14 research outputs found
Operationsplanung eloquenter Hirntumoren â vom inoperablen zum operablen Hirntumor
Auf Grundlage der vorliegenden Habilitationsschrift kann der Begriff des motorisch- und Sprach-eloquenten Hirntumors nunmehr objektiviert und genauer charakterisiert werden. Bei Patientinnen und Patienten mit bislang als inoperabel eingeschÀtzten Hirntumoren kann unter Einsatz der nTMS und der nTMS-basierten DTI-Traktografie eine differenziertere AbwÀgung zwischen Operationsrisiko und möglichem onkologischem Benefit einer Hirntumorresektion erfolgen.
Die Standardisierung der Pyramidenbahn-Traktografie im Rahmen der ersten Studie verbesserte mit Integration der funktionellen nTMS-Daten die Traktografie-QualitĂ€t und zeichnete sich zudem durch eine ausgezeichnete Interrater-ReliabilitĂ€t aus. Eine beeintrĂ€chtigte IntegritĂ€t der peritumoralen Pyramidenbahn kann durch die Diffusionsparameter FA und ADC charakterisiert werden und war mit einem erhöhten Risiko fĂŒr ein neues postoperatives motorisches Defizit assoziiert.
Die Erkenntnisse der ersten Arbeit wurden mit Analysen zuvor publizierter Arbeiten genutzt, um in der zweiten Studie die nTMS-basierte Risikostratifizierung bizentrisch zu validieren. Neben der topografischen Analyse (Infiltration des Motorkortex und Bestimmung der Tumor- Trakt-Distanz) erwiesen sich die FA und der RMT, welche die FaserbahnintegritÀt bzw. die ExzitabilitÀt des motorischen System reprÀsentieren, als entscheidende Parameter zur V orhersage des Operationsrisikos. So konnte ein verbessertes, auf einer Regressionsbaumanalyse basierendes Risikomodell zur Vorhersage des kurz- und langfristigen motorischen Outcomes entwickelt werden.
Im Rahmen der dritten Studie konnte gezeigt werden, dass die prĂ€operative Risikoanalyse die DurchfĂŒhrung des IOMs unterstĂŒtzen kann, indem subkortikale StimulationsintensitĂ€ten angepasst und unspezifische PhĂ€nomene wie transiente/partielle MEP- Amplitudenminderungen differenzierter interpretiert werden können. Somit kann eine hoch individualisierte Behandlungsstrategie fĂŒr Patientinnen und Patienten mit motorisch- eloquenten Hirntumoren gewĂ€hrleistet werden.
FĂŒr die Beurteilung Sprach-eloquenter Hirntumoren kommen sowohl das kortikale rTMS- Sprachmapping (als Negativmapping) sowie die DTI-basierte Traktografie des Sprachnetzwerks zum Einsatz. In der vierten Arbeit offenbarte der Vergleich aller bisher publizierten Algorithmen, dass die Platzierung anatomischer ROIs die besten Traktografie-
Ergebnisse hinsichtlich der Darstellbarkeit und PlausibilitĂ€t der Trakte offenbarte. Dieser Algorithmus wurde von internationalen Experten auch zur Operationsplanung und fĂŒr das Risiko-Assessment bevorzugt. Die Integration funktioneller rTMS-basierter ROIs ermöglichte die zusĂ€tzliche Darstellung von kortiko-subkortikalen Fasern, deren Relevanz fĂŒr das Sprachoutcome es in weiteren Studien zu untersuchen gilt.
Die Cluster-Analyse der fĂŒnften Studie identifizierte zwei Hochrisikoareale, die mit dem Auftreten eines neuen postoperativen Sprachdefizits assoziiert waren: 1. die temporo-parieto- occipitale Ăbergangszone und 2. der Temporalstamm der periinsulĂ€ren weiĂen Substanz. Der AF als V ertreter des dorsalen Systems zeigte sich als wichtigste Faserbahn fĂŒr die Sprachfunktion, deren Verletzung mit dem höchsten Risiko fĂŒr eine postoperative Sprachstörung assoziiert war. Eine SchĂ€digung des ventralen Faserbahnsystems spielte vor allem dann fĂŒr das postoperative Sprachoutcome eine Rolle, wenn sowohl die direkte Bahn (IFOF) als auch der indirekte Kreislauf (UF und ILF) betroffen waren.
