Chemoenzymatic Probes for Detecting and Imaging Fucose-α(1-2)-galactose Glycan Biomarkers

The disaccharide motif fucose-α(1-2)-galactose (Fucα(1-2)Gal) is involved in many important physiological processes, such as learning and memory, inflammation, asthma, and tumorigenesis. However, the size and structural complexity of Fucα(1-2)Gal-containing glycans have posed a significant challenge to their detection. We report a new chemoenzymatic strategy for the rapid, sensitive detection of Fucα(1-2)Gal glycans. We demonstrate that the approach is highly selective for the Fucα(1-2)Gal motif, detects a variety of complex glycans and glycoproteins, and can be used to profile the relative abundance of the motif on live cells, discriminating malignant from normal cells. This approach represents a new potential strategy for biomarker detection and expands the technologies available for understanding the roles of this important class of carbohydrates in physiology and disease

Development of interactive dialogue simulator for studying functional disorders of children's digestive organs

The purpose of the study is the article is devoted to the development of an interactive simulator for the study of children's FDDS.Цель исследования. Статья посвящена разработке интерактивного диалогового тренажера для изучения ФРОП у детей

Satisfaction with the educational process: the students’ opinion

Results of questioning of students of pediatric faculty on satisfaction with quality of educational process are presented in article. Individual questionnaire of students of a third year of pediatric faculty upon termination of studying of disciplines “Propaedeutics of children’s diseases” and “Bases of formation of health of the children” realized within the main educational program in “Pediatrics” is conducted. Results of questioning have shown that in general the students of a third year studying in “Pediatrics” are satisfied with the organization and quality of educational process at department of faculty pediatrics and propaedeutics of children’s diseases.В статье представлены результаты анкетирования студентов педиатрического факультета по удовлетворенности качеством образовательного процесса. Проведен индивидуальный анкетный опрос студентов третьего курса педиатрического факультета по окончании изучения дисциплин «Пропедевтика детских болезней» и «Основы формирования здоровья детей», реализуемых в рамках основной образовательной программы по специальности «Педиатрия». Результаты анкетирования показали, что в целом студенты третьего курса, обучающиеся по специальности «Педиатрия», удовлетворены организацией и качеством учебного процесса на кафедре факультетской педиатрии и пропедевтики детских болезней

Experience of development and implementation of electronic diary of student in work practice on the pediatric faculty

The article discusses the experience of the organization of the educational process during the practical training of students. The description of work with electronic documentation for the purpose of operative communication between the teacher and the student is given. Convenience in work and prospects of further development of this educational technology are shownВ статье рассматривается опыт организации образовательного процесса в ходе производственной практики студентов. Приводится описание работы с электронной документацией с целью оперативной связи между преподавателем и студентом. Показаны удобство в работе и перспективность дальнейшей разработки данной образовательной технологии

Eco-Taxonomic Insights into Actinomycete Symbionts of Termites for Discovery of Novel Bioactive Compounds

Termites play a major role in foraging and degradation of plant biomass as well as cultivating bioactive microorganisms for their defense. Current advances in "omics'' sciences are revealing insights into function-related presence of these symbionts, and their related biosynthetic activities and genes identified in gut symbiotic bacteria might offer a significant potential for biotechnology and biodiscovery. Actinomycetes have been the major producers of bioactive compounds with an extraordinary range of biological activities. These metabolites have been in use as anticancer agents, immune suppressants, and most notably, as antibiotics. Insect-associated actinomycetes have also been reported to produce a range of antibiotics such as dentigerumycin and mycangimycin. Advances in genomics targeting a single species of the unculturable microbial members are currently aiding an improved understanding of the symbiotic interrelationships among the gut microorganisms as well as revealing the taxonomical identity and functions of the complex multilayered symbiotic actinofloral layers. If combined with target-directed approaches, these molecular advances can provide guidance towards the design of highly selective culturing methods to generate further information related to the physiology and growth requirements of these bioactive actinomycetes associated with the termite guts. This chapter provides an overview on the termite gut symbiotic actinoflora in the light of current advances in the "omics'' science, with examples of their detection and selective isolation from the guts of the Sunshine Coast regional termite Coptotermes lacteus in Queensland, Australia