Towards elucidation of zero-temperature criticality of the Ising model on 2D dynamical triangulations

We study the zero-temperature criticality of the Ising model on two-dimensional dynamical triangulations to contemplate its physics. As it turns out, an inhomogeneous nature of the system yields an interesting phase diagram and the physics at the zero temperature is quite sensitive about how we cool down the system. We show the existence of a continuous parameter that characterizes the way we approach the zero-temperature critical point and it may enter in a critical exponent.Comment: 20 pages, 4 figures; minor corrections; Introduction and Discussion expande

Linear Gyrokinetic Analyses of ITG Modes and Zonal Flows in LHD with High Ion Temperature

Ion temperature (Ti) gradient modes (ITG modes) and zonal flows for high Ti discharges in the Large Helical Device (LHD) are investigated by linear gyrokinetic Vlasov simulation. In recent LHD experiments, high Ti plasmas are generated by neutral beam injection, and spatial profiles of density fluctuations are measured by phase contrast imaging (PCI) [K. Tanaka et al., Plasma Fusion Res. 5, S2053 (2010)]. The observed fluctuations most likely propagate in the direction of the ion diamagnetic rotation in the plasma frame, and their amplitudes increase with the growth of the temperature gradient. The results show the characteristics of ITG turbulence. To investigate the ITG modes and zonal flows in the experiment, linear gyrokinetic simulations were performed in the corresponding equilibria with different Ti profiles by using the GKV-X code [M. Nunami et al., Plasma Fusion Res. 5, 016 (2010)]. The simulation results predict unstable regions for the ITG modes in radial, wavenumber, and phase velocity spaces, in agreement with the PCI measurements. Thus, the fluctuations observed in the experiment are attributed to ITG instability. The responses of the zonal flows show clear contrasts in different field spectra that depend on the Ti profile and the radial position. In addition to the dependence on the field spectra, the zonal flow residual levels are enhanced by increasing the radial wavenumber as theoretically predicted

Efficacy of vonoprazan against bleeding from endoscopic submucosal dissection-induced gastric ulcers under antithrombotic medication: A cross-design synthesis of randomized and observational studies

Vonoprazan, a potassium-competitive acid blocker, is expected to be superior to proton pump inhibitors (PPIs) in preventing post-endoscopic submucosal dissection (ESD)-induced gastric bleeding. However, the results of randomized controlled trials (RCTs) and observational studies on the efficacy of vonoprazan have been inconsistent. This study aimed to evaluate the effectiveness of vonoprazan in antithrombotic drug users, a population that has been excluded from RCTs. Treatment effects were assessed using cross-design synthesis, which can be adjusted for differences in study design and patient characteristics. We used data from an RCT in Japan (70 patients in the vonoprazan group and 69 in the PPI group) and an observational study (408 patients in the vonoprazan group and 870 in the PPI group). After matching, among the antithrombotic drug users in the observational study, post-ESD bleeding was noted in 8 out of 86 patients in the vonoprazan group and 18 out of 86 patients in the PPI group. After pooling the data from the RCT and observational study, the risk difference for antithrombotic drug users was -14.6% (95% CI: -22.0 to -7.2). CDS analysis suggested that vonoprazan is more effective than PPIs in preventing post-ESD bleeding among patients administered antithrombotic medications

Alterations in photosynthetic pigments and amino acid composition of D1 protein change energy distribution in photosystem II

AbstractThe marine cyanobacterium Prochlorococcus marinus accumulates divinyl chlorophylls instead of monovinyl chlorophylls to harvest light energy. As well as this difference in its chromophore composition, some amino acid residues in its photosystem II D1 protein were different from the conserved amino acid residues in other photosynthetic organisms. We examined PSII complexes isolated from mutants of Synechocystis sp. PCC 6803, in which chromophore and D1 protein were altered (Hisashi Ito and Ayumi Tanaka, 2011) to clarify the effects of chromophores/D1 protein composition on the excitation energy distribution. We prepared the mutants accumulating divinyl chlorophyll (DV mutant). The amino acid residues of V205 and G282 in the D1 protein were substituted with M205 and C282 in the DV mutant to mimic Prochlorococcus D1 protein (DV-V205M/G282C mutant). Isolated PSII complexes were analyzed by time-resolved fluorescence spectroscopy. Energy transfer in CP47 was interrupted in PSII containing divinyl chlorophylls. The V205M/G282C mutation did not recover the energy transfer pathway in CP47, instead, the mutation allowed the excitation energy transfer from CP43 to CP47, which neighbors in the PSII dimer. Mutual orientation of the subcomplexes of PSII might be affected by the substitution. The changes of the energy transfer pathways would reduce energy transfer from antennae to the PSII reaction center, and allow Prochlorococcus to acquire light tolerance