Die hier dargelegten Technologien der nTMS und DTI-Traktografie ermöglichen fĂŒr motorisch- und Sprach-eloquente Hirntumoren eine differenzierte und individuelle Operationsplanung. Ziel zukĂŒnftiger Arbeiten wird es sein, diese Technologien weiter zu optimieren, um Hirntumoroperationen sicherer zu gestalten und damit die individuelle Patientenbehandlung zu verbessern
Low-frequency repetitive transcranial magnetic stimulation in patients with motor deficits after brain tumor resection: a randomized, double-blind, sham-controlled trial
Objective: Surgical resection of motor eloquent tumors poses the risk of causing postoperative motor deficits which leads to reduced quality of life in these patients. Currently, rehabilitative procedures are limited with physical therapy being the main treatment option. This study investigated the efficacy of repetitive navigated transcranial magnetic stimulation (rTMS) for treatment of motor deficits after supratentorial tumor resection.
Methods: This randomized, double-blind, sham-controlled trial (DRKS00010043) recruited patients with a postoperatively worsened upper extremity motor function immediately postoperatively. They were randomly assigned to receive rTMS (1Hz, 110% RMT, 15 minutes, 7 days) or sham stimulation to the motor cortex contralateral to the injury followed by physical therapy. Motor and neurological function as well as quality of life were assessed directly after the intervention, one month and three months postoperatively.
Results: Thirty patients were recruited for this study. There was no significant difference between both groups in the primary outcome, the Fugl Meyer score three months postoperatively [Group difference (95%-CI): 5.05 (-16.0; 26.1); p=0.631]. Patients in the rTMS group presented with better hand motor function one month postoperatively. Additionally, a subgroup of patients with motor eloquent ischemia showed lower NIHSS scores at all timepoints.
Conclusions: Low-frequency rTMS facilitated the recovery process in stimulated hand muscles, but with limited generalization to other functional deficits. Long-term motor deficits were not impacted by rTMS. Given the reduced life expectancy in these patients a shortened recovery duration of deficits can still be of high significance.
Clinical Trial Registration: https://drks.de/DRKS00010043.Peer Reviewe
Specific DTI seeding and diffusivity-analysis improve the quality and prognostic value of TMS-based deterministic DTI of the pyramidal tract
Object Navigated transcranial magnetic stimulation (nTMS) combined with
diffusion tensor imaging (DTI) is used preoperatively in patients with
eloquent-located brain lesions and allows analyzing non-invasively the spatial
relationship between the tumor and functional areas (e.g. the motor cortex and
the corticospinal tract [CST]). In this study, we examined the diffusion
parameters FA (fractional anisotropy) and ADC (apparent diffusion coefficient)
within the CST in different locations and analyzed their interrater
reliability and usefulness for predicting the patients' motor outcome with a
precise approach of specific region of interest (ROI) seeding based on the
color-coded FA-map. Methods Prospectively collected data of 30 patients
undergoing bihemispheric nTMS mapping followed by nTMS-based DTI fiber
tracking prior to surgery of motor eloquent high-grade gliomas were analyzed
by 2 experienced and 1 unexperienced examiner. The following data were
scrutinized for both hemispheres after tractography based on nTMS-motor
positive cortical seeds and a 2nd region of interest in one layer of the
caudal pons defined by the color-coded FA-map: the pre- and postoperative
motor status (day of discharge und 3 months), the closest distance between the
tracts and the tumor (TTD), the fractional anisotropy (FA) and the apparent
diffusion coefficient (ADC). The latter as an average within the CST as well
as specific values in different locations (peritumoral, mesencephal, pontine).
Results Lower average FA-values within the affected CST as well as higher
average ADC-values are significantly associated with deteriorated
postoperative motor function (p = 0.006 and p = 0.026 respectively). Segmental
analysis within the CST revealed that the diffusion parameters are especially
disturbed on a peritumoral level and that the degree of their impairment
correlates with motor deficits (FA p = 0.065, ADC p = 0.007). No significant
segmental variation was seen in the healthy hemisphere. The interrater
reliability showed perfect agreement for almost all analyzed parameters.
