Neutrino Masses via the Zee Mechanism in 5D split fermions model

We study the Zee model in the framework of the split fermion model in $M_4\times S_1/Z_2$ spacetime. Neutrino masses are generated through 1-loop diagrams without the right-handed neutrinos introduced. By assuming an order one anarchical complex 5D Yukawa couplings, all the effective 4D Yukawa couplings are determined by the wave function overlap between the split fermions and the bulk scalars in the fifth dimension. The predictability of the Yukawa couplings is in sharp contrast to the original Zee model in 4D where the Yukawa couplings are unknown free parameters. This setup exhibits a geometrical alternative to the lepton flavor symmetry. By giving four explicit sets of the split fermion locations, we demonstrate that it is possible to simultaneously fit the lepton masses and neutrino oscillation data by just a handful free parameters without much fine tuning. Moreover, we are able to make definite predictions for the mixing angle $\theta_{13}$, the absolute neutrino masses, and the lepton flavor violation processes for each configuration.Comment: 16 pages, 2 figure

Very large G protein-coupled receptor 1 regulates myelin-associated glycoprotein via Gαs/Gαq-mediated protein kinases A/C.

VLGR1 (very large G protein-coupled receptor 1), also known as MASS1 (monogenic audiogenic seizure susceptible 1), is an orphan G protein-coupled receptor that contains a large extracellular N terminus with 35 calcium-binding domains. A truncating mutation in the Mass1 gene causes autosomal recessive, sound-induced seizures in the Frings mouse. However, the function of MASS1 and the mechanism underlying Frings mouse epilepsy are not known. Here, we found that MASS1 protein is enriched in the myelinated regions of the superior and inferior colliculi, critical areas for the initiation and propagation of audiogenic seizures. Using a panel of myelin antibodies, we discovered that myelin-associated glycoprotein (MAG) expression is dramatically decreased in Frings mice. MASS1 inhibits the ubiquitylation of MAG, thus enhancing the stability of this protein, and the calcium-binding domains of MASS1 are essential for this regulation. Furthermore, MASS1 interacts with Gαs/Gαq and activates PKA and PKC in response to extracellular calcium. Suppression of signaling by MASS1 RNAi or a specific inhibitor abrogates MAG up-regulation. We postulate that MASS1 senses extracellular calcium and activates cytosolic PKA/PKC pathways to regulate myelination by means of MAG protein stability in myelin-forming cells of the auditory pathway. Further work is required to determine whether MAG dysregulation is a cause or consequence of audiogenic epilepsy and whether there are other pathways regulated by MASS1

On the Translation of Chinese Webcomics: A Case Study of My Dear Highness

This paper discusses how to translate Chinese webcomic strips using My Dear Highness as an example. In our translation practice, such methods as variation translation, omission, and shift were adopted to deal with address forms or lengthy sentences, while free translation was used to deal with four-character structures and culture-loaded words or phrases in the original text to the effect that the intended meaning of the source text can be accurately conveyed to target readers under a multimodal context. We believe that whatever methods are used, the ultimate purpose of translation remains the same, and that is, the reading experience provided by the original text can be restored to the greatest possible extent

Information technology adoption models in retailing industry

The purpose of this study, which drew upon an implementation model of information technology to apply a systematic strategy for services innovations in Taiwan's retailing industry. The two major differences between the business model before and after importing an information system were as follows. One was the improvement in internal operational efficiency, such as the information exchanged between suppliers or companies. The other was the optimization of consumer services, which created different new services and features. Based on DOI (diffusion of innovation) theory, importing an information system into a supermarket chain was analyzed using the ICT (information communications technology) and improved service processing was thus obtained. The results showed that retailing industry presented an in-depth discussion of the strategies, models and important factors used to upgrade its efficiency and business performance. Doing this would increase customers' satisfaction, creating loyal customers, and result in favorable word-of-mouth marketing. This enterprise intercompany transfer cargo efficient to reduce the stock rate would be beneficial to both suppliers and customers

An error bound for the MAOR method

AbstractSuppose Aχ = b is a system of linear equations where the matrix A is symmetric positive definite and consistently ordered. A bound for the norm of the errors εk = χ − χk of the MAOR method in terms of the norms of δk = χk − χk−1 and δk+1 = χk+1 − χk and their inner product is derived, ∥ϵk∥22≥1ω2{(|(w1 − 1)(w2 − 1)| + |w1(γ − w2)|μ22)2∥δk∥12 − 2(w1 − 1) 〈δk,δk+1〉 + 2|w1(ω − w2)|μ12∥δk∥2∥+∥δk+1∥2 + ∥δk+1∥22

Selection Determinants In Education Major Graduates Occupations

Taiwan’s teacher training system currently faces a serious disorder. The excessive number of teacher education programs being set up in universities by the Ministry of Education has dramatically increased the number of teachers. The situation, coupled with the country of low birth rate and high retirement age, brings about fewer teaching vacancies than the number of available teachers. The over-expansion of universities has resulted in a situation that almost every secondary school graduate can access higher education institutions, which subsequently produce a great number of graduates, far exceeding the vacancies in the workplace. This plus with the recent economic recession intensifies competition among individuals hunting for jobs. Thus, it is imperative to identify the ideal jobs for graduates, and the first step is figuring out the main determinants for selecting jobs and the relative importance of these determinants. A self-developed questionnaire was administered to 200 education major graduates in Taiwan. The result indicated that high job stability was perceived to be the most important factor among participants. Also, the education students considered school teacher or administrator to be the ideal jobs

A Chemical and Enzymatic Approach to Study Site-Specific Sumoylation.

A variety of cellular pathways are regulated by protein modifications with ubiquitin-family proteins. SUMO, the Small Ubiquitin-like MOdifier, is covalently attached to lysine on target proteins via a cascade reaction catalyzed by E1, E2, and E3 enzymes. A major barrier to understanding the diverse regulatory roles of SUMO has been a lack of suitable methods to identify protein sumoylation sites. Here we developed a mass-spectrometry (MS) based approach combining chemical and enzymatic modifications to identify sumoylation sites. We applied this method to analyze the auto-sumoylation of the E1 enzyme in vitro and compared it to the GG-remnant method using Smt3-I96R as a substrate. We further examined the effect of smt3-I96R mutation in vivo and performed a proteome-wide analysis of protein sumoylation sites in Saccharomyces cerevisiae. To validate these findings, we confirmed several sumoylation sites of Aos1 and Uba2 in vivo. Together, these results demonstrate that our chemical and enzymatic method for identifying protein sumoylation sites provides a useful tool and that a combination of methods allows a detailed analysis of protein sumoylation sites