Black hole entropy for the general area spectrum

We consider the possibility that the horizon area is expressed by the general area spectrum in loop quantum gravity and calculate the black hole entropy by counting the degrees of freedom in spin-network states related to its area. Although the general area spectrum has a complex expression, we succeeded in obtaining the result that the black hole entropy is proportional to its area as in previous works where the simplified area formula has been used. This gives new values for the Barbero-Immirzi parameter ($\gamma =0.5802... \mathrm{or} 0.7847...$) which are larger than that of previous works.Comment: 5 page

白内障手術既往のある高齢者は視力と独立して高い認知機能を維持する : 平城京コホート研究横断解析

Cataract surgery improves visual acuity and drastically increases the capacity for light reception to the retina. Although previous studies suggested that both light exposure and visual acuity were associated with cognitive function, the relationships between cataract surgery, visual acuity, and cognitive function have not been evaluated in large populations. In this cross-sectional study, we measured cognitive function using the Mini-Mental State Examination and best-corrected visual acuity in pseudophakic (previous cataract surgery) and phakic (no previous cataract surgery) elderly individuals. Of 945 participants (mean age 71.7 years), 166 (17.6%) had pseudophakia and 317 (33.5%) had impaired cognitive function (score ≤26). The pseudophakic group showed significantly better visual acuity than the phakic group (p = 0.003) and lower age-adjusted odds ratio (ORs) for cognitive impairment (OR 0.66; p = 0.038). Consistently, in multivariate logistic regression models, after adjusting for confounding factors, including visual acuity and socioeconomic status, ORs for cognitive impairment were significantly lower in the pseudophakic group than in the phakic group (OR 0.64; 95% confidence interval 0.43-0.96; p = 0.031). This association remained significant in sensitivity analysis, excluding participants with low cognitive score ≤23 (n = 36). In conclusion, in a general elderly population, prevalence of cognitive impairment was significantly lower in pseudophakic individuals independently of visual acuity. The association was also independent of several major causes of cognitive impairment such as aging, gender, obesity, socioeconomic status, hypertension, diabetes, sleep disturbances, depressive symptoms, and physical inactivity.博士（医学）・甲第666号・平成29年3月15日© Mary Ann Liebert, Inc.This is a non-final version of an article published in final form in "http://dx.doi.org/10.1089/rej.2015.1718

Turbulent transport of heat and particles in a high ion temperature discharge of the Large Helical Device

Turbulent transport in a high ion temperature discharge of the Large Helical Device (LHD) is investigated by means of electromagnetic gyrokinetic simulations, which include kinetic electrons, magnetic perturbations, and full geometrical effects. Including kinetic electrons enables us to firstly evaluate the particle and the electron heat fluxes caused by turbulence in LHD plasmas. It is found that the electron energy transport reproduces the experimental result, and that the particle flux is negative. The contribution of magnetic perturbation to the transport is small because of very low beta. The turbulence is driven by the ion temperature gradient instability, and the effect of kinetic electrons enhances the growth rate larger than that from the adiabatic electron calculation. The ion energy flux is larger than that observed in the experiment, while the flux is close to the experimental observation when the temperature gradient is reduced 20% in the simulation. This significant sensitivity of the energy flux implies that the profile in the experiment is close to the critical temperature gradient. The critical gradient for turbulent energy flux is similar to that for the linear instability, i.e., the Dimits shift is small. This is because the zonal flow in the LHD is weaker than that in tokamaks

An Arabidopsis SBP-domain fragment with a disrupted C-terminal zinc-binding site retains its tertiary structure

AbstractSQUAMOSA promoter-binding proteins (SBPs) form a major family of plant-specific transcription factors, mainly related to flower development. SBPs share a highly conserved DNA-binding domain of ∼80 amino acids (SBP domain), which contains two non-interleaved zinc-binding sites formed by eight conserved Cys or His residues. In the present study, an Arabidopsis SPL12 SBP-domain fragment that lacks a Cys residue involved in the C-terminal zinc-binding pocket was found to retain a folded structure, even though only a single Zn2+ ion binds to the fragment. Solution structure of this fragment determined by NMR is very similar to the previously determined structures of the full SBP domains of Arabidopsis SPL4 and SPL7. Considering the previous observations that chelating all the Zn2+ ions of SBPs resulted in the complete unfolding of the structure and that a mutation of the Cys residue equivalent to that described above impaired the DNA-binding activity, we propose that the Zn2+ ion at the N-terminal site is necessary to maintain the overall tertiary structure, while the Zn2+ ion at the C-terminal site is necessary for the DNA binding, mainly by guiding the basic C-terminal loop to correctly fit into the DNA groove