A Survey on Smart Grid-Connected Photovoltaic Power Systems and Its Issues

Photovoltaic power generation refers to the use of solar photovoltaic cells to the solar radiation can be directly transformed into electricity generation. Distributed photovoltaic power generation, refers to the construction in the vicinity of the user's location, the operation mode to the user side of spontaneous self-occupied mainly, the excess power on the Internet, and in the distribution system to balance the characteristics of the photovoltaic power generation facilities. Distributed photovoltaic power generation follow the principle of local conditions, clean and efficient, decentralized layout, the principle of the nearest use, and make full use of local solar energy resources, alternative and reduce fossil energy consumption. This paper aims to investigate and emphasize the importance of the grid-connected PV system. The investigation was conducted to critically review the literature on expected potential problems associated with issues of PV based grid system. The main purpose of this paper is to discuss the basic understanding of photovoltaic (PV) based distributed generation power system and how these power flows will influence the performance and stability of a power system. Some of the PV grid integration issues such as voltage regulation, voltage sags, harmonic distortion, etc are also discussed and possible solutions are also mentioned

Outsourcing Trends in University Libraries

Outsourcing means to source from outside or in other words getting another person or organization to provide a service on a contractual basis.It can be very helpful for Libraries and any other management. The paper lists the activities that can be outsourced. It also outlines the advantages ad disadvantages of oursourcing

Some Fixed point Theorems in Generalization Metric space

In this paper we establish some fixed point results for mapping satisfying sufficient contractive conditions on a complete G-metric space. Key words and phrases: Metric space, generalized metric space

The Role of Transforming Growth Factorβ (TGF-β)-activated Kinase 1 (TAK1) in Retinal Development

poster abstractPurpose: The formation of the retina is dependent on multiple transcription factors being expressed in the correct time and place. Transforming growth factor-β-activated kinase1 (TAK1), a serine threonine kinase, has been increasingly associated with regulation of proliferation, differentiation and apoptosis of many cell types both within and outside of the central nervous system. However, little is known about its role in development of the retina. Previous results from our lab have indicated that TAK1 is expressed throughout the developing retina; however activated TAK1 is found predominantly in the dividing progenitors of the early developing chick retina. Retinas injected with TAK1 inhibitor appeared to have an increase in progenitor population and a decrease in differentiating retinal ganglion cells. The present study evaluated the potential role of TAK1 in inducing apoptosis in the developing chick retina. Methods: Embryonic day 3(E3) chick retina were injected with vehicle and 1.0 M or 2.0 M concentration (5Z)-7-Oxozeaenol, an irreversible inhibitor of TAK1. 24 hours post inhibition the tissue was harvested. Immunohistochemistry (IHC) was performed to analyze the levels of cleaved caspase 3 expression, a protein activated during apoptosis. Nuclei stained with DAPI were used to quantify the number of cells expressing the caspase3. Lipopolysaccharide (LPS) treated adult, postnatal 30 (P30), mouse retina was used as a positive control for our IHC. Results: No difference in the level of cleaved (activated) caspase 3 immunolabel was found in vehicle-, 1.0 and 2.0 M inhibitor-injected retinas. Conclusion: Lack of cleaved caspase 3 immunolabel in TAK1-inhibited retinas indicates that TAK1 may not be playing any role in inducing cell death through apoptosis in the developing chick retina used in our study. These preliminary results suggest further research should be done to better understand its role in retinal development. Mentors: Teri Belecky-Adams and Sarika Tiwari, Center for Regenerative Biology and Medicine, IUPUI, Department of Biology, IUPU

THE EFFECT OF HDAC INHIBITORS ON RETINAL DEVELOPMENT OF CHICK EMBRYO

poster abstractIntroduction: Gene expression is regulated by the accessibility of regulatory cis-acting DNA elements as well as availability of transcription factors. Histone deacetylase (HDAC) can regulate gene expression by deacetylating histone tails, which leads to a closed conformation of the DNA/histone complex and generally a reduction in expression. HDACs have been proposed to play a key role in cell survival, proliferation and differentiation; however, fewer studies have been focusing on the role of HDACs in the developing vertebrate retina. Methods: Chick retinal explants were treated with vehicle (dimethyl sulphoxide(DMSO)) or 1.0 M Trichstatin A (TSA), a known inhibitor of class 1 and 2 HDACs. Immunohistochemistry (IHC) was performed to analyze the levels of cleaved caspase 3, a protein activated during apoptosis, phospho-histone 3 (pH3) marker for mitotic phase, SOX2 which marks progenitor cells, and Islet-1 which marks differentiated cells. Digital images were analyzed using Image J/FIJI software for numbers of labeled cells. Results: After treatment with control or TSA, numbers of progenitor and differentiating cells were quantified. TSA-treated samples showed a statistically significant increase in SOX2+ (progenitors) and an increase in islet-1+ (differentiating) cells. To assess if any differences in proliferation and/or cell death that might lead to an increase in the number of progenitor and differentiating cells, samples were labeled for pH3 or cleaved caspase 3. Treatment with TSA led to increases in cells positive for pH3 and a statistically significant increase in cells positive for cleaved caspase 3 compared to controls. Conclusions: HDAC inhibitor, TSA, increased the number of progenitor and differentiating cells by increasing proliferation within the developing retina. However, there was also an increase in the number of cells undergoing apoptosis. Ongoing studies will determine which HDACs may be responsible for these results

