Match-play, training workloads and sensorimotor and neuromuscular performance of elite young soccer players

Nigel Gleeson - ORCID: 0000-0003-0072-1521 https://orcid.org/0000-0003-0072-1521Purpose: The purpose of this study was to assess sensorimotor and neuromuscular performance capabilities over an in-season microcycle in early-career professional soccer players and to examine the relationship with training and match-play workload. Methods: Sensorimotor and neuromuscular performance capabilities (isometric knee extensor: force replication error, peak force, electromechanical delay, rate of force development) of 12 professional soccer players were assessed over a 7-day period. Training and match-play workload was also recorded over the same period for each player (high-intensity running distance). Fluctuations in sensorimotor and neuromuscular performance and workload variables were analysed. Results: There was evidence of fluctuations in sensorimotor and neuromuscular performance capability over the microcycle that reached statistical (p < .005) and practical (18.1% [baseline-to-peak]) significance alongside heterogeneity in training and match workload (264% [coefficient of variation], p < .0005). Some temporal congruence among fluctuating patterns of intra-microcycle training and match-play load and concomitant electromechanical delay performance was noted (p < .005). Asynchronous responses were observed for peak force, but rate of force development and force replication error capabilities were unchanged during the microcycle. Conclusion: While some neuromuscular performance capabilities fluctuate over an in-season microcycle and are influenced partially by high-intensity running workload, sensorimotor performance capabilities were unchanged during the microcycle.https://doi.org/10.55860/RIIE10933pubpub

Differential regulation of STA genes of Saccharomyces cerevisiae

The single glucoamylase gene ( SGA 1) of the yeast Saccharomyces cerevisiae is expressed exclusively during the sporulation phase of the life cycle. Enzymatic studies and nucleic acid sequence comparisons have shown that the SGA 1 glucoamylase is closely related to the secreted enzymes of S. cerevisiae var. diastaticus . The latter are encoded by any of three unlinked STA genes, which have been proposed to derive from the ancestral SGA 1 form by genomic rearrangement. We show that the regulation of SGA 1 is distinct from that of the other members of the STA gene family. SGA 1 expression did not respond to STA 10, the primary determinant of glucoamylase expression from STA 2. Unlike STA 2, SGA 1 was not regulated directly by the mating type locus. Expression of SGA1 depended on the function of the MAT products in supporting sporulation and not on the formation of haploid progeny spores or on the composition of the mating type locus per se. We conclude that the STA genes acquired regulation by STA 10 and MAT by the genomic rearrangements that led to their formation. This regulation is thus distinct from that of the ancestral SGA 1 gene.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47571/1/438_2004_Article_BF00283028.pd

Implementation of a Quit Smoking Programme in Community Adult Mental Health Services–A Qualitative Study

Little is known about the experiences of people with severe mental health difficulties in smoking cessation interventions. This study aimed to review the implementation of a smoking cessation programme across 16 community mental health day services. The aim was to establish the experience from both service user and facilitator perspectives and refine implementation for future groups. In-depth interviews were conducted with 20 service users and four focus groups held with 17 facilitators. Thematic analysis was used to analyse the data for emergent themes in relation to key enablers and barriers to implementation. Data from service users and facilitators revealed that implementation was enabled by an open and engaged recruitment approach; the resourcefulness of facilitators; programme materials and group-based format; combining the cessation programme with other and broader health initiatives; and participants\u27 motivations, including health and money. Barriers included the structure of the service; the lack of a joined-up approach across the health services; literacy issues and the serial/logical process assumed by the programme. Barriers perceived as more specific to those with mental health difficulties included the use of smoking as a coping mechanism, lack of alternative activities/structure and lack of consistent determination. The tobacco free policy, implemented shortly before the programme, interestingly emerged as both a barrier and an enabler. In conclusion, although this group-based cessation programme in community mental health settings was well-received overall, a number of key barriers persist. A joined-up approach which addresses the culture of smoking in mental health settings, inconsistencies in smoking policies, and provides consistent cessation support, is needed. Care needs to be taken with the timing as overall it may not be helpful to introduce a new smoking cessation programme at the same time as a tobacco free policy

Biomarkers for cystic fibrosis drug development

To provide a review of the status of biomarkers in cystic fibrosis drug development, including regulatory definitions and considerations, a summary of biomarkers in current use with supportive data, current gaps, and future needs