Conclusions Adding diffusion weighted imaging derived information on the
structural integrity of the nTMS-based tractography results improves the
predictive power for postoperative motor outcome. Utilizing a second
subcortical ROI which is specifically seeded based on the color-coded FA map
increases the tracking quality of the CST independently of the examiner's
experience. Further prospective studies are needed to validate the nTMS-based
prediction of the patient's outcome
Low-frequency repetitive transcranial magnetic stimulation in patients with motor deficits after brain tumor resection: a randomized, double-blind, sham-controlled trial
ObjectiveSurgical resection of motor eloquent tumors poses the risk of causing postoperative motor deficits which leads to reduced quality of life in these patients. Currently, rehabilitative procedures are limited with physical therapy being the main treatment option. This study investigated the efficacy of repetitive navigated transcranial magnetic stimulation (rTMS) for treatment of motor deficits after supratentorial tumor resection.MethodsThis randomized, double-blind, sham-controlled trial (DRKS00010043) recruited patients with a postoperatively worsened upper extremity motor function immediately postoperatively. They were randomly assigned to receive rTMS (1Hz, 110% RMT, 15 minutes, 7 days) or sham stimulation to the motor cortex contralateral to the injury followed by physical therapy. Motor and neurological function as well as quality of life were assessed directly after the intervention, one month and three months postoperatively.ResultsThirty patients were recruited for this study. There was no significant difference between both groups in the primary outcome, the Fugl Meyer score three months postoperatively [Group difference (95%-CI): 5.05 (-16.0; 26.1); p=0.631]. Patients in the rTMS group presented with better hand motor function one month postoperatively. Additionally, a subgroup of patients with motor eloquent ischemia showed lower NIHSS scores at all timepoints.ConclusionsLow-frequency rTMS facilitated the recovery process in stimulated hand muscles, but with limited generalization to other functional deficits. Long-term motor deficits were not impacted by rTMS. Given the reduced life expectancy in these patients a shortened recovery duration of deficits can still be of high significance.Clinical Trial Registrationhttps://drks.de/DRKS00010043
MRI-Based Risk Assessment for Incomplete Resection of Brain Metastases
Recent studies demonstrated that gross total resection of brain metastases
cannot always be achieved. Subtotal resection (STR) can result in an early recurrence and
might affect patient survival. We initiated a prospective observational study to establish a
MRI-based risk assessment for incomplete resection of brain metastases.Peer Reviewe
Comparison of anatomical-based vs. nTMS-based risk stratification model for predicting postoperative motor outcome and extent of resection in brain tumor surgery
The authors acknowledge the support of the Cluster of Excellence Matters of Activity. Image Space Material funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under GermanĂœs Excellence Strategy â EXC 2025. Dr. Rosenstock is participant in the BIH CharitĂ© Digital Clinician Scientist Program funded by the CharitĂ© â UniversitĂ€tsmedizin Berlin, and the Berlin Institute of Health at CharitĂ© (BIH). Dr. Belotti received fundings from the Italian Society of Neurosurgery - âPremio Melitta Grasso Tomaselloâ and the Beretta Foundation for Cancer Study - âEuropean Scholarship on Oncologyâ.Background:
Two statistical models have been established to evaluate characteristics associated with postoperative motor outcome in patients with glioma associated to the motor cortex (M1) or the corticospinal tract (CST). One model is based on a clinicoradiological prognostic sum score (PrS) while the other one relies on navigated transcranial magnetic stimulation (nTMS) and diffusion-tensor-imaging (DTI) tractography. The objective was to compare the models regarding their prognostic value for postoperative motor outcome and extent of resection (EOR) with the aim of developing a combined, improved model.
Methods:
We retrospectively analyzed a consecutive prospective cohort of patients who underwent resection for motor associated glioma between 2008 and 2020, and received a preoperative nTMS motor mapping with nTMS-based diffusion tensor imaging tractography. The primary outcomes were the EOR and the motor outcome (on the day of discharge and 3 months postoperatively according to the British Medical Research Council (BMRC) grading). For the nTMS model, the infiltration of M1, tumor-tract distance (TTD), resting motor threshold (RMT) and fractional anisotropy (FA) were assesed. For the PrS score (ranging from 1 to 8, lower scores indicating a higher risk), we assessed tumor margins, volume, presence of cysts, contrast agent enhancement, MRI index (grading white matter infiltration), preoperative seizures or sensorimotor deficits.
