1,037 research outputs found
Effect of nano-scale surface roughness on transverse energy spread from GaAs photocathodes
High quantum yield, low transverse energy spread and prompt response time
make GaAs activated to negative electron affnity, an ideal candidate for a
photocathode in high brightness photoinjectors. Even after decades of
investigation, the exact mechanism of electron emission from GaAs is not well
understood. We show that a nanoscale surface roughness can affect the
transverse electron spread from GaAs by nearly an order of magnitude and
explain the seemingly controversial experimental results obtained so far. This
model can also explain the measured dependence of transverse energy spread on
the wavelength of incident light.Comment: 3pages, 3figure
Wave-vector and polarization dependence of conical refraction
We experimentally address the wave-vector and polarization dependence of the
internal conical refraction phenomenon by demonstrating that an input light
beam of elliptical transverse profile refracts into two beams after passing
along one of the optic axes of a biaxial crystal, i.e. it exhibits double
refraction instead of refracting conically. Such double refraction is
investigated by the independent rotation of a linear polarizer and a
cylindrical lens. Expressions to describe the position and the intensity
pattern of the refracted beams are presented and applied to predict the
intensity pattern for an axicon beam propagating along the optic axis of a
biaxial crystal
Topology Change of Coalescing Black Holes on Eguchi-Hanson Space
We construct multi-black hole solutions in the five-dimensional
Einstein-Maxwell theory with a positive cosmological constant on the
Eguchi-Hanson space, which is an asymptotically locally Euclidean space. The
solutions describe the physical process such that two black holes with the
topology of S^3 coalesce into a single black hole with the topology of the lens
space L(2;1)=S^3/Z_2. We discuss how the area of the single black hole after
the coalescence depends on the topology of the horizon.Comment: 10 pages, Some comments are added. to be published as a letter in
Classical and Quantum Gravit
Charged Rotating Kaluza-Klein Black Holes Generated by G2(2) Transformation
Applying the G_{2(2)} generating technique for minimal D=5 supergravity to
the Rasheed black hole solution, we present a new rotating charged Kaluza-Klein
black hole solution to the five-dimensional Einstein-Maxwell-Chern-Simons
equations. At infinity, our solution behaves as a four-dimensional flat
spacetime with a compact extra dimension and hence describes a Kaluza-Klein
black hole. In particlar, the extreme solution is non-supersymmetric, which is
contrast to a static case. Our solution has the limits to the asymptotically
flat charged rotating black hole solution and a new charged rotating black
string solution.Comment: 24 page
A cautionary tale: the non-causal association between type 2 diabetes risk SNP, rs7756992, and levels of non-coding RNA, CDKAL1-v1
Journal ArticleCopyright © The Author(s) 2015. This article is published with open access at Springerlink.com.Aims/hypothesis: Intronic single nucleotide polymorphisms (SNPs) in the CDKAL1 gene are associated with risk of developing type 2 diabetes. A strong correlation between risk alleles and lower levels of the non-coding RNA, CDKAL1-v1, has recently been reported in whole blood extracted from Japanese individuals. We sought to replicate this association in two independent cohorts: one using whole blood from white UK-resident individuals, and one using a collection of human pancreatic islets, a more relevant tissue type to study with respect to the aetiology of diabetes. Methods: Levels of CDKAL1-v1 were measured by real-time PCR using RNA extracted from human whole blood (n = 70) and human pancreatic islets (n = 48). Expression with respect to genotype was then determined. Results: In a simple linear regression model, expression of CDKAL1-v1 was associated with the lead type 2 diabetes-associated SNP, rs7756992, in whole blood and islets. However, these associations were abolished or substantially reduced in multiple regression models taking into account rs9366357 genotype: a moderately linked SNP explaining a much larger amount of the variation in CDKAL1-v1 levels, but not strongly associated with risk of type 2 diabetes. Conclusions/interpretation: Contrary to previous findings, we provide evidence against a role for dysregulated expression of CDKAL1-v1 in mediating the association between intronic SNPs in CDKAL1 and susceptibility to type 2 diabetes. The results of this study illustrate how caution should be exercised when inferring causality from an association between disease-risk genotype and non-coding RNA expression.MRCNIH
