The Grizzly, March 1, 1985

Students Recapture Bear • Road Crews Close Route 29 • Future of Greeks Depends Upon Pledging • Letters: Softball Team Wants Recognition; Inconsiderate Students Annoy Peers; Students Must Grow Up • Springsteen Wins His First Grammy • A Passage to India Deserves a Ten Rating • Van Morrison Comes Back • Profile: Local Man Leads Different Sort of Life • Campus Priest Popular with Students • Men\u27s Track Goes to MAC\u27s • Choir, Orchestra to Perform Handel • Scenes From the Show • Nobel Prize Winner to Speak Tuesday • Fraternity Pledging Underwayhttps://digitalcommons.ursinus.edu/grizzlynews/1135/thumbnail.jp

The Grizzly, February 1, 1985

Ursinus Dodges Enrollment Drought • USGA Candidate Petitions Due • Letter: Spanish Prof Encounters Alumnus • New Fogerty Album a Hit • The Beat Goes Public • pro Theatre • Swimmin\u27 Women Boost Record to 3-2 • Grapplers Win 6, Lose 1 • Injured Matman Won\u27t Quit • Mers and Vers Compete During Break • Men\u27s B-ball Defeat Moravian • Lady Bears Trying to Pull Out of Slump • Chinese Star Talks to Bootershttps://digitalcommons.ursinus.edu/grizzlynews/1131/thumbnail.jp

The Grizzly, October 12, 1984

Students and Administrators Disagree on Effectiveness of Existing Alcohol Policies • Former Economics Chairman Now ACE Fellow • Twisted Sister and the State of Modern Youth Dissidence • News of Yesteryear: War Brings Feminine Touch to Freeland Hall • UC Welcomes Three Foreign Students • Gridders Handle Hopkins • Off-Campus Entertainment: Pulsations! • Shorts: Ferguson Concert; Thurber Carnival; Trivia-thon Scheduled • New Faculty: Math Welcomes Shaw • Some Keystone Factshttps://digitalcommons.ursinus.edu/grizzlynews/1124/thumbnail.jp

The Grizzly, March 2, 1984

Reagan Proposes to Cut Student Aid: 62% Ursinus Students Could Feel Bite • Tray Offenders Discussed • Students Elect New USGA Officers • Writing Seminar Features Alumni • Presidents Corner: Frats Move in Desirable Direction • Letters to the Editor: USGA Concerned With Student Apathy; Get in Gear • Board Elects Two New Members, Appoints Seven • Women\u27s Club Plans Events • WRUC Gets Technician • The Lantern Seeks Contributions • Cogger Heads State Study • Fall Registration Looms on Horizon • Learn While You Work • Sports Profile: Mo Gorman Excels • Basketball Team Wraps Up 83-84 Season • Bears Make Tracks • Grapplers Shine At MACs: Doyle Crowned 150lb Champ; Racich Named Coach of the Year • Doyle and Paolone Successful in MAC Competition • Satisfied with Nationalshttps://digitalcommons.ursinus.edu/grizzlynews/1114/thumbnail.jp

The Grizzly, March 2, 1984

Reagan Proposes to Cut Student Aid: 62% Ursinus Students Could Feel Bite • Tray Offenders Discussed • Students Elect New USGA Officers • Writing Seminar Features Alumni • Presidents Corner: Frats Move in Desirable Direction • Letters to the Editor: USGA Concerned With Student Apathy; Get in Gear • Board Elects Two New Members, Appoints Seven • Women\u27s Club Plans Events • WRUC Gets Technician • The Lantern Seeks Contributions • Cogger Heads State Study • Fall Registration Looms on Horizon • Learn While You Work • Sports Profile: Mo Gorman Excels • Basketball Team Wraps Up 83-84 Season • Bears Make Tracks • Grapplers Shine At MACs: Doyle Crowned 150lb Champ; Racich Named Coach of the Year • Doyle and Paolone Successful in MAC Competition • Satisfied with Nationalshttps://digitalcommons.ursinus.edu/grizzlynews/1114/thumbnail.jp

Regulation der Genexpression von MYCN in humanen Neuoblastomzellen durch Transkriptionsfaktoren der E2F-Familie

