Evolutionary consequences of behavioral diversity

Iterated games provide a framework to describe social interactions among groups of individuals. Recent work stimulated by the discovery of "zero-determinant" strategies has rapidly expanded our ability to analyze such interactions. This body of work has primarily focused on games in which players face a simple binary choice, to "cooperate" or "defect". Real individuals, however, often exhibit behavioral diversity, varying their input to a social interaction both qualitatively and quantitatively. Here we explore how access to a greater diversity of behavioral choices impacts the evolution of social dynamics in finite populations. We show that, in public goods games, some two-choice strategies can nonetheless resist invasion by all possible multi-choice invaders, even while engaging in relatively little punishment. We also show that access to greater behavioral choice results in more "rugged " fitness landscapes, with populations able to stabilize cooperation at multiple levels of investment, such that choice facilitates cooperation when returns on investments are low, but hinders cooperation when returns on investments are high. Finally, we analyze iterated rock-paper-scissors games, whose non-transitive payoff structure means unilateral control is difficult and zero-determinant strategies do not exist in general. Despite this, we find that a large portion of multi-choice strategies can invade and resist invasion by strategies that lack behavioral diversity -- so that even well-mixed populations will tend to evolve behavioral diversity.Comment: 26 pages, 4 figure

Reduction in size and unsteadiness of a VTOL ground vortex by ground fences

A ground vortex, produced when a jet impinges on the ground in the presence of cross flow, is encountered by V/STOL aircraft hovering near the ground and is known to be hazardous to the aircraft. The objective of this research was to identify a ground-based technique by which both the mean size and fluctuation in size of the ground vortex could be reduced. A simple passive method was identified and examined in the laboratory. Specifically, one or two fine wire mesh screens (ground fences) bent in a horseshoe shape and located on the ground in front of the jet impingement point proved to be very effective. The ground fences work by decreasing the momentum of the upstream-traveling wall jet, effectively causing a higher freestream-to-jet velocity ratio (V(sub infinity)/V(sub j)) and thus, a ground vortex smaller in size and unsteadiness. At(V(sub infinity)/V(sub j)) = 0.15, the addition of a single ground fence resulted in a 70 percent reduction in mean size of the ground vortex. With two ground fences, the mean size decreased by about 85 percent. Fluctuations in size decreased nearly in proportion to the mean size, for both the single and double fence configurations. These results were consistent over a wide range of jet Reynolds number (10(exp 4) less than Re(sub jet) less than 10(exp 5)); further development and full-scale Reynolds number testing are required, however, to determine if this technique can be made practical for the case of actual VTOL aircraft

Contractile units in disordered actomyosin bundles arise from F-actin buckling

Bundles of filaments and motors are central to contractility in cells. The classic example is striated muscle, where actomyosin contractility is mediated by highly organized sarcomeres which act as fundamental contractile units. However, many contractile bundles in vivo and in vitro lack sarcomeric organization. Here we propose a model for how contractility can arise in actomyosin bundles without sarcomeric organization and validate its predictions with experiments on a reconstituted system. In the model, internal stresses in frustrated arrangements of motors with diverse velocities cause filaments to buckle, leading to overall shortening. We describe the onset of buckling in the presence of stochastic actin-myosin detachment and predict that buckling-induced contraction occurs in an intermediate range of motor densities. We then calculate the size of the "contractile units" associated with this process. Consistent with these results, our reconstituted actomyosin bundles contract at relatively high motor density, and we observe buckling at the predicted length scale.Comment: 5 pages, 4 figures, Supporting text and movies attache

Development of Prognosis in Palliative care Study (PiPS) predictor models to improve prognostication in advanced cancer: prospective cohort study