Outsourcing Trends in University Libraries

Outsourcing means to source from outside or in other words getting another person or organization to provide a service on a contractual basis.It can be very helpful for Libraries and any other management. The paper lists the activities that can be outsourced. It also outlines the advantages ad disadvantages of oursourcing

Histone deacetylase expression patterns in developing murine optic nerve

BACKGROUND: Histone deacetylases (HDACs) play important roles in glial cell development and in disease states within multiple regions of the central nervous system. However, little is known about HDAC expression or function within the optic nerve. As a first step in understanding the role of HDACs in optic nerve, this study examines the spatio-temporal expression patterns of methylated histone 3 (K9), acetylated histone 3 (K18), and HDACs 1–6 and 8–11 in the developing murine optic nerve head. RESULTS: Using RT-qPCR, western blot and immunofluorescence, three stages were analyzed: embryonic day 16 (E16), when astrocyte precursors are found in the optic stalk, postnatal day 5 (P5), when immature astrocytes and oligodendrocytes are found throughout the optic nerve, and P30, when optic nerve astrocytes and oligodendrocytes are mature. Acetylated and methylated histone H3 immunoreactivity was co-localized in the nuclei of most SOX2 positive glia within the optic nerve head and adjacent optic nerve at all developmental stages. HDACs 1–11 were expressed in the optic nerve glial cells at all three stages of optic nerve development in the mouse, but showed temporal differences in overall levels and subcellular localization. HDACs 1 and 2 were predominantly nuclear throughout optic nerve development and glial cell maturation. HDACs 3, 5, 6, 8, and 11 were predominantly cytoplasmic, but showed nuclear localization in at least one stage of optic nerve development. HDACs 4, 9 and10 were predominantly cytoplasmic, with little to no nuclear expression at any time during the developmental stages examined. CONCLUSIONS: Our results showing that HDACs 1, 2, 3, 5, 6, 8, and 11 were each localized to the nuclei of SOX2 positive glia at some stages of optic nerve development and maturation and extend previous reports of HDAC expression in the aging optic nerve. These HDACs are candidates for further research to understand how chromatin remodeling through acetylation, deacetylation and methylation contributes to glial development as well as their injury response

Class I histone deacetylases in retinal progenitors and differentiating ganglion cells

Background The acetylation state of histones has been used as an indicator of the developmental state of progenitor and differentiating cells. The goal of this study was to determine the nuclear localization patterns of Class I histone deacetylases (HDACs) in retinal progenitor cells (RPCs) and retinal ganglion cells (RGCs), as the first step in understanding their potential importance in cell fate determination within the murine retina. Results The only HDAC to label RPC nuclei at E16 and P5 was HDAC1. In contrast, there was generally increased nuclear localization of all Class I HDACs in differentiating RGCs. Between P5 and P30, SOX2 expression becomes restricted to Müller glial, cholinergic amacrine cells, and retinal astrocytes. Cholinergic amacrine showed a combination of changes in nuclear localization of Class I HDACs. Strikingly, although Müller glia and retinal astrocytes express many of the same genes, P30 Müller glial cells showed nuclear localization only of HDAC1, while retinal astrocytes were positive for HDACs 1, 2, and 3. Conclusion These results indicate there may be a role for one or more of the Class I HDACs in retinal cell type-specific differentiation

Vehicle-to-Grid Integration for Enhancement of Grid: A Distributed Resource Allocation Approach

In the future grids, to reduce greenhouse gas emissions Electric Vehicles (EVs) seems to be an important means of transportation. One of the major disadvantages of the future grid is the demand-supply mismatch which can be mitigated by incorporating the EVs into the grid. The paper introduces the concept of the Distributed Resource Allocation (DRA) approach for incorporating a large number of Plug-in EV (PEVs) with the power grid utilizing the concept of achieving output consensus. The charging/discharging time of all the participating PEVs are separated with respect to time slots and are considered as strategies. The major aim of the paper is to obtain a favorable charging strategy for each grid-connected PEVs in such a way that it satisfies both grid objectives in terms of load profile smoothening and minimizing of load shifting as well as economic and social interests of vehicle owners i.e. a fair share of the rate of charging for all connected PEVs. The three-fold contribution of the paper in smoothening of load profile, load shifting minimization, and fair charging rate is validated using a representative case study. The results confirm improvement in load profile and also highlight a fair deal in the charging rate for each PEV

Formulation and evaluation of in situ herbal gel containing aqueous and methanolic extract of fruits of Quercus infectoria Oliv. for vaginal application

Conventional vaginal dosage forms frequently produce leakages and drip. There is a need for the development of innovative vaginal formulation technology that fulfills certain criteria such as desirable product dispersion throughout the vagina, retention for intended intervals, and adequate release of drug. These features can be achieved by the use of bioadhesive based novel delivery systems. In-situ gelation is a process of gel formation at the site of application after the composition or formulation has been applied the site. Formulation and evaluation of one such bioadhesive based novel drug delivery system for an effective and patient friendly use of an antifungal drug to formulated In-situ gel. Quercus infectoria is medicinally important plant grown wildly in India and is useful in the treatment of fungal and microbial infection by tribal’s of India. The plant is used by tribal women to treat vaginal infection as mentioned in folk-lore. Therefore, the present plant as selected to formulate in-situ herbal gel using Quercus infectoria as active ingredients for the treatment of vaginal infection. Keywords: Herbal Gels, Quercus infectoria, bioadhesive, vaginal drug deliver