Retinal development during the third larval instar of Drosophila Melanogaster

One of the major aims of the developmental biologist is to establish how a highly complex multicellular organism is derived from its unicellular zygotic origin. This thesis describes an investigation into the retinal development of Drosophila melanogaster during its third larval instar in an attempt to understand how the highly ordered and complex cellular constitution of the retina is established from a group of unorganised and undifferentiated cells. The text is divided into six chapters. The first chapter is a review of the literature germane to the problem being investigated, and the second deals with the experimental methodology adopted. The remaining chapters relate the experimental findings and their implications to the problem under investigation. Chapter Three describes the main body of the research, which consists of an electron microscopic serial section investigation of the developing retinal tissue, and the utilisation of computer graphic reconstruction techniques to give a comprehensive understanding of the three dimensional cellular arrangements. The fourth chapter deals with autoradiographical studies which were undertaken to resolve an incongruity between a finding from the electron microscopic studies and an earlier literature report. Chapter Five relates an investigation into the mutation sevenless which was performed in an attempt to both assess the value of knowledge acquired from the earlier investigations, and to understand the developmental failure that leads to this particular mutant phenotype. The last chapter is a brief summary of how the retinal development during the third larval instar is better understood after the investigations described in this thesis

Patents and The Regress of Useful Arts

Patent systems are often justified by an assumption that innovation will be spurred by the prospect of patent protection, leading to the accrual of greater societal benefits than would be possible under non-patent systems. However, little empirical evidence exists to support this assumption. One way to test the hypothesis that a patent system promotes innovation is to simulate the behavior of inventors and competitors experimentally under conditions approximating patent and non-patent systems. Employing a multi-user interactive simulation of patent and non-patent (commons and open source) systems ("PatentSim"), this study compares rates of innovation, productivity, and societal utility. PatentSim uses an abstracted and cumulative model of the invention process, a database of potential innovations, an interactive interface that allows users to invent, patent, or open source these innovations, and a network over which users may interact with one another to license, assign, buy, infringe, and enforce patents. Data generated thus far using PatentSim suggest that a system combining patent and open source protection for inventions (that is, similar to modern patent systems) generates significantly lower rates of innovation (p<0.05), productivity (p<0.001), and societal utility (p<0.002) than does a commons system. These data also indicate that there is no statistical difference in innovation, productivity, or societal utility between a pure patent system and a system combining patent and open source protection. The results of this study are inconsistent with the orthodox justification for patent systems. However, they do accord well with evidence from the increasingly important field of user and open innovation. Simulation games of the patent system could even provide a more effective means of fulfilling the Constitutional mandate "to promote the Progress of . . . useful Arts" than does the orthodox assumption that technological innovation can be encouraged through the prospect of patent protection

If We Could Talk to the Animals, How Should We Discuss Their Legal Rights?

The intricate tapestry of animal communication has long fascinated humanity, with the sophisticated linguistics of cetaceans holding a special place of intrigue due to the cetaceans’ significant brain size and apparent intelligence. This Essay explores the legal implications of the recent advancements in artificial intelligence (AI), specifically machine learning and neural networks, that have made significant strides in deciphering sperm whale (Physeter macrocephalus) communication. We view the ability of a being to communicate as one—but not the only—potential pathway to qualify for legal rights. As such, we investigate the possibility that the ability to communicate should trigger legal rights for beings capable of communicating, whether they be cetaceans or other creatures. As the Cetacean Translation Initiative (CETI) project, which is actively working to unlock sperm whale language, moves closer to enabling meaningful human-cetacean dialogue, we stand on the precipice of a transformative understanding that may compel a radical reevaluation of animal legal rights and, perhaps, human legal rights as well. In fact, viewing eligibility for legal rights through a more objective lens, such as a communication criterion, may even improve our understanding of human legal rights, their origins, extent, application, and even entitlement itself. We begin with an overview of animal communication, emphasizing the complex acoustic patterns of sperm whale songs and clicks, which have been captured and analyzed through the collaborative efforts of marine biologists and computer scientists. This cross-disciplinary effort has yielded what the Dominica Sperm Whale Project has named “Flukebook”—a robust dataset that informs machine-learning models with acoustic signals, contextual behavioral data, genetic data, and geospatial information—that opens the door to the potential of an interspecies large language model (LLM) useful for communication among sperm whales and humans. Having established that the prospect of communicating with another species is becoming increasingly feasible, we then delve into the philosophical and ethical considerations that accompany such a breakthrough. Drawing upon the perspectives of thinkers such as Jeremy Bentham, Professor Peter Singer, and Professor Martha Nussbaum, we investigate the ethical foundations for considering the legal rights of cetaceans, or other nonhuman animals. This investigation is juxtaposed with historical whaling laws and modern legal frameworks, probing the adequacy of current laws, norms, practices, and attitudes regarding emerging interspecies communication. Finally, we propose a novel legal paradigm that contends with the implications of cetacean communication capabilities. As we inch toward potentially understanding requests, preferences, or even rules or laws of sperm whales, the ethical imperative to reexamine their legal standing becomes undeniable. This Essay examines practical legal issues such as jurisdiction, standing, representation, autonomy, and the feasibility of animal citizenship. In fact, it envisions innovative legal constructs such as a “Magna Carta Cetacea” and a “United Species” extension of the United Nations. In addition, we endeavor to articulate an objective standard by which any being capable of the requisite communication qualifies for legal rights. In this potential legal frontier, the communication of preferences by an animal may necessitate that we seriously consider conferring legal rights to those animals. This groundbreaking dialogue could not only elevate the rights of whales, but also provoke a broader discussion about the principles underlying human legal rights themselves, challenging our current anthropocentric legal systems to evolve. As we decode the “codas” of sperm whales, we are challenged to reenvision the legal and normative matrix of life on Earth and our place within it, guided by potential principles such as mutual respect and legal recognition that transcend species boundaries

