Comparação da eficácia de tenoxicam administrado por via oral e intra‐articular a pacientes com osteoartrite de joelhos

ResumoJustificativa e objetivosTenoxicam é amplamente usado no tratamento da osteoartrite (OA) e o nosso objetivo foi comparar a eficácia de tenoxicam administrado por via oral (VO) e intra‐articular (IA) no tratamento da OA.MétodosEste estudo foi conduzido entre 2011 e 2012 por meio de análise retrospectiva e comparação dos resultados de 60 pacientes que foram clínica e radiologicamente diagnosticados com OA degenerativa de joelhos na Policlínica de Tratamento da Dor do Hospital Estadual de Bünyan. Os 60 pacientes incluídos no estudo foram alocados em dois grupos. O primeiro grupo (tenoxicam IA, n=30) incluiu resultados de pacientes submetidos à injeção nos joelhos por via IA de 20mg de tenoxicam uma vez por semana durante três semanas e o segundo grupo (tenoxicam VO, n=30) incluiu pacientes que receberam 20mg de tenoxicam por VO uma vez por dia durante três semanas. Todos os pacientes foram avaliados clinicamente na fase basal pré‐tratamento e em uma semana, um mês e três meses pós‐tratamento, de acordo com os critérios especificados.Resultados e conclusõesDos 60 pacientes, 22 eram do sexo masculino e 38 do sexo feminino. Em ambos os grupos, melhorias significativas foram detectadas em todos os parâmetros da escala visual analógica, do índice Western Ontario and MacMaster (Womac – dor, atividade física e rigidez dos joelhos) e do índice de Lequesne nas avaliações feitas em uma semana, um mês e três meses e comparadas aos valores basais. Além disso, uma melhor adesão ao tratamento e tolerabilidade ao sistema gastrointestinal no grupo tenoxicam IA também foram observadas. A administração de tenoxicam IA pode ser considerada como um método opcional de tratamento em pacientes com OA de joelhos que não podem usar tenoxicam por VO, especialmente por causa dos efeitos colaterais sobre o sistema gastrintestinal, e naqueles com dificuldades de adaptação ao tratamento.AbstractBackground and objectivesTenoxicam is widely used in osteoarthritis treatment and we aimed to compare the effectivity of oral and intra‐articular administration of tenoxicam in osteoarthritis treatment.MethodsThis study was performed between 2011 and 2012 by retrospectively analyzing and comparing the findings of 60 patients who were clinically and radiologically diagnosed with knee degenerative osteoarthritis in Bünyan state hospital pain policlinic. 60 patients included in the study were divided into two groups. The first group (tenoxicam IA, n=30) included patient findings of those subjected to intra‐articular injection of 20mg tenoxicam to the knee once a week for three weeks and the second group (oral tenoxicam, n=30) included patients who were administered 20mg oral tenoxicam once a day for three weeks. All patients were clinically evaluated pre‐treatment and in the 1st week, 1st month and 3rd month post‐treatment according to specified criteria.Results and conclusions22 of 60 patients included in the study were male and 38 were female. In both groups significant improvements were detected in all of the observed parameters: visual analog scale, Western Ontario McMaster Osteoarthritis Index (pain, physical activity, knee stiffness) and Lequesne index scores and in the evaluations performed in 1st week, 1st month and 3rd month with respect to pre‐treatment values. Besides, a better compliance to treatment and gastrointestinal system tolerability in tenoxicam IA group was also observed. Intra‐articular tenoxicam administration could be thought as an alternative treatment method in patients with knee osteoarthritis who cannot use oral tenoxicam especially due to systemic gastrointestinal system side effects and those who have difficulties in adapting to treatment

The effects of ozone therapy on extremity ischemia-reperfusion injury in a rabbit model

Introduction: Ischemia is reversible or irreversible cell/tissue damage that is secondary to insufficient blood flow to tissues or organs. Ischemia causes many metabolic and structural changes at the cellular level. Ozone therapy is often used as an antioxidant remedy. This study aimed to investigate the effects of ozone therapy on extremity ischemia-reperfusion (IR) injury. Methods: Twenty-four New Zealand White (NZW) rabbits were randomly allocated into three groups. Each group consisted of eight rabbits. Group I was the control group, Group II was the ischemia group, and Group III, the ozone group.  Femoral arteries of the right legs were dissected, and femoral arterial occlusion was performed in Group II and III.  Hematological and histopathological evaluation was performed in all groups. Results: The levels of total antioxidant status (TAS) after the surgical procedure was higher in the ozone group compared to the ischemia group (p=0.036). In addition, the levels of malondialdehyde (MDA) after the surgical procedure were lower in the ozone group compared to the ischemia group but not statistically significant (p=0.093). The control and ozone groups were histopathologically similar. Conclusions: Ozone therapy may be used as an alternative treatment modality with its anti-inflammatory and antioxidant effects for the treatment of extremity IR injury

