the second group, the adaptation process took place using the proposed rehabilitation complex, and it comprised 12 patients, including 7 women and 5 men.The changes that occurred 30 days after applying a partial removable laminar denture were as follows:The value of the indicator of restricted masticatory function in subjects of the first study group was worse by 1.375 points as compared to the second group. The value of the indicator of physical pain in the process of adaptation to the orthopedic appliance was noteworthy, since it decreased significantly in the second group and amounted to 14.404 points, which was by 1.335 points higher than in patients of the first group.The level of psychological discomfort in patients of the first group was 32.412 points, which was 1.183 points different from that of patients in the second group, in favor of the latter. At the same time, a comparison of the level of psychological inferiority showed that this indicator was higher in the first group than in the second study group by 0.988 points, i.e., the dynamics of changes in this indicator was better in the second one.Comparison of the level of social inferiority showed that in the first study group it was higher by 2.106 points than in the third group. Comparison of the level of disability showed a difference of this indicator by 1.226 points in favor of patients of the second groupThe above data suggest a general trend of improving the basic health indicators of patients in the process of orthopedic rehabilitation. At the same time, there was a clear difference between the results of the questionnaire survey between patients of the first and second groups, and these indicators were better in the latter.Conclusions. The effectiveness of the proposed rehabilitation complex for patients with cerebral circulatory disorders complicated with neurological deficiency by hemitype after prosthetics with partial removable laminar appliances was confirmed by a decrease in numerical data from the questionnaire survey by 15%, indicating an improvement in quality of life in this category of patients

Mitochondrial DNA Suggests a Western Eurasian origin for Ancient (Proto-) Bulgarians

Ancient (proto-) Bulgarians have long been thought to as a Turkic population. However, evidence found in the past three decades show that this is not the case. Until now, this evidence does not include ancient mitochondrial DNA (mtDNA) analysis. In order to fill this void, we have collected human remains from the VIII-X century AD located in three necropolises in Bulgaria: Nojarevo (Silistra region) and Monastery of Mostich (Shumen region), both in Northeast Bulgaria and Tuhovishte (Satovcha region) in Southwest Bulgaria. The phylogenetic analysis of 13 ancient DNA samples (extracted from teeth) identified 12 independent haplotypes, which we further classified into mtDNA haplogroups found in present-day European and Western Eurasian populations. Our results suggest a Western Eurasian matrilineal origin for proto-Bulgarians as well as a genetic similarity between proto- and modern Bulgarians. Our future work will provide additional data which will further clarify proto-Bulgarian origins; thereby adding new clues to current understanding of European genetic evolution

Artificial intelligence – the new suggestion for biomedicine, dentistry and healthcare

The development of technologies based on Artificial Intelligence (AI) and their application in medicine is growing rapidly. Innovations in digital technology, telemedicine, 5G technology and artificial intelligence (AI) create new opportunities for the development of the healthcare system. The aim of the present study is to explore the possibilities for the application of artificial intelligence in biomedicine, dentistry, healthcare and healthcare. In recent years there have been many major innovations, including the introduction of many new information and communication technologies. Digital innovations, including the further inclusion of telemedicine, the development of 5th generation wireless networks (5G) and artificial intelligence (AI) approaches, create an exceptional ecosystem for new health opportunities. The digital health sector creates a favorable environment for the provision of health services at a very high level

Determination of fractal dimension of the functional masticatory test patterns

Valid diagnostic assessment of the state of dentoalveolar system and its masticatory function, in particular, is considered to be an important scientific task of modern prosthodontics. Plenty of the developed ways are based on the use of up-to-date information technology, especially on computer analysis of graphic data. The development of the enhanced methods for the evaluation of masticatory efficiency in patients with both full and partial adentia urged the search of its clear and informative indicators. According to the authors, digital image fractal dimension index can meet these needs. Since most of the available masticatory function assessment methods involve the obtaining large ammount of fragments different in their quantity, size and shape. The photography of the multiplicity of these 'spasmodically' located objects allows the processing of the received image with the help of graphic editor and converting it into numeric data. Thus, the aim of the research was to study the fractal dimension of the masticatory test images, taking into account the peculiarities of the patients'denture defects. Computer software for digital image processing ImageJ 1.50b was used in the research, since it provides the option of computer calculation of the fractal dimension index. The comparison of the masticatory tests of 30 persons with intact teeth (control group) and 33 persons with denture defects has revealed statistically significant deviation in their fractal dimension index. The reduction of the range of conventional statistical norm (1.49-1.66) to the values fluctuating from 1.47 to 1.51. was observed. Therefore, the decrease of the mean value of the fractal dimension from 1.56 (St.Err.- 0.02) to 1.50 indicates the reduction of chopping function in the given masticatory test patterns. As a result, the suggested method will allow the use of fractal dimension index as an integral indicator of masticatory efficiency level