Training is Everything: Artificial Intelligence, Copyright, and “Fair Training”

In this Essay, we analyze the arguments in favor of, and against, viewing the use of copyrighted works in training sets for AI as fair use. We call this form of fair use “fair training.” We identify both strong and spurious arguments on both sides of this debate. In addition, we attempt to take a broader perspective, weighing the societal costs (e.g., replacement of certain forms of human employment) and benefits (e.g., the possibility of novel AI-based approaches to global issues such as environmental disruption) of allowing AI to make easy use of copyrighted works as training sets to facilitate the development, improvement, adoption, and diffusion of AI. Finally, we suggest that the debate over AI and copyrighted works may be a tempest in a teapot when placed in the wider context of massive societal challenges such as poverty, inequality, climate change, and loss of biodiversity, to which AI may be part of the solution

Fault Lines: An Empirical Legal Study of California Secession

Over the last decade, multiple initiatives have proposed that California should secede from the United States. This article examines the legal aspects of California secession and integrates that analysis with findings from an empirical study of public perceptions of such secession. There is no provision in the United States Constitution allowing states, or other political or geographical units, to secede unilaterally. The Civil War was fought to uphold this principle, and the United States Supreme Court confirmed it in its 1869 Texas v. White decision. Nevertheless, numerous instances of secession, both legal and extralegal, have occurred across human history, and there is continuing public interest in secession of various U.S. states, in particular California. We conducted an empirical study with 100 U.S. residents, half from California and half from other U.S. states, via Amazon’s crowdsourcing platform. We found that, while most participants (71%) opposed secession, a significant minority (25%) were in favor of it, with the remainder (4%) unsure. In addition, older people, and people who did not live in California, were statistically more inclined toward secession (37% in both cases) than were younger people (13%) and Californians (15%). Participants identified an array of themes relevant to California secession, including California being an “essential, vital component” of the U.S.; California being “indebted” to the U.S.; the U.S. keeping California “in check”; logistical factors such as “currencies,” “infrastructures,” “trade agreements,” and “a new military”; the “growing fascistic tendencies” of the U.S.; and feelings that California should “fend for themselves.” Other personal/idiosyncratic factors emerged as well, including residents’ concern about needing to “speak Spanish,” it becoming harder to “sell on eBay,” and that the “flags would need to be changed.” Still others were concerned about “violent confrontation” and “civil war.” Taken together, the legal and empirical factors paint a picture of the complexity of California secession, and offer insight into this and other instances of potential sociopolitical breakdown. Although unilateral secession would be illegal under U.S. law, we explore a number of peaceful secessions around the world, and abstract principles from them that may be helpful if California secession were ever to become a possibility. The numerous lines of argument provided by participants in this study, many of which find fault with the directions either of California or the rest of the U.S., help identify the stresses that could cause California to shear off and become a separate nation. While California would be the epicenter of this phenomenon, its aftershocks would likely be felt around the world

Application Of Ultrasonic Technology To Improve The Reliability Of Magnetic-Drive Centrifugal Pumps

LectureIt is widely acknowledged that sealless magnetic drive pumps give total containment of the pumped process liquid, which in an industry where there are ever tightening environmental constraints on plant operation and increasing health and safety requirements, offers a real advantage of reliability and safety to users. However, as with any piece of process machinery, magnetic drive pumps are designed to operate within specific parameters and operation outside of these parameters can lead to reduced levels of reliability. Whilst traditional instrumentation (measurement of temperature or power) will assist in improving the reliability of the machine, these instruments are not monitoring the primary cause of the issue; instead they are monitoring the effect that the fault condition has on another part of the machine. By constantly monitoring the condition of the pumped liquid present in the internal flow regime of a magnetic-drive pump, it is possible to rapidly identify potential issues and react to them accordingly. Ultrasonic technology has been utilised to rapidly and accurately detect the presence of vapour in the liquid stream. The technology provides a precise and sensitive response to even the smallest change in phase, therefore improving the overall reliability of the machine. This paper presents an overview of the ultrasonic technology that has been utilised to monitor the condition of magnetic-drive centrifugal pumps, including highlights of extensive testing that has been carried out and some real world examples involving the application of this technology on volatile light hydrocarbon processes

Student expectations of teaching and learning when starting university: a systematic review

Student expectations are complex constructs that can influence adaptability, engagement, achievement, satisfaction and retention. A number of individual studies have been published on the expectations of students when starting university, however none that synthesise student expectations of teaching and learning. Therefore, the aim of this systematic review was to understand student expectations of teaching and learning when starting university. A systematic search strategy identified 2950 studies, of which nine met all eligibility criteria. Relevant data was extracted and a narrative synthesis conducted, revealing four key themes: additional study, self-managing learning, teaching and learning activities, and accessibility. Students expect to complete additional study and take responsibility for their own learning, but may be unsure how to manage this. They expect to have to attend all sessions and commonly expect lectures, but thoughts on other methods of teaching and learning vary. Students also have high expectations of teaching staff, particularly with regards to access and resources. This knowledge is important in enabling teaching staff to better align preconceived ideas of university teaching and learning with reality, support a positive university experience, and improve satisfaction and retention. Future research should further investigate student expectations of teaching and learning independently, perhaps from a qualitative perspective, as well as exploring interventions to help manage these expectations when necessary