Rapid Assessment of Reward-Related Eating: The RED-X5.

OBJECTIVE:The prevalence of obesity has created a plethora of questionnaires characterizing psychological aspects of eating behavior, such as reward-related eating (RRE). The Reward-based Eating Drive questionnaires (RED-9, RED-13) broadly and deeply assess the RRE construct. However, large-sample research designs require shorter questionnaires that capture RRE quickly and precisely. This study sought to develop a brief, reliable, and valid version of the RED questionnaire. METHODS:All-subset correlation was used to find a subset that maximally associated with the full RED-13 in two separate samples. Results were validated in a third independent sample. Internal consistency, test-retest reliability, and ability to explain variance in external outcomes were also assessed. RESULTS:A five-item questionnaire (RED-X5) correlated strongly with RED-13 in the independent sample (r = 0.95). RED-X5 demonstrated high internal consistency (omega total ≥ 0.80) and 6-month test-retest reliability (r = 0.72). RED-X5 accurately reproduced known associations between RED-13 and BMI, diabetes status, and craving for sweet and savory foods. As a novel finding, RED questionnaires predicted laboratory intake of chips. CONCLUSIONS:RED-X5 is a short, reliable, and valid measure of the RRE construct and can be readily implemented in large-sample research designs in which questionnaire space is limited

Immunological Pathogenesis of Endolymphatic Hydrops and Its Relation to Meniere\u27s Disease

This study was designed to investigate an immunologically induced endolymphatic hydrops (ELH) and to focus on the issue of its pathogenesis in relation to Meniere\u27s disease. The time course of ELH was evaluated by light microscopy in a 2-hour to 7-month period following direct antigen challenge to the endolymphatic sac (ELS) in systemically pre-sensitized guinea pigs. ELH began to appear in the vestibule and the basal turn 5-7 hours after inner ear challenge and developed gradually. During the interval from the second day to the first week, ELH rapidly developed in all the cochlear turns and reached a maximum size. During the period from the second week to the eighth week, ELH gradually reduced. After 9 weeks, ELH of the saccule and the cochlea gradually recurred. During the interval from the first week to the eighth week, the time course of ELH correlated well with the grade of cellular infiltration of the perisaccular tissue. These results suggest that recurrent immunological reaction in the ELS may result in disorders of the ELS which finally lead to the onset of Meniere\u27s disease

Equilibrium Statistical Mechanics of Fermion Lattice Systems

We study equilibrium statistical mechanics of Fermion lattice systems which require a different treatment compared with spin lattice systems due to the non-commutativity of local algebras for disjoint regions. Our major result is the equivalence of the KMS condition and the variational principle with a minimal assumption for the dynamics and without any explicit assumption on the potential. It holds also for spin lattice systems as well, yielding a vast improvement over known results. All formulations are in terms of a C*-dynamical systems for the Fermion (CAR) algebra with all or a part of the following assumptions: (I) The interaction is even with respect to the Fermion number. (Automatically satisfied when (IV) below is assumed.) (II) All strictly local elements of the algebra have the first time derivative. (III) The time derivatives in (II) determine the dynamics. (IV) The interaction is lattice translation invariant. A major technical tool is the conditional expectation from the total algebra onto the local subalgebra for any finite subset of the lattice, which induces a system of commuting squares. This technique overcomes the lack of tensor product structures for Fermion systems and even simplifies many known arguments for spin lattice systems.Comment: 103 pages, no figure. The Section 13 has become simpler and a problem in 14.1 is settled thanks to a referee. The format has been revised according to the suggestion of this and the other referee

Long-term calorie restriction in humans is not associated with indices of delayed immunologic aging: A descriptive study.

BACKGROUND: Delayed immunologic aging is purported to be a major mechanism through which calorie restriction (CR) exerts its anti-aging effects in non-human species. However, in non-obese humans, the effect of CR on the immune system has been understudied relative to its effects on the cardiometabolic system. OBJECTIVE: To examine whether CR is associated with delayed immunologic aging in non-obese humans. METHODS: We tested whether long-term CR practitioners (average 10.03 years of CR) evidenced decreased expression of T cell immunosenescence markers and longer immune cell telomeres compared to gender-, race/ethnicity-, age-, and education-matched "healthy" Body Mass Index (BMI) and "overweight"/"obese" BMI groups. RESULTS: Long-term human CR practitioners had lower BMI (p <  0.001) and fasting glucose (p <  0.001), as expected. They showed similar frequencies of pre-senescent cells (CD8+CD28- T cells and CD57 and PD-1 expressing T cells) to the comparison groups. Even after adjusting for covariates, including cytomegalovirus status, we observed shorter peripheral blood mononuclear cell telomeres in the CR group (p = 0.012) and no difference in granulocyte telomeres between groups (p = 0.42). CONCLUSIONS: We observed no clear evidence that CR as it is currently practiced in humans delays immune aging related to telomere length or T cell immunosenescent markers

Design, modelling, simulation and integration of cyber physical systems: Methods and applications

The main drivers for the development and evolution of Cyber Physical Systems (CPS) are the reduction of development costs and time along with the enhancement of the designed products. The aim of this survey paper is to provide an overview of different types of system and the associated transition process from mechatronics to CPS and cloud-based (IoT) systems. It will further consider the requirement that methodologies for CPS-design should be part of a multi-disciplinary development process within which designers should focus not only on the separate physical and computational components, but also on their integration and interaction. Challenges related to CPS-design are therefore considered in the paper from the perspectives of the physical processes, computation and integration respectively. Illustrative case studies are selected from different system levels starting with the description of the overlaying concept of Cyber Physical Production Systems (CPPSs). The analysis and evaluation of the specific properties of a sub-system using a condition monitoring system, important for the maintenance purposes, is then given for a wind turbine

Different Types of Conditional Expectation and the Lueders - von Neumann Quantum Measurement

In operator algebra theory, a conditional expectation is usually assumed to be a projection map onto a sub-algebra. In the paper, a further type of conditional expectation and an extension of the Lueders - von Neumann measurement to observables with continuous spectra are considered; both are defined for a single operator and become a projection map only if they exist for all operators. Criteria for the existence of the different types of conditional expectation and of the extension of the Lueders - von Neumann measurement are presented, and the question whether they coincide is studied. All this is done in the general framework of Jordan operator algebras. The examples considered include the type I and type II operator algebras, the standard Hilbert space model of quantum mechanics, and a no-go result concerning the conditional expectation of observables that satisfy the canonical commutator relation.Comment: 10 pages, the original publication is available at http://www.springerlink.co