OBJECTIVE: To develop a novel prognostic indicator for use in patients with advanced cancer that is significantly better than clinicians' estimates of survival. DESIGN: Prospective multicentre observational cohort study. SETTING: 18 palliative care services in the UK (including hospices, hospital support teams, and community teams). PARTICIPANTS: 1018 patients with locally advanced or metastatic cancer, no longer being treated for cancer, and recently referred to palliative care services. MAIN OUTCOME MEASURES: Performance of a composite model to predict whether patients were likely to survive for "days" (0-13 days), "weeks" (14-55 days), or "months+" (>55 days), compared with actual survival and clinicians' predictions. RESULTS: On multivariate analysis, 11 core variables (pulse rate, general health status, mental test score, performance status, presence of anorexia, presence of any site of metastatic disease, presence of liver metastases, C reactive protein, white blood count, platelet count, and urea) independently predicted both two week and two month survival. Four variables had prognostic significance only for two week survival (dyspnoea, dysphagia, bone metastases, and alanine transaminase), and eight variables had prognostic significance only for two month survival (primary breast cancer, male genital cancer, tiredness, loss of weight, lymphocyte count, neutrophil count, alkaline phosphatase, and albumin). Separate prognostic models were created for patients without (PiPS-A) or with (PiPS-B) blood results. The area under the curve for all models varied between 0.79 and 0.86. Absolute agreement between actual survival and PiPS predictions was 57.3% (after correction for over-optimism). The median survival across the PiPS-A categories was 5, 33, and 92 days and survival across PiPS-B categories was 7, 32, and 100.5 days. All models performed as well as, or better than, clinicians' estimates of survival. CONCLUSIONS: In patients with advanced cancer no longer being treated, a combination of clinical and laboratory variables can reliably predict two week and two month survival

Boundary Dissipation in a Driven Hard Disk System

A simulation is performed aiming at checking the existence of a well defined stationary state for a two dimensional system of driven hard disks when energy dissipation takes place at the system boundaries and no bulk impurities are presentComment: 5 pages, 7 figure

Frontostriatal Maturation Predicts Cognitive Control Failure to Appetitive Cues in Adolescents

Adolescent risk-taking is a public health issue that increases the odds of poor lifetime outcomes. One factor thought to influence adolescents' propensity for risk-taking is an enhanced sensitivity to appetitive cues, relative to an immature capacity to exert sufficient cognitive control. We tested this hypothesis by characterizing interactions among ventral striatal, dorsal striatal, and prefrontal cortical regions with varying appetitive load using fMRI scanning. Child, teen, and adult participants performed a go/no-go task with appetitive (happy faces) and neutral cues (calm faces). Impulse control to neutral cues showed linear improvement with age, whereas teens showed a nonlinear reduction in impulse control to appetitive cues. This performance decrement in teens was paralleled by enhanced activity in the ventral striatum. Prefrontal cortical recruitment correlated with overall accuracy and showed a linear response with age for no-go versus go trials. Connectivity analyses identified a ventral frontostriatal circuit including the inferior frontal gyrus and dorsal striatum during no-go versus go trials. Examining recruitment developmentally showed that teens had greater between-subject ventral-dorsal striatal coactivation relative to children and adults for happy no-go versus go trials. These findings implicate exaggerated ventral striatal representation of appetitive cues in adolescents relative to an intermediary cognitive control response. Connectivity and coactivity data suggest these systems communicate at the level of the dorsal striatum differentially across development. Biased responding in this system is one possible mechanism underlying heightened risk-taking during adolescence

Environmental Sensitivity and Experience Preferences In Outdoor Recreation Participation

In the past 30 years, a number of researchers have attempted to understand what makes people care about the environment or what underlies environmental sensitivity. Most of this research is rooted in the theory that environmental sensitivity (ES) is the first step in a developmental process that.leads persons in the direction of feeling what Chawla (1998) calls ownership and empowerment (p. 11) regarding protection of the environment· Some early researchers focused on.individuals\u27 self-claimed influences on environmental sensitivity based on significant life experiences (Peterson, 1982; Tanner, 1980}; while others attempted to find an association between outdoor participation and environmental concern (Dunlap & Heffernan, 1975; Geisler, Martinson,.& Wilkening, 1977; Theodori, Luloff, & Willits, 1998; VanLiere & Noe, 1981). Results from both approaches have often suggested a relationship between outdoor experiences and environmental sensitivity, but not consistently or strongly. Recognizing that outdoor recreation can be or mean many things, this study sought to determine if people with different levels of environmental sensitivity differ in the character of the outdoor experiences they prefer