10 research outputs found
The effects of perioperative oral management on perioperative serum albumin levels in patients treated surgically under general anesthesia : A multicenter retrospective analysis in Japan
The purpose of the present study was to investigate the efficacy of perioperative oral managements (POMs) on perioperative nutritional conditions in patients undergoing surgery with general anesthesia. Medical records were retrospectively reviewed and the effects of POMs were investigated based on a large number of cases using a multicenter analysis. The profile of serum albumin levels was assessed and compared between patients with and without POMs using the multivariate analysis. Seventeen Eleven thousand and one hundred sixty patients (4,873 males and 6,287 females) were reviewed. Of these, 2710 patients (24.3%) had undergone POMs. The results of a multivariate analysis revealed the significant positive effect of POMs on perioperative serum albumin level (change between at admission and discharge, (Estimate: 0.022, standard error: 0.012, P < .0001). Patient gender, age, surgical site, performance status, the American Society of Anesthesiologists (ASA) physical status classification, operation time, amount of blood loss, and serum albumin level at admission were also significant predictors. Adjusted multivariate analysis of the effects of POMs on perioperative change of serum albumin level in all subjects reveled the significance of POMs intervention (estimate: 0.022, standard error: 0.012, P < .0001). These results suggest that POMs exerts significant positive effects on perioperative serum albumin levels in patients underwent surgery under general anesthesia
EGFR Inhibitor Enhances Cisplatin Sensitivity of Oral Squamous Cell Carcinoma Cell Lines
Epidermal growth factor receptor (EGFR) is involved in multiple aspects of cancer cell biology. EGFR has already been identified as an important target for cancer therapy, with various kinds of EGFR inhibitors currently used in treatment of several human cancers. Recently, EGFR and its downstream signaling pathways were identified as being associated with cisplatin sensitivity. In addition, EGFR inhibitors have shown significant promise for patients who failed cisplatin-based therapy. In this study, we investigated whether treatment with an EGFR inhibitor improves cisplatin sensitivity in oral squamous cell carcinoma (OSCC) cell lines. The effects of a combination of AG1478, a specific EGFR tyrosine kinase inhibitor, with cisplatin were evaluated in cultured OSCC cell lines and cisplatin-resistant sublines. Higher expression of EGFR and p-EGFR was found in the two cisplatin-resistant cell lines compared with the corresponding parental cell lines. In addition, augmented inhibition of OSCC cell growth by the combination of AG1478 with cisplatin was found in both cell lines. These results suggest that the combination of an EGFR inhibitor and cisplatin may be useful as a rational strategy for the treatment of patients with oral cancer with acquired cisplatin resistance
Recovery of Impaired Somatosensory Evoked Fields after Improvement of Tongue Sensory Deficits with Neurosurgical Reconstruction
Somatosensory evoked fields (SEFs) induced by tongue stimulation can be useful as an objective parameter to assess sensory disturbances in the tongue. However, whether tongue SEFs can be useful as a clinical, objective follow-up assessment method of tongue sensation following oral surgery is unknown. Here we describe two cases in which tongue SEFs were successfully used in clinical assessment. Two patients with unilateral tongue sensory deficits caused by lingual nerve injury during lower third molar extraction were recruited. Both patients underwent surgery to repair the damaged nerve, and all tongue sensory evaluations were made once before and once after surgery. SEFs were recorded by stimulating the affected and unaffected sides of the tongue separately, and cortical activity was evaluated over the contralateral hemisphere. The unilaterality of the deficit was also assessed. In both patients, stimulation of the unaffected side evoked reproducible cortical responses pre- and post-surgery. Both patients also recovered some sensation following surgery, as pre-surgery stimulation of the affected side failed to evoke cortical activity, whereas post-surgery stimulation evoked cortical activity on both sides. Sensation was initially highly lateralized in both patients, but was restored to approximately normal in the post-surgery evaluation. Finally, both patientsâ rated their subjective tongue sensations on the affected side over 50% better after the surgical intervention. These cases indicate that tongue SEFs may have a clinical use as an objective parameter for assessing the course of tongue sensory recovery
Application of Tinelâs test combed with clinical neurosensory test distinguishes spontaneous healing of lingual nerve neuropathy after mandibular third molar extraction
Abstract Background Extraction of the mandibular third molar, the most frequent and important surgical procedure in the clinical practice of oral surgery, is associated with the risk of injury of the lingual nerve. Neuropathy of the lingual nerve poses diagnostic challenges regarding the transient or permanent nature of the injury. No consensus or criteria have been established regarding the diagnosis of lingual nerve neuropathy. We applied both Tinelâs test and clinical neurosensory testing together, which can be easily used at the bedside in the early stages of injury. Therefore, we propose a new method to differentiate between lesions with the ability to heal spontaneously and those that cannot heal without surgery. Results Thirty-three patients (29 women, 4 men; mean age, 35.5 years) were included in this study. For all patients, the median interval between nerve injury and initial examination was 1.6 months and that between nerve injury and the second examination before determining the need for surgical management was 4.5 months. The patients were assigned to either group A or B. The spontaneous healing group (group A, nâ=â10) revealed a tendency for recovery within 6 months after tooth extraction. In this group, although there were individual differences in the degree of recovery, a remarkable tendency for recovery was observed based on clinical neurosensory testing in all cases. None of the patients were diagnosed with allodynia. In seven cases, the Tinel test result was negative at the first inspection, and in three cases, the result changed to negative at the second inspection. Conversely, in group B(nâ=â23), no recovery trend was observed with regard to clinical neurosensory testing, and nine patients had allodynia. Further, the Tinel test result was positive for all patients in both examinations. Conclusions Our findings indicate that in case of transient lingual nerve paralysis, clinical neurosensory testing findings deteriorate immediately after tooth extraction and gradually recover, while Tinelâs test shows a negative result. Using Tinelâs test and clinical neurosensory testing together enabled early and easy identification of the severity of the lingual nerve disorder and of lesions that would heal spontaneously without surgical management
Recovery of Impaired Somatosensory Evoked Fields after Improvement of Tongue Sensory Deficits with Neurosurgical Reconstruction
Expression of ADAMTS-5 in deformed human temporomandibular joint discs
Objective: To study the expression of a
disintegrin and metalloproteinase with thrombospondin
motifs 5 (ADAMTS-5) in tissue samples of deformed
human temporomandibular joint (TMJ) discs and cells
obtained from the discs. Materials and methods: Eleven
adult human TMJ discs (nine diseased discs and two
normal discs) were used in this study. The nine diseased
discs were obtained from nine patients with internal
derangement (ID) and osteoarthritis (OA) in the TMJ.
These patients all had anteriorly displaced discs and
deformed mandibular condyles, making conservative
therapy impossible. The tissues were immunohistochemically
stained using ADAMTS-5 antibodies. In
addition, an articular disc cell line from one case was
established by collagenase treatment. The subcultured
cells under both normal and hypoxic conditions (O2:
2%) were incubated for 3, 6, 12 and 24 h after addition
of interleukin-1Ă (IL-1Ă) (1 ng/mL). Subsequently, the
expression of ADAMTS-5 was examined using reverse
transcription-polymerase chain reaction (RT-PCR).
Results: The control group showed negative reactions on
immunohistochemical staining. The discs extracted from
cases with ID and OA presented positive reactions for
ADAMTS-5. The expression of ADAMTS-5 mRNA
increased under both normoxia and hypoxia with the
addition of IL-1Ă, and the peak was observed after 3 h.
Conclusion: These results suggest that ADAMTS-5 is
related to deformation and destruction of human TMJ
discs affected by ID and OA