Teaching materiality and religion: experience and products

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The Grizzly, February 9, 1993

Novelist Reed to Satire P.C. • New Twists on Pledging • Quilt Weaves Its Way to Ursinus • Doctor Fletcher, UC Professor Emeritus, Hospitalized • Airband is Coming • Coffee House Counts on a Big Semester • Senior Profile: Lynn Cunnane • Fox\u27s Latest Teensomething • A Degree is not Enough Today • The Absurdity of the Circular Argument • U.C. Gets Bad P.R.https://digitalcommons.ursinus.edu/grizzlynews/1309/thumbnail.jp

Mutations to the histone H3 αN region selectively alter the outcome of ATP-dependent nucleosome-remodelling reactions

Mutational analysis of the histone H3 N-terminal region has shown it to play an important role both in chromatin function in vivo and nucleosome dynamics in vitro. Here we use a library of mutations in the H3 N-terminal region to investigate the contribution of this region to the action of the ATP-dependent remodelling enzymes Chd1, RSC and SWI/SNF. All of the enzymes were affected differently by the mutations with Chd1 being affected the least and RSC being most sensitive. In addition to affecting the rate of remodelling by RSC, some mutations prevented RSC from moving nucleosomes to locations in which DNA was unravelled. These observations illustrate that the mechanisms by which different ATP-dependent remodelling enzymes act are sensitive to different features of nucleosome structure. They also show how alterations to histones can affect the products generated as a result of ATP-dependent remodelling reactions

The Grizzly, March 1, 1994

Up \u27Til Noone to Play at The Trappe • Last Semester\u27s Blood Drive a Success • Kane Encourages Support for Blood Drive • CIA Officer and his Wife Accused of Spying • Professor Profile: Keith Brand • Broughton Exhibit to Open in Berman • Senior Profile: Alan McCabe • The Snow Closing Debates, Continued • Letter to the Editor • To All Administrators, Faculty, Staff, and Other Interested Parties • Women\u27s Hoops Have Best Season Everhttps://digitalcommons.ursinus.edu/grizzlynews/1332/thumbnail.jp

The Grizzly, December 8, 1992

Gomez Speaks on Gildah Stories • Wellness Center Confusion • Greek Service Projects • How To Handle Holiday Dysfunction • Senior Profile: Tina Moukoulis • Wismer\u27s Christmas Dinner • Russian Rock With Yuri • Exam Schedule • Standards • A Lack of Preventive Aid • Letters: Greetings from France; Response to Disabled Accessibility • UC Snaps Losing Steak; Picks Up Three Wins • Lady Bears Recaphttps://digitalcommons.ursinus.edu/grizzlynews/1307/thumbnail.jp

The Grizzly, April 19, 1994

Erdrich Speaks of Cultural Struggles • Friendly Fire Over Iraq • Greeks Participate in Greek Week • U.S.G.A. Responds to Requests for a Wismer Meal Plan • Tropical Conservationist to Speak at Ursinus • President John Bartholomew Speaks Again • Tuning in to Talk Radio • Bands to Perform Saturday • It\u27s Not a Matter of Dryness • Women\u27s Lacrosse Crushes Swarthmore; Falls to Johns Hopkins • Eagles Draft Preview • George White Named New Men\u27s Basketball Coach at Ursinushttps://digitalcommons.ursinus.edu/grizzlynews/1336/thumbnail.jp

The Grizzly, February 22, 1994

Breaking Down the Barriers: One Man\u27s Struggle with Homosexuality, Stereotypes and the Military • Maintenance Man, Humanitarian • Pledging Private Eyes • Pledging Underway Once Again • Olympic Update • Are There Really any Losers in the Olympics? • Ursinus Students Raise Money for a Friend in Need • And When the Sawdust Cleared...It Was a Masterpiece • Come out and Support a U.C. Senior • Restaurant Night Revisited • Senior Spotlight: Joshua Donald Carter • Clinton: King of Astro Turf • Learn by Listening to Yourself • Sports Picture Page: The Two Hottest Teams Around • Baseball Preview \u2794 • Lady Bears are Eastern Division Champshttps://digitalcommons.ursinus.edu/grizzlynews/1331/thumbnail.jp

The Grizzly, February 2, 1993

Cowboys Tame Buffalo, 52-17 • Upsilon Phi Delta Approved • AIDS Quilt • Al Eaton\u27s We Are the Dream • Day For a King • Power Plays • Bernie Bernie Headflap Wins Battle of the Bands • Lorelei at Chateau Granieri • Ice Skating Fun • The Case of the Disappearing Sevs (Or: Why Collegeville\u27s Most Famous Convenient Mart Upped & Left) • Senior Profile: Chris Kakacek • The New Zack\u27s: Why Hike to WaWa? • What\u27s Up in Wellness • Character was an Issue, Again • The Importance of Effort and A Dream • UC Baseball Preview \u2793 • Gymnasts Hoping For Powerful Season • Lady Bears Make Playoffs • Swimmers Working Hard • Football Awards Banquet Held • Wrestlers Continue Excellence • Men\u27s Basketball Split Twohttps://digitalcommons.ursinus.edu/grizzlynews/1308/thumbnail.jp

The Grizzly, November 17, 1992

Ann Landers at Founder\u27s Day • Dr. Clayton Speaks on Education • An Active MSU • Elliot Speaks on Racism • Dinosaurs and Meteors • What Wismer Can Do For You • Greeks Grow With Chi Rho Psi • Top Ten Reasons Ursinus Needs a Coffeehouse • Catch of the Week • Shoulder Dancing to Depeche Mode • Voyages to Freedom Exhibit and the Jewish Experience in America • Messiah • In Their Own Words • Let\u27s See How They Like It • Concert and Jazz Bands to Perform • A Push for Physically Challenged Accessibility • Who\u27s on First? • Letters to the Editor • The Editorial Mission: Our Relationship to The Grizzly • UC Men\u27s Basketball For \u2792-\u2793 • Senior Billitto Glad He Transferred to UC • Field Hockey \u2792: A Look Back • Football Ends Tough Yearhttps://digitalcommons.ursinus.edu/grizzlynews/1305/thumbnail.jp

B-cell Zone Reticular Cell Microenvironments Shape CXCL13 Gradient Formation

Through the formation of concentration gradients, morphogens drive graded responses to extracellular signals, thereby fine-tuning cell behaviors in complex tissues. Here we show that the chemokine CXCL13 forms both soluble and immobilized gradients. Specifically, CXCL13+ follicular reticular cells form a small-world network of guidance structures, with computer simulations and optimization analysis predicting that immobilized gradients created by this network promote B-cell trafficking. Consistent with this prediction, imaging analysis show that CXCL13 binds to extracellular matrix components in situ, constraining its diffusion. CXCL13 solubilization requires the protease cathepsin B that cleaves CXCL13 into a stable product. Mice lacking cathepsin B display aberrant follicular architecture, a phenotype associated with effective B cell homing to but not within lymph nodes. Our data thus suggest that reticular cells of the B cell zone generate microenvironments that shape both immobilized and soluble CXCL13 gradient