BRS Invariance of Unoriented Open-Closed String Field Theory

We present the full action for the unoriented open-closed string field theory which is based on the \alpha=p^+ HIKKO type vertices. The BRS invariance of the action is proved up to the terms which are expected to cancel the anomalous one-loop contributions. This implies that the system is invariant under the gauge transformations with open and closed string field parameters up to the anomalies.Comment: 53 pages, LaTeX with PTPTeX.sty, 23 eps figures, style file replace

On the Generalized Gluing and Resmoothing Theorem

The generalized gluing and resmoothing theorem originally proved by LeClair, Peskin and Preitschopf, gives a powerful formula for the fused vertex obtained by contracting any two vertices in string field theories. Although the theorem is naturally expected to hold for the vertices at any loop level, the original proof was restricted to the vertices at tree level. Here we present a simplified proof for the tree level theorem and then prove explicitly the extended version at one-loop level. We also find that a non-trivial sign factor, which depends on the string states to be contracted, appears in the theorem. This sign factor turns out to be essential for reproducing correctly the conformal field theory correlation function on the torus.Comment: 19 pages, LaTeX with PTPTeX.sty, 3 eps figure

One-Loop Tachyon Amplitude in Unoriented Open-Closed String Field Theory

We calculate one-loop 2-point tachyon amplitudes in unoriented open-closed string field theory, and determine all the coupling constants of the interaction vertices in the theory. It is shown that the planar, nonplanar and nonorientable amplitudes are all reproduced correctly, and nontrivial consistencies between the determined coupling constants are observed. The necessity for the gauge group to be SO(2^{13}=8192) is also reconfirmed.Comment: 40 pages, 17 eps figures, LaTeX with PTPTeX.sty, style file replaced once again

Chiral phase transition in an extended NJL model with higher-order multi-quark interactions

The chiral phase transition is studied in an extended Nambu--Jona-Lasinio model with eight-quark interactions. Equations for scalar and vector quark densities, derived in the mean field approximation, are nonlinear and mutually coupled. The scalar-type nonlinear term hastens the restoration of chiral symmetry, while the scalar-vector mixing term makes the transition sharper. The scalar-type nonlinear term shifts the critical endpoint toward the values predicted by lattice QCD simulations and the QCD-like theory.Comment: 11pages, 7 figure

Fibrillary Glomerulopathy with a High Level of Myeloperoxidase-ANCA: A Case Report

An elderly woman was admitted with the chief complaint of gross hematuria. Laboratory values indicated a high myeloperoxidase-ANCA level. In renal histological examination, 40% of the glomeruli showed crescent formation, but immunofluorescence staining showed positivity for IgG, C3, and C1q. Furthermore, the deposition of fibrils in the glomerulus was noted on electron microscopy, and immunohistochemical staining showed strong positivity for DNA-J heat shock protein family member B9 (DNAJB9). Crescent formation is a common feature of fibrillary glomerulonephritis (FGN). Thus, in ANCA-positive crescentic glomerulonephritis, immunohistochemical assessments for immunoglobulins and DNAJB9, as well as electron microscopy, are important to correctly diagnose FGN

Autoimmune Factor V Deficiency That Took 16 Years to Diagnose due to Pseudodeficiency of Multiple Coagulation Factors

A 70-year-old man presented to our hospital with intramuscular hemorrhage in the right thigh. He had exhibited a tendency to bleed for the last 16 years and had visited several medical institutions, but no diagnosis had been made. Since the risk of sudden bleeding was assumed to be high due to his age, we decided to examine him in our department. A coagulation abnormality with prothrombin time-international normalized ratio (PT-INR) of 4.5 and activated partial thromboplastin time (aPTT) of 99.6 seconds was observed, but the platelet count, fibrinogen, and PIVKAII were within normal limits. Coagulation activities of factor V, VII, VIII, IX, X, XI, XII, and XIII were all reduced. Anti-factor VIII and IX antibodies which were measured by the Bethesda method, lupus anti-coagulant (diluted Russell snake venom time method) and anti-cardiolipin antibody were also positive. The results of these tests were comparable to those undertaken 15 years ago when they were scrutinized at the university hospital. We suspected the presence of anti-factor V antibodies because there was a dissociation between the thrombotest values measured and those calculated from the PT-INR. Moreover, cross-mixing test showed an immediate inhibitor pattern. Subsequently, factor V antibodies were confirmed by the immunoblot method and the diagnosis of autoimmune factor V deficiency was made. When factor V, which is downstream of the coagulation cascade, is inhibited, coagulation test using the one-stage clotting method shows a pseudolow value. Therefore, extensive abnormalities of coagulation factor activity and inhibitor assay should be interpreted with caution, and the presence of a high titer of factor V inhibitor should be considered

Azathioprine Hypersensitivity Syndrome during Treatment of Severe Interstitial Lung Disease with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis

Azathioprine is used to treat anti-neutrophil cytoplasmic antibody- (ANCA-) associated vasculitis. Azathioprine hypersensitivity syndrome is often missed. An 81-year-old man undergoing treatment for interstitial pneumonia developed a high fever and was diagnosed with ANCA-associated vasculitis based on an elevated myeloperoxidase- (MPO-) ANCA titer and renal biopsy findings. After induction therapy, his clinical symptoms improved, but his MPO-ANCA remained elevated (>300 U·L-1) and hematuria persisted. Prednisolone plus azathioprine was administered as maintenance therapy. Three exacerbations of the inflammatory response occurred during the subsequent 3 months. In each instance, we suspected opportunistic infection or a flare-up of vasculitis. The first exacerbation was treated with an increased prednisolone dose and antibiotics. At the onset of the second exacerbation, which was accompanied by systemic erythema, we stopped azathioprine and administered antibiotics. The third exacerbation, which occurred the day after restarting azathioprine, involved a fever with chills and an acute inflammatory reaction; we therefore suspected an azathioprine allergy. A drug provocation test was performed, and a hyperinflammatory response was observed. The patient received prednisolone (15 mg·day-1) monotherapy; no further fever was observed during the subsequent 2 months. We therefore diagnosed azathioprine hypersensitivity syndrome. Under treatment with prednisolone (5 mg·day-1) and mycophenolate mofetil (1 g·day-1) (replacing the azathioprine), no signs of relapse or infection have occurred for more than two years. Renal function and the pulmonary lesions are stable, although the high MPO-ANCA titer and hematuria persist. The diagnosis of azathioprine hypersensitivity is often delayed because of the difficulty in identifying the relationship between immunosuppressive agents and hypersensitivity and in distinguishing this from infection or relapse of the primary disease. The misdiagnosis of azathioprine hypersensitivity leads to unnecessary treatment; thus, clinicians should consider allergic reactions specific to azathioprine when switching from induction to maintenance therapy

Cardiac angiosarcoma with metastatic to lung, brain, and bone

Cardiac angiosarcoma is a malignant tumor derived from vascular endothelium with a dismal prognosis. The imaging findings of cardiac angiosarcoma are nonspecific and endomyocardial and pericardial biopsies have insufficient accuracy. For these reasons, the diagnosis is sometimes difficult. Primary and metastatic tumors tend to bleed easily, causing hemoptysis and neurological symptoms. Brain metastases are not often known to be fatal when they cause hemorrhage. We report a 27-year-old man diagnosed with right atrium angiosarcoma, with metastases in the lung, brain, and bone. The patient had only respiratory symptoms at the first visit and did not show any symptoms derived from brain metastases yet died after 27 days due to hemorrhage from brain metastases. If brain metastasis from angiosarcoma is suspected based on imaging findings, urgent radiotherapy should be considered before histological examination for a definitive diagnosis