Results:
Two hundred and three patients with a median age of 50 years (range: 20â81 years) were analyzed of whom 145 patients (71.4%) received a GTR. The rate of transient new motor deficits was 24.1% and of permanent new motor deficits 18.8%. The nTMS model demonstrated a good discrimination ability for the short-term motor outcome at day 7 of discharge (AUC = 0.79, 95 %CI: 0.72â0.86) and the long-term motor outcome after 3 months (AUC = 0.79, 95 %CI: 0.71â0.87). The PrS score was not capable to predict the postoperative motor outcome in this cohort but was moderately associated with the EOR (AUC = 0.64; CI 0.55â0.72). An improved, combined model was calculated to predict the EOR more accurately (AUC = 0.74, 95 %CI: 0.65â0.83).
Conclusion:
The nTMS model was superior to the clinicoradiological PrS model for potentially predicting the motor outcome. A combined, improved model was calculated to estimate the EOR. Thus, patient counseling and surgical planning in patients with motor-associated tumors should be performed using functional nTMS data combined with tractography.Peer Reviewe
Effectiveness of Immune Checkpoint Inhibition vs Chemotherapy in Combination With Radiation Therapy Among Patients With NonâSmall Cell Lung Cancer and Brain Metastasis Undergoing Neurosurgical Resection
Importance: Patients with brain metastases from non-small cell lung cancer (NSCLC) have regularly been excluded from prospective clinical trials that include therapy with immune checkpoint inhibitors (ICIs). Clinical data demonstrating benefit with ICIs, specifically following neurosurgical brain metastasis resection, are scarce.
Objective: To evaluate and compare the association of radiation therapy with ICIs vs classic therapy involving radiation therapy and chemotherapy regarding overall survival in a cohort of patients who underwent NSCLC brain metastasis resection.
Design, setting and participants: This single-center 1:1 propensity-matched comparative effectiveness study at the largest neurosurgical clinic in Germany included individuals who had undergone craniotomy with brain metastasis resection from January 2010 to December 2021 with histologically confirmed NSCLC. Of 1690 patients with lung cancer and brain metastasis, 480 were included in the study. Key exclusion criteria were small-cell lung cancer, lack of tumor cells by means of histopathological analysis on brain metastasis resection, and patients who underwent biopsy without tumor resection. The association of overall survival with treatment with radiation therapy and chemotherapy vs radiation therapy and ICI was evaluated.
Exposures: Radiation therapy and chemotherapy vs radiation therapy and ICI following craniotomy and microsurgical brain metastasis resection.
Main outcomes and measures: Median overall survival.
Results: From the whole cohort of patients with NSCLC (N = 384). 215 (56%) were male and 169 (44%) were female. The median (IQR) age was 64 (57-72) years. The 2 cohorts of interest included 108 patients (31%) with radiation therapy and chemotherapy and 63 patients (16%) with radiation therapy and ICI following neurosurgical metastasis removal (before matching). Median (IQR) follow-up time for the total cohort was 47.9 (28.2-70.1) months with 89 patients (23%) being censored and 295 (77%) dead at the end of follow-up in December 2021. After covariate equalization using propensity score matching (62 patients per group), patients receiving radiation therapy and chemotherapy after neurosurgery had significantly lower overall survival (11.8 months; 95% CI; 9.1-15.2) compared with patients with radiation therapy and ICIs (23.0 months; 95% CI; 20.3-53.8) (P < .001).
Conclusions and relevance: Patients with NSCLC brain metastases undergoing neurosurgical resection had longer overall survival when treated with radiation therapy and ICIs following neurosurgery compared with those receiving platinum-based chemotherapy and radiation. Radiation and systemic immunotherapy should be regularly evaluated as a treatment option for these patients
PrĂ€operative Risikostratifizierung fuÌr das funktionelle Ergebnis bei Tumorresektionen in motorischen Arealen
Introduction. Navigated transcranial magnetic stimulation (nTMS) has been
established as a noninvasive examination method to identify preoperatively
functional motor areas in patients with brain tumors in presumed motor
eloquent areas. The aim of this study was to analyze in how far the data
provided by nTMS can be used to predict the risk for the occurence of a new or
the aggravation of a preoperatively existing paresis. Methods. One hundred
thirteen patients who were operated with glioma in presumed motor eloquent
areas in our department between October 2007 and December 2014 were
prospectively included for bihemispheric, preoperative nTMS mapping. The
examination results were transferred to the operation planning software iPlan
2.0 (Brain Lab) and fiber tracking of the corticospinal tract based on
diffusion tensor imaging was performed. Univariate analyses were used to
detect any correlations between the nTMS-derived variables and the
postoperative motor status on day 7 (= day of discharge) and after 3 months.
