Self-joining of Y-TZP by flash event under an AC electric field

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Lack of impact of the ALDH2 rs671 variant on breast cancer development in Japanese BRCA1/2‐mutation carriers

The aldehyde degrading function of the ALDH2 enzyme is impaired by Glu504Lys polymorphisms (rs671, termed A allele), which causes alcohol flushing in east Asians, and elevates the risk of esophageal cancer among habitual drinkers. Recent studies suggested that the ALDH2 variant may lead to higher levels of DNA damage caused by endogenously generated aldehydes. This can be a threat to genome stability and/or cell viability in a synthetic manner in DNA repair-defective settings such as Fanconi anemia (FA). FA is an inherited bone marrow failure syndrome caused by defects in any one of so far identified 22 FANC genes including hereditary breast and ovarian cancer (HBOC) genes BRCA1 and BRCA2. We have previously reported that the progression of FA phenotypes is accelerated with the ALDH2 rs671 genotype. Individuals with HBOC are heterozygously mutated in either BRCA1 or BRCA2, and the cancer-initiating cells in these patients usually undergo loss of the wild-type BRCA1/2 allele, leading to homologous recombination defects. Therefore, we hypothesized that the ALDH2 genotypes may impact breast cancer development in BRCA1/2 mutant carriers. We genotyped ALDH2 in 103 HBOC patients recruited from multiple cancer centers in Japan. However, we were not able to detect any significant differences in clinical stages, histopathological classification, or age at clinical diagnosis across the ALDH2 genotypes. Unlike the effects in hematopoietic cells of FA, our current data suggest that there is no impact of the loss of ALDH2 function in cancer initiation and development in breast epithelium of HBOC patients

Growth and structure analysis of tungsten oxide nanorods using environmental TEM

WO3 nanorods targeted for applications in electric devices were grown from a tungsten wire heated in an oxygen atmosphere inside an environmental transmission electron microscope, which allowed the growth process to be observed to reveal the growth mechanism of the WO3 nanorods. The initial growth of the nanorods did not consist of tungsten oxide but rather crystal tungsten. The formed crystal tungsten nanorods were then oxidized, resulting in the formation of the tungsten oxide nanorods. Furthermore, it is expected that the nanorods grew through cracks in the natural surface oxide layer on the tungsten wire

Plasma induced tungsten doping of TiO2 particles for enhancement of photocatalysis under visible light

Here we report a novel method for modifying commercially available TiO2 nanoparticles by a microwave-induced plasma technique. After the plasma treatment TiO2 nanoparticles showed enhanced visible absorption due to the doped W atoms, and the photocatalytic methylene blue degradation above 440 nm was successfully improved

In Situ Transmission Electron Microscopic Observation of Double-wall TiO2 Nanotube Arrays at High Temperature

Double-wall TiO2 nanotube arrays were prepared using an anodization method in a glycerol-containing electrolyte. In situ TEM observation of these samples at high temperature was carried out with and without oxygen injections. With oxygen injection, an improved thermal stability of the nanotubes at high temperature was observed. It may provide more detailed information about the calcination process of TiO2 nanotubes and assist its morphology and structure modulation