Y-Chromosome Diversity in Modern Bulgarians: New Clues about Their Ancestry

To better define the structure and origin of the Bulgarian paternal gene pool, we have examined the Y-chromosome variation in 808 Bulgarian males. The analysis was performed by high-resolution genotyping of biallelic markers and by analyzing the STR variation within the most informative haplogroups. We found that the Y-chromosome gene pool in modern Bulgarians is primarily represented by Western Eurasian haplogroups with , 40% belonging to haplogroups E-V13 and I-M423, and 20% to R-M17. Haplogroups common in the Middle East (J and G) and in South Western Asia (R-L23*) occur at frequencies of 19% and 5%, respectively. Haplogroups C, N and Q, distinctive for Altaic and Central Asian Turkic-speaking populations, occur at the negligible frequency of only 1.5%. Principal Component analyses group Bulgarians with European populations, apart from Central Asian Turkic-speaking groups and South Western Asia populations. Within the country, the genetic variation is structured in Western, Central and Eastern Bulgaria indicating that the Balkan Mountains have been permeable to human movements. The lineage analysis provided the following interesting results: (i) R-L23* is present in Eastern Bulgaria since the post glacial period; (ii) haplogroup E-V13 has a Mesolithic age in Bulgaria from where it expanded after the arrival of farming; (iii) haplogroup J-M241 probably reflects the Neolithic westward expansion of farmers from the earliest sites along the Black Sea. On the whole, in light of the most recent historical studies, which indicate a substantial proto-Bulgarian input to the contemporary Bulgarian people, our data suggest that a common paternal ancestry between the proto-Bulgarians and the Altaic and Central Asian Turkic-speaking populations either did not exist or was negligible

Ancient human mitochondrial genomes from Bronze Age Bulgaria: new insights into the genetic history of Thracians

Abstract One of the best documented Indo-European civilizations that inhabited Bulgaria is the Thracians, who lasted for more than five millennia and whose origin and relationships with other past and present-day populations are debated among researchers. Here we report 25 new complete mitochondrial genomes of ancient individuals coming from three necropolises located in different regions of Bulgaria – Shekerdja mogila, Gabrova mogila and Bereketska mogila – dated to II-III millennium BC. The identified mtDNA haplogroup composition reflects the mitochondrial variability of Western Eurasia. In particular, within the ancient Eurasian genetic landscape, Thracians locate in an intermediate position between Early Neolithic farmers and Late Neolithic-Bronze Age steppe pastoralists, supporting the scenario that the Balkan region has been a link between Eastern Europe and the Mediterranean since the prehistoric time. Spatial Principal Component Analysis (sPCA) performed on Thracian and modern mtDNA sequences, confirms the pattern highlighted on ancient populations, overall indicating that the maternal gene pool of Thracians reflects their central geographical position at the gateway of Europe

Human β-Defensin 2 Mutations Are Associated With Asthma and Atopy in Children and Its Application Prevents Atopic Asthma in a Mouse Model

Asthma and allergies are complex, chronic inflammatory diseases in which genetic and environmental factors are crucial. Protection against asthma and allergy development in the context of farming environment is established by early animal contact, unpasteurized milk consumption and gut microbiota maturation. The human β-defensin 2 (hBD-2) is a host defense peptide present almost exclusively in epithelial tissues, with pronounced immunomodulatory properties, which has recently been shown to ameliorate asthma and IBD in animal models. We hypothesized that adequate hBD-2 secretion plays a role in the protection against asthma and allergy development and that genetic variations in the complex gene locus coding for hBD-2 may be a risk factor for developing these diseases, if as a consequence, hBD-2 is insufficiently produced. We used MALDI-TOF MS genotyping, sequencing and a RFLP assay to study the genetic variation including mutations, polymorphisms and copy number variations in the locus harboring both genes coding for hBD-2 (DEFB4A and DEFB4B). We administered hBD-2 orally in a mouse model of house dust mite (HDM)-asthma before allergy challenge to explore its prophylactic potential, thereby mimicking a protective farm effect. Despite the high complexity of the region harboring DEFB4A and DEFB4B we identified numerous genetic variants to be associated with asthma and allergy in the GABRIELA Ulm population of 1,238 children living in rural areas, including rare mutations, polymorphisms and a lack of the DEFB4A. Furthermore, we found that prophylactic oral administration of hBD-2 significantly curbed lung resistance and pulmonary inflammation in our HDM mouse model. These data indicate that inadequate genetic capacity for hBD-2 is associated with increased asthma and allergy risk while adequate and early hBD-2 administration (in a mouse model) prevents atopic asthma. This suggests that hBD-2 could be involved in the protective farm effect and may be an excellent candidate to confer protection against asthma development

Щодо питання різних методів полімеризації базисних пластмас

Наведена порівняльна характеристика компресійного і ливарного пресування. Ураховуючи всі недолі- ки та переваги обох методів пресування, доведені вагомі переваги ливарного пресування при виготов- ленні знімних конструкцій; Приведена сравнительная характеристика компрессионного и литьевого прессования. Учитывая все недостатки и преимущества обоих методов прессования, доказаны весомые преимущества литьевого прессования при изготовлении съёмных конструкций; Тhe article describes the comparative characteristics of compressive and casting pressing. Considering disadvantages and advantages of both methods, it was proved some advantages of the usage of the casting pressing during construction of removable constructions