For creating a predictive model for the motor outcome, significant variables
were included into multiple ordinal logistic regression analysis. Results.
Deterioration of the motor status was observed in 20% of cases after 7 days
and in 22% of cases after 3 months. A new permanent deficit never occured when
the subcortical distance between the corticospinal tract and the tumor was
greater than 8 mm and the motor cortex was not infiltrated (p = 0.014).
Patients with a pathological interhemispheric excitability of the motor system
(interhemispheric resting motor threshold [RMT] ratio 110%) had a
higher risk to suffer from a new paresis on day 7 (p = 0.031). On the other
hand, patients with a preoperative deficit never regained motor function when
the RMT was significantly higher in the tumorous hemisphere than in the
healthy hemisphere (RMT ratio > 110%). Conclusion. The risk stratification
model allows to quantify the likelihood for worsening or improvement of motor
function based on objective functional-anatomical and neurophysiological data.
The data can be utilized to decide about the necessity for intraoperative
neurophysiological monitoring and to establish an individualized treatment
plan in consent with the patient.Einleitung. FĂŒr Patienten mit einem motorisch-eloquent gelegenen Hirntumor hat
sich die navigierte transkranielle Magnetstimulation (nTMS) als nicht-invasive
Untersuchungsmethode etabliert, um motorisch-funktionelle Areale prÀoperativ
zu identifizieren. Das Ziel dieser Studie war es zu analysieren, ob und
inwiefern sich die durch die nTMS-Untersuchung bereitgestellten Daten dazu
eignen, das Risiko fĂŒr das Auftreten einer neuen oder der Verschlechterung
einer bereits prÀoperativ bestehenden Parese in Form eines statistisch
prÀdiktiven Models zu stratifizieren. Methoden. Einhundertdreizehn Patienten,
die zwischen Oktober 2007 und Dezember 2014 an einem hirneigenen Tumor in
(potenziell) motorisch-eloquenter Lage in der Klinik fĂŒr Neurochirurgie der
Charité operiert wurden, unterzogen sich prÀoperativ der bihemisphÀrischen
nTMS-Untersuchung. AnschlieĂend erfolgte die Evaluation in der OP-
Planungssoftware iPlan 2.0 (Brain Lab), mit welcher eine auf Diffusions-
Tensor-Bildgebung basierende Faserbahndarstellung des kortikospinalen Traktes
erfolgte. Mit den prospektiv gesammelten Daten erfolgte zunÀchst eine
univariate Analyse bzgl. des motorischen Status nach 7 Tagen (=
Entlassungstag) und 3 Monaten. AnschlieĂend wurde mithilfe der signifkanten
Variablen eine multiple ordinale logistische Regressionsanalyse durchgefĂŒhrt,
um PrĂ€diktoren fĂŒr das motorische Outcome der Patienten zu identifizieren.
Ergebnisse. Ein verschlechterter motorischer Status wurde in 20% der FĂ€lle
nach 7 Tagen und in 22% der FĂ€lle nach 3 Monaten beobachtet. Patienten
erlitten nie ein neues motorisches Defizit, wenn der minimale subkortikale
Abstand zwischen dem Tumor und der nTMS-basierten Darstellung des
kortikospinalen Traktes gröĂer als 8mm war und keine kortikale tumoröse
Infiltration des Motorkortex nachweisbar war (p = 0.014). Eine postoperative
motorische Verschlechterung nach 7 Tagen war mit einem pathologischen
interhemisphĂ€rischen ErregungsverhĂ€ltnis (interhemisphĂ€rischer âresting motor
thresholdâ (RMT)-Quotient 110%) assoziiert (p = 0.031). Eine
prÀoperative Parese bildete sich bei Patienten, deren RMT-Quotient > 110% lag,
nie zurĂŒck. Zusammenfassung. Die auf anatomisch-funktionellen und
neurophysiologischen Daten basierende Risikostratifizierung erlaubt es, die
Wahrscheinlichkeit fĂŒr eine motorisch-funktionelle Verschlechterung bzw.