Seit fast 30 Jahren ist bekannt, dass die Amplifikation und Expression des Onkogens MYCN in Neuroblastomen mit einer sehr ungünstigen Prognose für die Patienten einhergeht. Dennoch liegen die Mechanismen der Genregulation von MYCN weiterhin größtenteils im Dunkeln. Die Präsenz potentieller Bindungsstellen für E2F-Proteine im Promotor des MYCN-Gens sowie Zellkulturexperimente lieferten Hinweise auf eine Rolle der Transkriptionsfaktoren der E2F-Familie in der Regulation der N-myc-Expression. Ziel dieser Arbeit war die Beantwortung der Frage, ob E2F-Proteine notwendig sind, um eine primär hohe Expression von N-myc in Neuroblastomzellen mit Amplifikation des Onkogens aufrechtzuerhalten, und ob sie hinreichend sind, um die Transkription von MYCN in Zellen ohne endogene Expression von N-myc einzuleiten. Durch Überexpression des Tumorsuppressorproteins p16, welches zu einer Inaktivierung endogener E2F-Proteine führt, konnte die MYCN-mRNA-Menge in Neuroblastomzellen deutlich gesenkt werden. Vergleichbare Resultate wurden durch Expression von dominant negativem E2F-1 erzielt. Da in einigen Studien gezeigt werden konnte, dass Myc-Proteine ihrerseits E2F-Gene aktivieren können, nehmen wir an, in aggressiven Neuroblastomen könnte eine positive Rückkopplungsschleife zwischen E2F-Transkriptionsfaktoren auf der einen und N-myc auf der anderen Seite existieren, die die gesteigerte Aktivität des MYCN-Onkogens aufrechterhält. Stabil transfizierte E2F-ER-Fusionsproteine waren jedoch nicht in der Lage, das endogene MYCN-Gen in Neuroblastomzellen ohne Expression von N-myc anzuschalten. E2F-Proteine werden folglich für das volle Ausmaß der starken Expression von N-myc in Neuroblastomen benötigt, sind aber nicht ausreichend, um das Onkogen MYCN in Zellen ohne endogenes N-myc zu aktivieren. In der Zukunft könnte durch Verhinderung der Bindung von E2F-Proteinen an den MYCN-Promotor oder durch gentherapeutische Ansätze, die z.B. mittels viraler Infektion den Signalweg zwischen p16 und E2F rekonstruieren, die Expression von N-myc in Neuroblastomen gesenkt werden, so dass die Aggressivität der Tumore reduziert und die individuelle Prognose der Patienten verbessert werden könnte

The wave energy converter control competition (WECCCOMP): Wave energy control algorithms compared in both simulation and tank testing

The wave energy control competition established a benchmark problem which was offered as an open challenge to the wave energy system control community. The competition had two stages: In the first stage, competitors used a standard wave energy simulation platform (WEC-Sim) to evaluate their controllers while, in the second stage, competitors were invited to test their controllers in a real-time implementation on a prototype system in a wave tank. The performance function used was based on converted energy across a range of standard sea states, but also included aspects related to economic performance, such as peak/average power, peak force, etc. This paper compares simulated and experimental results and, in particular, examines if the results obtained in a linear system simulation are borne out in reality. Overall, within the scope of the device tested, the range of sea states employed, and the performance metric used, the conclusion is that high-performance WEC controllers work well in practice, with good carry-over from simulation to experimentation. However, the availability of a good WEC mathematical model is deemed to be crucial

The Grizzly, September 14, 1984

Record Number Enter Ursinus • Town Hears College Plans • An Athlete\u27s Battle With Alcohol • News of Yesteryear • Ursinus Enters New Era of Communications • Cobbs Shows Enthusiasm for New Position • New Dean Coaches R.A.\u27s • English Moves Into New Offices • Smooth Sailing for Hockey....on a Bumpy Field • UC Soccer Wins Home Opener • Gridders Look to Be Winners • Cross Country Kicks Off \u2784 Season • Discover Philadelphia • McQuellan Leaves • Calendarhttps://digitalcommons.ursinus.edu/grizzlynews/1120/thumbnail.jp