9 research outputs found
ALMA Observations of the Submillimeter Dense Molecular Gas Tracers in the Luminous Type-1 Active Nucleus of NGC 7469
We present ALMA Cycle 1 observations of the central kpc region of the
luminous type-1 Seyfert galaxy NGC 7469 with unprecedented high resolution
(0.5 0.4 = 165 pc 132 pc) at submillimeter wavelengths.
Utilizing the wide-bandwidth of ALMA, we simultaneously obtained HCN(4-3),
HCO(4-3), CS(7-6), and partially CO(3-2) line maps, as well as the 860
m continuum. The region consists of the central 1 component and
the surrounding starburst ring with a radius of 1.5-2.5. Several
structures connect these components. Except for CO(3-2), these dense gas
tracers are significantly concentrated towards the central 1,
suggesting their suitability to probe the nuclear regions of galaxies. Their
spatial distribution resembles well those of centimeter and mid-infrared
continuum emissions, but it is anti-correlated with the optical one, indicating
the existence of dust obscured star formation. The integrated intensity ratios
of HCN(4-3)/HCO(4-3) and HCN(4-3)/CS(7-6) are higher at the AGN position
than at the starburst ring, which is consistent to our previous findings
(submm-HCN enhancement). However, the HCN(4-3)/HCO(4-3) ratio at the AGN
position of NGC 7469 (1.110.06) is almost half of the corresponding value
of the low-luminosity type-1 Seyfert galaxy NGC 1097 (2.00.2), despite the
more than two orders of magnitude higher X-ray luminosity of NGC 7469. But the
ratio is comparable to that of the close vicinity of the AGN of NGC 1068
( 1.5). Based on these results, we speculate that some other heating
mechanisms than X-ray (e.g., mechanical heating due to AGN jet) can contribute
significantly for shaping the chemical composition in NGC 1097.Comment: Fixed typos in the title. 15 pages, 8 figures, 4 tables: accepted for
publication in ApJ. Comments welcom
Comparison of clinical outcomes between luminal invasive ductal carcinoma and luminal invasive lobular carcinoma
Protective Effect of Ferulic Acid against Hydrogen Peroxide Induced Apoptosis in PC12 Cells
Ferulic Acid (FA) is a highly abundant phenolic phytochemical which is present in plant tissues. FA has biological effects on physiological and pathological processes due to its anti-apoptotic and anti-oxidative properties, however, the detailed mechanism(s) of function is poorly understood. We have identified FA as a molecule that inhibits apoptosis induced by hydrogen peroxide (H2O2) or actinomycin D (ActD) in rat pheochromocytoma, PC12 cell. We also found that FA reduces H2O2-induced reactive oxygen species (ROS) production in PC12 cell, thereby acting as an anti-oxidant. Then, we analyzed FA-mediated signaling responses in rat pheochromocytoma, PC12 cells using antibody arrays for phosphokinase and apoptosis related proteins. This FA signaling pathway in PC12 cells includes inactivation of pro-apoptotic proteins, SMAC/Diablo and Bad. In addition, FA attenuates the cell injury by H2O2 through the inhibition of phosphorylation of the extracellular signal-regulated kinase (ERK). Importantly, we find that FA restores expression levels of brain-derived neurotrophic factor (BDNF), a key neuroprotective effector, in H2O2-treated PC12 cells. As a possible mechanism, FA increases BDNF by regulating microRNA-10b expression following H2O2 stimulation. Taken together, FA has broad biological effects as a neuroprotective modulator to regulate the expression of phosphokinases, apoptosis-related proteins and microRNAs against oxidative stress in PC12 cells
Assessment of muscle involvement in patients with Duchenne muscular dystrophy via segmental multifrequency bioelectrical analysis
Additional file 1: of Comparison of clinical outcomes between luminal invasive ductal carcinoma and luminal invasive lobular carcinoma
Dataset supporting the conclusions of this article. (XLSX 94 kb