Comparison of the effectivity of oral and intra-articular administration of tenoxicam in patients with knee osteoarthritis

ABSTRACTBACKGROUND AND OBJECTIVES:Tenoxicam is widely used in osteoarthritis treatment and we aimedto compare the effectivity of oral and intra-articular administration of tenoxicam in osteoarthri-tis treatment.METHODS: This study was performed between 2011 and 2012 by retrospectively analyzing andcomparing the findings of 60 patients who were clinically and radiologically diagnosed with kneedegenerative osteoarthritis in Bünyan state hospital pain policlinic. 60 patients included in thestudy were divided into two groups. The first group (tenoxicam IA, n = 30) included patientfindings of those subjected to intra-articular injection of 20 mg tenoxicam to the knee oncea week for three weeks and the second group (oral tenoxicam, n = 30) included patients whowere administered 20 mg oral tenoxicam once a day for three weeks. All patients were clini-cally evaluated pre-treatment and in the 1st week, 1st month and 3rd month post-treatmentaccording to specified criteria.RESULTS AND CONCLUSIONS: Twenty two of 60 patients included in the study were male and 38were female. In both groups significant improvements were detected in all of the observedparameters: visual analog scale, Western Ontario McMaster Osteoarthritis Index (pain, physicalactivity, knee stiffness) and Lequesne index scores and in the evaluations performed in 1st week,1st month and 3rd month with respect to pre-treatment values. Besides, a better complianceto treatment and gastrointestinal system tolerability in tenoxicam IA group was also observed.Intra-articular tenoxicam administration could be thought as an alternative treatment methodin patients with knee osteoarthritis who cannot use oral tenoxicam especially due to systemicgastrointestinal system side effects and those who have difficulties in adapting to treatment

Tavşan modelinde ekstremite iskemi-reperfüzyon hasarına ozon tedavisinin etkisi

Introduction: Ischemia is reversible or irreversible cell/tissue damage that is secondary to insufficient blood flow to tissues or organs. Ischemia causes many metabolic and structural changes at the cellular level. Ozone therapy is often used as an antioxidant remedy. This study aimed to investigate the effects of ozone therapy on extremity ischemia-reperfusion (IR) injury. Methods: Twenty-four New Zealand White (NZW) rabbits were randomly allocated into three groups. Each group consisted of eight rabbits. Group I was the control group, Group II was the ischemia group, and Group III, the ozone group.  Femoral arteries of the right legs were dissected, and femoral arterial occlusion was performed in Group II and III.  Hematological and histopathological evaluation was performed in all groups. Results: The levels of total antioxidant status (TAS) after the surgical procedure was higher in the ozone group compared to the ischemia group (p=0.036). In addition, the levels of malondialdehyde (MDA) after the surgical procedure were lower in the ozone group compared to the ischemia group but not statistically significant (p=0.093). The control and ozone groups were histopathologically similar. Conclusions: Ozone therapy may be used as an alternative treatment modality with its anti-inflammatory and antioxidant effects for the treatment of extremity IR injury

Turkish Anaesthesiologist's Experiences of Anaesthetic Management of Patients with Obstructive Sleep Apnea (OSA)

Objective: Obstructive sleep apnea (OSA) is an important health problem that is increasing with the increase in the incidence of obesity. For patients with OSA, it is reported that preoperative OSA diagnosis is made in only 10%-20% of the patients. Therefore, it gains importance that these patients are diagnosed in the preoperative period. The aim of this study is to analyze with a survey the experiences of anaesthesia experts working in Turkey about the diagnosis of patients with OSA, anaesthetic methods and postoperative care

Agenesis of Isthmus of the Thyroid Gland in a Patient with Graves-Basedow Disease and a Solitary Nodule

The thyroid is a vascular endocrine gland with two lateral lobes connected by a narrow, median isthmus. Although a wide range of congenital anomalies of the thyroid gland has been reported in the literature, agenesis of the thyroid isthmus is a very rare congenital anomaly. Thyroid isthmus agenesis does not manifest clinical symptoms, and it can be confused with other thyroid pathologies. We describe a patient with no isthmus of the thyroid, associated with Graves-Basedow disease. Thyroid isthmus agenesis should be kept in mind in order for surgical procedures involving thyroid pathologies to be carried out safely

Use of Succinylcholine by Anaesthetists in Turkey: A National Survey

Objective: Although succinylcholine (SCh) has side effects, it is among the most commonly used muscle relaxants for rapid induction because of the faster onset of its effects and short effect duration. However, there is no information regarding the frequency of use of SCh by anaesthetists in Turkey. This study aims to investigate the use of SCh by anaesthetists working in Turkey