Correcting the Bias in the Concentration Index when Income is Grouped

The problem introduced by grouping income data when measuring socioeconomic inequalities in health (and health care) has been highlighted in a recent study. We reexamine this issue and show there is a tendency to underestimate the concentration index at an increasing rate when lowering the number of income categories. This bias results from a form of measurement error and we propose two correction methods. Firstly, the use of instrumental variables (IV) can reduce the error within income categories. Secondly, through a simple formula for correction that is based only on the number of groups. We compare the performance of these methods using data from 15 European countries and the United States. We find that the simple correction formula reduces the impact of grouping and always outperforms the IV approach. Use of this correction can substantially improve comparisons of the concentration index both across countries and across time.concentration index; errors-in-variables; instrumental variables; categorical data; first-order correction

Algorithms and Architecture for Real-time Recommendations at News UK

Recommendation systems are recognised as being hugely important in industry, and the area is now well understood. At News UK, there is a requirement to be able to quickly generate recommendations for users on news items as they are published. However, little has been published about systems that can generate recommendations in response to changes in recommendable items and user behaviour in a very short space of time. In this paper we describe a new algorithm for updating collaborative filtering models incrementally, and demonstrate its effectiveness on clickstream data from The Times. We also describe the architecture that allows recommendations to be generated on the fly, and how we have made each component scalable. The system is currently being used in production at News UK.Comment: Accepted for presentation at AI-2017 Thirty-seventh SGAI International Conference on Artificial Intelligence. Cambridge, England 12-14 December 201

Not Just a Cookbook - L\u27Ecrivain Restaurant

Published by L\u27Ecrivain Restaurant, 109A Lower Baggot Street, Dublin 2, Ireland in 2004. Photography by Mike O\u27Toole, Foreword by Hugh Leonard. Recipe testers Anne Marie Tobin, Lucy O\u27Grady. Editing & indexing, Pat Carroll. Printed and bound in Belgium by Snoeck-Ducaju & Zoom. 236 p. col. ill. 27 cmhttps://arrow.tudublin.ie/irckbooks/1082/thumbnail.jp

Estimating structural mean models with multiple instrumental variables using the generalised method of moments

Instrumental variables analysis using genetic markers as instruments is now a widely used technique in epidemiology and biostatistics. As single markers tend to explain only a small proportion of phenotypical variation, there is increasing interest in using multiple genetic markers to obtain more precise estimates of causal parameters. Structural mean models (SMMs) are semi-parametric models that use instrumental variables to identify causal parameters, but there has been little work on using these models with multiple instruments, particularly for multiplicative and logistic SMMs. In this paper, we show how additive, multiplicative and logistic SMMs with multiple discrete instrumental variables can be estimated efficiently using the generalised method of moments (GMM) estimator, how the Hansen J-test can be used to test for model mis-specification, and how standard GMM software routines can be used to fit SMMs. We further show that multiplicative SMMs, like the additive SMM, identify a weighted average of local causal effects if selection is monotonic. We use these methods to reanalyse a study of the relationship between adiposity and hypertension using SMMs with two genetic markers as instruments for adiposity. We find strong effects of adiposity on hypertension, but no evidence of unobserved confounding.

Estimating Structural Mean Models with Multiple Instrumental Variables using the Generalised Method of Moments

Instrumental variables analysis using genetic markers as instruments is now a widely used technique in epidemiology and biostatistics. As single markers tend to explain only a small proportion of phenotypical variation, there is increasing interest in using multiple genetic markers to obtain more precise estimates of causal parameters. Structural mean models (SMMs) are semi-parametric models that use instrumental variables to identify causal parameters, but there has been little work on using these models with multiple instruments, particularly for multiplicative and logistic SMMs. In this paper, we show how additive, multiplicative and logistic SMMs with multiple discrete instrumental variables can be estimated efficiently using the generalised method of moments (GMM) estimator, how the Hansen J-test can be used to test for model mis-specification, and how standard GMM software routines can be used to fit SMMs. We further show that multiplicative SMMs, like the additive SMM, identify a weighted average of local causal effects if selection is monotonic. We use these methods to reanalyse a study of the relationship between adiposity and hypertension using SMMs with two genetic markers as instruments for adiposity. We find strong effects of adiposity on hypertension, but no evidence of unobserved confounding.Structural Mean Models, Multiple Instrumental Variables, Generalised Method of Moments, Mendelian Randomisation, Local Average Treatment Effects

The crystal structure of a biological insulated transmembrane molecular wire

A growing number of bacteria are recognized to conduct electrons across their cell envelope, and yet molecular details of the mechanisms supporting this process remain unknown. Here, we report the atomic structure of an outer membrane spanning protein complex, MtrAB, that is representative of a protein family known to transport electrons between the interior and exterior environments of phylogenetically and metabolically diverse microorganisms. The structure is revealed as a naturally insulated biomolecular wire possessing a 10-heme cytochrome, MtrA, insulated from the membrane lipidic environment by embedding within a 26 strand β-barrel formed by MtrB. MtrAB forms an intimate connection with an extracellular 10-heme cytochrome, MtrC, which presents its hemes across a large surface area for electrical contact with extracellular redox partners, including transition metals and electrodes