Nazende’nin sergüzeşti

İhsan'ın İleri'de tefrika edilen Nazende’nin Sergüzeşti adlı roman

Diagnostic Performance: A Comparative Study of the Leukocyte Differential Count on Four Automated Haematology Analysers

Peer Reviewe

Choosing wisely: la lista del gruppo di studio Endocrinologia e Malattie del Metabolismo della Società Italiana di Patologia Clinica e Medicina di Laboratorio

Background.: The need to promote the appropriateness of diagnostic and therapeutic procedures increased in the recent years in the world and in Italy. Scientific societies participated from the beginning in defining modes and tools to support the members in the “translation” of this need in the clinical practice, for example defining lists of the diagnostic and therapeutic procedures with the highest risk of inappropriateness. The most relevant projects at international and national levels were, respectively, Choosing wisely e Slow Medicine. SIPMeL is supporting Slow Medicine and presented at 2015 SIPMel National Congress the list of the 5 procedures with the highest risk of inappropriateness in Laboratory Medicine. Methods.: In 2015 a survey has been carried out among the members of the Group of study Endocrinology-Metabolic diseases that were asked to vote (score 1–10) the five procedures with the highest risk of inappropriateness supporting their score with a short comment and essential references. Results.: The final list was obtained from the sum of the scores and includes: (1) optimal assessment of thyroid function; (2) optimal diagnostics of Cushing syndrome; (3) optimal diagnostics of pheocromocytoma; (4) optimal diagnostics for autoimmune thyroid disease; (5) assessment of 25 (OH) vitamin D. Conclusions.: The top five procedures have been presented at 2015 SIPMel National Congress and will be available in the Society website. We propose that also the other SIPMel groups of study prepare similar list and make them available within the Society and profession in a similar way

Laboratory diagnostics of adrenal diseases. Practice guidelines for pheochromocytoma and paraganglioma [La diagnostica di laboratorio delle malattie del surrene. Raccomandazioni pratiche per feocromocitoma e paraganglioma]

Pheochromocytoma is a catecholamine-producing neuroendocrine tumor derived from the neural crest. It is a rare tumor with an incidence in the general population of 2\u20138 cases per million population per year. Pheochromocytomas most commonly arise in the adrenal medulla but they can also occur extra-adrenally; these tumors are referred to as paragangliomas. The clinical presentation involves a constellation of signs and symptoms associated with catecholamine excess: hypertension (paroxysmal or sustained), sweating, pallor, headaches, palpitations, anxiety, dyspeptic complaints, paresthesias, visual disturbances, chest and abdominal pain

[Colorectal cancer: diagnostic paths on the basis of international guidelines] Tumore del colon retto: percorsi diagnostici sulla base di linee guida internazionali

The colorectal cancer (CCR) is still one of the most important neoplastic pathologies whose mortality and metastatic progression is strictly connected to the structural and biological characteristics of the primary tumor. Compared with an overall increase in incidence, there has been a reduction in mortality by almost 35 percent in the last two decades. These features are undoubtedly due to the significant progress of predictive and preventative medicine that employs several new diagnostic tools and surgical exploration devices (i.e. endoscopy) allowing earlier diagnosis and intervention on patient injuries; in this way, the neoplastic transformation of dysplastic and polyposis lesions and invasiveness of the tumoral mass can be prevent. In particular, the review describes the progress achieved in the screening population programs. Of considerable importance is fecal occult blood test (SOF) survey, which allows the identification of areas of minimal bleeding in the gastroenteric district, hiding a putative neoplastic process. SOF has been highly successful in recent times and has allowed, in Regions where the screening process is applied, to significantly reduce the risk of metastatic disease and the associated mortality rate. Another important forward step is the use of new molecular techniques that allow to analyze mutations and epigenetic lesions of genes involved in the pathogenic mechanism of tumor induction (fecal DNA analyses) as a high sensitivity and specificity instrument for the detection of micro-cracks cancer. Is also discussed, according to the evidence-based medicine principles, the role played by serological markers like CEA and Ca 19.9 which represent prediction and prognostic values in the follow-up and monitoring of the therapeutic success