Besserung zu quantifizieren. Diese Information kann genutzt werden, um die
Notwendigkeit von intraoperativem neurophysiologischen Monitoring
einzuschÀtzen und in Konsens mit dem Patienten eine individualisierte
Behandlungsstrategie festzulegen
Predicting the Extent of Resection of Motor-Eloquent Gliomas Based on TMS-Guided Fiber Tracking
Background: Surgical planning with nTMS-based tractography is proven to increase safety during surgery. A preoperative risk stratification model has been published based on the M1 infiltration, RMT ratio, and tumor to corticospinal tract distance (TTD). The correlation of TTD with corticospinal tract to resection cavity distance (TRD) and outcome is needed to further evaluate the validity of the model. Aim of the study: To use the postop MRI-derived resection cavity to measure how closely the resection cavity approximated the preoperatively calculated corticospinal tract (CST) and how this correlates with the risk model and the outcome. Methods: We included 183 patients who underwent nTMS-based DTI and surgical resection for presumed motor-eloquent gliomas. TTD, TRD, and motor outcome were recorded and tested for correlations. The intraoperative monitoring documentation was available for a subgroup of 48 patients, whose responses were correlated to TTD and TRD. Results: As expected, TTD and TRD showed a good correlation (Spearmanâs Ï = 0.67, p < 0.001). Both the TTD and the TRD correlated significantly with the motor outcome at three months (Kendallâs Tau-b 0.24 for TTD, 0.31 for TRD, p < 0.001). Interestingly, the TTD and TRD correlated only slightly with residual tumor volume, and only after correction for outliers related to termination of resection due to intraoperative monitoring events or the proximity of other eloquent structures (TTD Ï = 0.32, p < 0.001; TRD Ï = 0.19, p = 0.01). This reflects the fact that intraoperative monitoring (IOM) phenomena do not always correlate with preoperative structural analysis, and that additional factors influence the intraoperative decision to abort resection, such as the adjacency of other vulnerable structures. The TTD was also significantly correlated with variations in motor evoked potential (MEP) responses (no/reversible decrease vs. irreversible decrease; p = 0.03). Conclusions: The TTD approximates the TRD well, confirming the best predictive parameter and giving strength to the nTMS-based risk stratification model. Our analysis of TRD supports the use of the nTMS-based TTD measurement to estimate the resection preoperatively, also confirming the 8 mm cutoff. Nevertheless, the TRD proved to have a slightly stronger correlation with the outcome as the surgeonâs experience, anatomofunctional knowledge, and MEP observations influence the expected EOR
Preoperative nTMS and Intraoperative Neurophysiology - A Comparative Analysis in Patients With Motor-Eloquent Glioma
Background The resection of a motor-eloquent glioma should be guided by intraoperative neurophysiological monitoring (IOM) but its interpretation is often difficult and may (unnecessarily) lead to subtotal resection. Navigated transcranial magnetic stimulation (nTMS) combined with diffusion-tensor-imaging (DTI) is able to stratify patients with motor-eloquent lesion preoperatively into high- and low-risk cases with respect to a new motor deficit. Objective To analyze to what extent preoperative nTMS motor risk stratification can improve the interpretation of IOM phenomena. Methods In this monocentric observational study, nTMS motor mapping with DTI fiber tracking of the corticospinal tract was performed before IOM-guided surgery for motor-eloquent gliomas in a prospectively collected cohort from January 2017 to October 2020. Descriptive analyses were performed considering nTMS data (motor cortex infiltration, resting motor threshold (RMT), motor evoked potential (MEP) amplitude, latency) and IOM data (transcranial MEP monitoring, intensity of monopolar subcortical stimulation (SCS), somatosensory evoked potentials) to examine the association with the postoperative motor outcome (assessed at day of discharge and at 3 months). Results Thirty-seven (56.1%) of 66 patients (27 female) with a median age of 48 years had tumors located in the right hemisphere, with glioblastoma being the most common diagnosis with 39 cases (59.1%). Three patients (4.9%) had a new motor deficit that recovered partially within 3 months and 6 patients had a persistent deterioration (9.8%). The more risk factors of the nTMS risk stratification model (motor cortex infiltration, tumor-tract distance (TTD) 8mm deteriorated. Irreversible MEP amplitude decrease >50% was associated with worse motor outcome in all patients, while a MEP amplitude decrease <= 50% or lower SCS intensities <= 4mA were particularly correlated with a postoperative worsened motor status in nTMS-stratified high-risk cases. No patient had postoperative deterioration of motor function (except one with partial recovery) when intraoperative MEPs remained stable or showed only reversible alterations. Conclusions The preoperative nTMS-based risk assessment can help to interpret ambiguous IOM phenomena (such as irreversible MEP amplitude decrease <= 50%) and adjustment of SCS stimulation intensity