Autoimmunity to tetraspanin-7 in type 1 diabetes

Type 1 diabetes is an autoimmune disease whereby components of insulin-secreting pancreatic beta cells are targeted by the adaptive immune system leading to the destruction of these cells and insulin deficiency. There is much interest in the development of antigen-specific immune intervention as an approach to prevent disease development in individuals identified as being at risk of disease. It is now recognised that there are multiple targets of the autoimmune response in type 1 diabetes, the most recently identified being a member of the tetraspanin family, tetraspanin-7. The heterogeneity of autoimmune responses to different target antigens complicates the assessment of diabetes risk by the detection of autoantibodies, as well as creating challenges for the design of strategies to intervene in the immune response to these autoantigens. This review describes the discovery of tetraspanin-7 as a target of autoantibodies in type 1 diabetes and how the detection of autoantibodies to the protein provides a valuable marker for future loss of pancreatic beta-cell function

Infusing tribal reciprocity into service research: towards an integrated and dynamic view of repayment, retaliation and restorative justice for regenerative service ecosystem wellbeing

Service exchange among actors and the notion of reciprocity have gained momentum in service research. However, reciprocity’s underlying facets and nature have been neglected. Drawing on a tribal notion of dynamic reciprocity facilitates the understanding of contemporary service interactions in service ecosystems. We explore reciprocity’s tribal elements of repayment, retaliation and restorative justice. This tribal view of reciprocity is also linked to relational and regenerative wellbeing. We derive a conceptual framework for service ecosystems research and practice. An expanded view of reciprocity for service exchanges within and across system levels is required to facilitate regenerative service ecosystem wellbeing

Home as a Site of State-Corporate Violence: Grenfell Tower, Aetiologies and Aftermaths

Focusing on the aftermaths and consequences of the Grenfell Tower fire, this article reveals the factors which combined to produce a fire that could have such devastating effects. Further, it delineates the discrete ways in which distinct types of harms – physical, emotional and psychological, cultural and relational, and financial and economic – continue to be produced by a combination of State and corporate acts and omissions. Some of these harms are readily apparent, others are opaque and obscured. It concludes by showing how failures to mitigate these factors constitute one manifestation of the more general phenomenon of ‘social murder’

Mediating punitiveness: understanding public attitudes towards work-related fatality cases

This paper concerns an empirical investigation into public attitudes towards work-related fatality cases, where organizational offenders cause the death of workers or members of the public. This issue is particularly relevant following the introduction of the Corporate Manslaughter and Corporate Homicide Act 2007 into UK law. Here, as elsewhere, the use of criminal law against companies reflects governmental concerns over public confidence in the law’s ability to regulate risk. The empirical findings demonstrate that high levels of public concern over these cases do not translate into punitive attitudes. Such cases are viewed rationally and constructively, and lead to instrumental rather than purely expressive enforcement preferences

Global hydrodynamic analysis of the molecular flexibility of galactomannans

In the past, intrinsic viscosity and sedimentation velocity analyses have been used separately to assess the conformation and flexibility of guar and locust bean gum galactomannans based on worm-like chain and semi-flexible coil models. Publication of a new global method combining data sets of both intrinsic viscosity and sedimentation coefficient with molecular weight, and minimising a target (error) function now permits a more robust analysis. Using this approach, values for the persistence length of (10 ± 2) nm for guar and (7 ± 1) nm for locust bean gum are returned if the mass per unit length ML is floated as a variable. Using a fixed mass per unit length based on the known compositional data of each galactomannan yields a similar value for Lp in both cases, (8 ± 1) nm for guar and (9 ± 1) nm for locust bean gum, with combined set of data yielding (9 ± 1) nm: within experimental error the flexibilities of both galactomannans are very similar. © 2007 Elsevier Ltd. All rights reserved

The Shifting Imaginaries of Corporate Crime

This article begins by setting out an analysis of the process of conventionalizing corporate crime that arises from the symbiotic relationship between states and corporations. Noting briefly the empirical characteristics of four broad categories of corporate crime and harm, the article then turns to explore the role of the state in its production and reproduction. We then problematize the role of the state in the reproduction of corporate crime at the level of the global economy, through the “crimes of globalization” and “ecocide,” warning of the tendency in the research literature to oversimplify the role of states and of international organizations. The article finishes by arguing that, as critical academics, it is our role to ensure that corporate crime is never normalized and fully conventionalized in advanced capitalist societies