A cautionary tale: the non-causal association between type 2 diabetes risk SNP, rs7756992, and levels of non-coding RNA, CDKAL1-v1
This is the final version of the article. Available from Springer Verlag via the DOI in this record.AIMS/HYPOTHESIS: Intronic single nucleotide polymorphisms (SNPs) in the CDKAL1 gene are associated with risk of developing type 2 diabetes. A strong correlation between risk alleles and lower levels of the non-coding RNA, CDKAL1-v1, has recently been reported in whole blood extracted from Japanese individuals. We sought to replicate this association in two independent cohorts: one using whole blood from white UK-resident individuals, and one using a collection of human pancreatic islets, a more relevant tissue type to study with respect to the aetiology of diabetes. METHODS: Levels of CDKAL1-v1 were measured by real-time PCR using RNA extracted from human whole blood (n = 70) and human pancreatic islets (n = 48). Expression with respect to genotype was then determined. RESULTS: In a simple linear regression model, expression of CDKAL1-v1 was associated with the lead type 2 diabetes-associated SNP, rs7756992, in whole blood and islets. However, these associations were abolished or substantially reduced in multiple regression models taking into account rs9366357 genotype: a moderately linked SNP explaining a much larger amount of the variation in CDKAL1-v1 levels, but not strongly associated with risk of type 2 diabetes. CONCLUSIONS/INTERPRETATION: Contrary to previous findings, we provide evidence against a role for dysregulated expression of CDKAL1-v1 in mediating the association between intronic SNPs in CDKAL1 and susceptibility to type 2 diabetes. The results of this study illustrate how caution should be exercised when inferring causality from an association between disease-risk genotype and non-coding RNA expression.This paper presents independent research funded by the Medical
Research Council (grant number MR/J006777/1) and supported
by the National Institute for Health Research (NIHR) Exeter Clinical
Research Facility. The views expressed are those of the authors and not
necessarily those of the Medical Research Council, UK National Health
Service, NIHR or the UK Department of Health
On the dual-cone nature of the conical refraction phenomenon
In conical refraction (CR), a focused Gaussian input beam passing through a biaxial crystal and parallel to one of the optic axes is transformed into a pair of concentric bright rings split by a dark (Poggendorff) ring at the focal plane. Here, we show the generation of a CR transverse pattern that does not present the Poggendorff fine splitting at the focal plane, i.e., it forms a single light ring. This light ring is generated from a nonhomogeneously polarized input light beam obtained by using a spatially inhomogeneous polarizer that mimics the characteristic CR polarization distribution. This polarizer allows modulating the relative intensity between the two CR light cones in accordance with the recently proposed dual-cone model of the CR phenomenon. We show that the absence of interfering rings at the focal plane is caused by the selection of one of the two CR cones. (C) 2015 Optical Society of Americ
Enhancement of Resonant Thermonuclear Reaction Rates in Extremely Dense Stellar Plasmas
The enhancement factor of the resonant thermonuclear reaction rates is
calculated for the extremely dense stellar plasmas in the liquid phase. In
order to calculate the enhancement factor we use the screening potential which
is deduced from the numerical experiment of the classical one-component plasma.
It is found that the enhancement is tremendous for white dwarf densities if the
^{12}C + ^{12}C fusion cross sections show resonant behavior in the
astrophysical energy range. We summarize our numerical results by accurate
analytic fitting formulae.Comment: 13 pages, 3 figures, accepted for publication in ApJ, replaced with
revised versio
Sequences of dipole black rings and Kaluza-Klein bubbles
We construct new exact solutions to 5D Einstein-Maxwell equations describing
sequences of Kaluza-Klein bubbles and dipole black rings. The solutions are
generated by 2-soliton transformations from vacuum black ring - bubble
sequences. The properties of the solutions are investigated. We also derive the
Smarr-like relations and the mass and tension first laws in the general case
for such configurations of Kaluza-Klein bubbles and dipole black rings. The
novel moment is the appearance of the magnetic flux in the Smarr-like relations
and the first laws.Comment: 26 pages, 1 figur
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