Disorder Induced Power-law Gaps in an Insulator-metal Mott Transition

A correlated material in the vicinity of an insulator-metal transition (IMT) exhibits rich phenomenology and variety of interesting phases. A common avenue to induce IMTs in Mott insulators is doping, which inevitably leads to disorder. While disorder is well known to create electronic inhomogeneity, recent theoretical studies have indicated that it may play an unexpected and much more profound role in controlling the properties of Mott systems. Theory predicts that disorder might play a role in driving a Mott insulator across an IMT, with the emergent metallic state hosting a power law suppression of the density of states (with exponent close to 1; V-shaped gap) centered at the Fermi energy. Such V-shaped gaps have been observed in Mott systems but their origins are as yet unknown. To investigate this, we use scanning tunneling microscopy and spectroscopy to study isovalent Ru substitutions in Sr3(Ir1-xRux)2O7 (0≤x≤0.5) which drives the system into an antiferromagnetic, metallic state. Our experiments reveal that many core features of the IMT such as power law density of states, pinning of the Fermi energy with increasing disorder, and persistence of antiferromagnetism can be understood as universal features of a disordered Mott system near an IMT and suggest that V-shaped gaps may be an inevitable consequence of disorder in doped Mott insulators

24th Annual Richard A. Harrison Symposium: A Celebration of Student Research and Achievement in the Humanities and Social Sciences

The Harrison Symposium celebrates independent and collaborative student research in the Social Sciences and Humanities. The Harrison is usually held as an annual conference in May, but this year’s shift to remote teaching and the new coronavirus pandemic eliminated the opportunity for in-person presentations. Instead of cancelling the event, students nominated by faculty members were invited either to participate in next year’s Harrison, or to contribute to the volume you are now reading. Reimagining the Harrison as a written artifact was inspired by the 1997 Harrison Symposium. In the early years of the conference, the Dean of Faculty Richard A. Harrison (1991-1997) published the proceedings of the symposium – formerly known as the Humanities and Social Sciences Symposium though the event was later renamed in Harrison’s honor – as a collection of papers. Margaret E. Madden, then Associate Dean of the Faculty, notes in the introduction to the 1998 proceedings that “Faculty members and departments on campus who received the first symposium collection were pleased to have some visible record of the high level of accomplishments of humanities and social science students, whose products are often not as visible as those students of the performing arts or sciences.” I hope that this version of the Harrison will also serve as a way to publicly and communally celebrate the wide-ranging and incisive research undertaken by students at Lawrence

Relationship Between Venules and Perivascular Spaces in Sporadic Small Vessel Diseases

Background and Purpose— Perivascular spaces (PVS) around venules may help drain interstitial fluid from the brain. We examined relationships between suspected venules and PVS visible on brain magnetic resonance imaging. Methods— We developed a visual venular quantification method to examine the spatial relationship between venules and PVS. We recruited patients with lacunar stroke or minor nondisabling ischemic stroke and performed brain magnetic resonance imaging and retinal imaging. We quantified venules on gradient echo or susceptibility-weighted imaging and PVS on T2-weighted magnetic resonance imaging in the centrum semiovale and then determined overlap between venules and PVS. We assessed associations between venular count and patient demographic characteristics, vascular risk factors, small vessel disease features, retinal vessels, and venous sinus pulsatility. Results— Among 67 patients (69% men, 69.0±9.8 years), only 4.6% (range, 0%–18%) of venules overlapped with PVS. Total venular count increased with total centrum semiovale PVS count in 55 patients after accounting for venule-PVS overlap (β=0.468 [95% CI, 0.187–0.750]) and transverse sinus pulsatility (β=0.547 [95% CI, 0.309–0.786]) and adjusting for age, sex, and systolic blood pressure. Conclusions— Despite increases in both visible PVS and suspected venules, we found minimal spatial overlap between them in patients with sporadic small vessel disease, suggesting that most magnetic resonance imaging-visible centrum semiovale PVS are periarteriolar rather than perivenular

Our friend in the north: the origins, evolution and appeal of the cult of St Duthac of Tain in later Middle Ages

St Duthac of Tain was one of the most popular Scottish saints of the later middle ages. From the late fourteenth century until the reformation devotion to Duthac outstripped that of Andrew, Columba, Margaret and Mungo, and Duthac's shrine in Easter Ross became a regular haunt of James IV (1488-1513) and James V (1513-42). Hitherto historians have tacitly accepted the view of David McRoberts that Duthac was one of several local saints whose emergence and popularity in the fifteenth century was part of a wider self-consciously nationalist trend in Scottish religious practice. This study looks beyond the paradigm of nationalism to trace and explain the popularity of St Duthac from the shadowy origins of the cult to its heyday in the early sixteenth century