Alters- und geschlechtsspezifische Unterschiede bei der Nutzung einer P300-basierten Brain Computer Interfaces: Eine Studie ereigniskorrelierter EEG-Oszillationen

Brain-Computer-Interfaces (BCI) are currently a subject of high interest in the field of rehabilitation technology. BCI will allow patients without control of their muscles to access certain functions of a computer, eg a speller for communication. Especially the possibility to establish methods of communication for the paralyzed is a main focus of BCI research. Among others, one common approach for Brain-Computer-Interfacing is the P300-Speller. It applies a modified Oddball-Paradigm to evoke a P300-Komponente, which is subsequently detected by automated means. Detection of the P300-Wave is connected to the related character, which is then displayed on a computer screen. The P300-Speller is an established method in laboratory research; still it is not yet applied in a clinical setting. Most applications and tests, using the P300-Speller, still take place in young, healthy subjects. This study investigates differences in the P300-Speller usability between male and female users as well as between young and old users. Under certain conditions, i.e. difficult conditions, robust and reproducible differences are found. Aged men are worse in their ability to use the speller than young men and women of both age groups. In a visual Oddball-Paradigm, bad performance in the P300-Speller is reflected in event-related EEG oscillations. Especially in the frequency bands associated with attention, the group with the worst performance shows less pronounced signals than the other experimental groups. It is concluded, that older men s attention is less pronounced than that in the other groups, effecting EEG-Oscillations and performance in the P300-Speller. A visual Oddball-Paradigm may be suitable as a predictor for a persons ability to use the P300-Speller

Efficacy, safety and pharmacokinetics of a new high-purity factor X concentrate in subjects with hereditary factor X deficiency.

IntroductionHereditary factor X (FX) deficiency is a rare bleeding disorder affecting 1:500 000 to 1:1 000 000 of individuals. Until recently, no specific replacement factor concentrate was available.AimThe aim of this study was to assess safety and efficacy of a new, high‐purity plasma‐derived FX concentrate (pdFX) in subjects with hereditary FX deficiency.MethodsSubjects aged ≥12 years with moderate or severe FX deficiency (plasma FX activity <5 IU dL−1) received 25 IU kg−1 pdFX as on‐demand treatment or short‐term prophylaxis for 6 months to 2 years. Subjects assessed pdFX efficacy for each bleed; at end‐of‐study, investigators assessed overall pdFX efficacy. Blood samples for pharmacokinetic analysis were obtained at baseline and ≥6 months. Safety was assessed by adverse events (AEs), inhibitor development and changes in laboratory parameters.ResultsSixteen enrolled subjects (six aged 12–17 years; 10 aged 18–58 years) received a total of 468 pdFX infusions. In the 187 analysed bleeds, pdFX efficacy was categorized as excellent, good, poor or unassessable in 90.9%, 7.5%, 1.1% and 0.5% of bleeds respectively; 83% of bleeds were treated with one infusion. For pdFX, mean (median; interquartile range) incremental recovery and half‐life were 2.00 (2.12; 1.79–2.37) IU dL−1 per IU kg−1 and 29.4 (28.6; 25.8–33.1) h respectively. No serious AEs possibly related to pdFX or evidence of FX inhibitors were observed, and no hypersensitivity reactions or clinically significant trends were detected in laboratory parameters.ConclusionThese results demonstrate that a dose of 25 IU kg−1 pdFX is safe and efficacious for on‐demand treatment and short‐term prophylaxis in subjects with moderate or severe hereditary FX deficiency

Age and gender effects in the usabillity of a P300 based brain computer interface: A study of event related EEG-oscillations

Brain-Computer-Interfaces (BCI) are currently a subject of high interest in the field of rehabilitation technology. BCI will allow patients without control of their muscles to access certain functions of a computer, eg a speller for communication. Especially the possibility to establish methods of communication for the paralyzed is a main focus of BCI research. Among others, one common approach for Brain-Computer-Interfacing is the P300-Speller. It applies a modified Oddball-Paradigm to evoke a P300-Komponente, which is subsequently detected by automated means. Detection of the P300-Wave is connected to the related character, which is then displayed on a computer screen. The P300-Speller is an established method in laboratory research; still it is not yet applied in a clinical setting. Most applications and tests, using the P300-Speller, still take place in young, healthy subjects. This study investigates differences in the P300-Speller usability between male and female users as well as between young and old users. Under certain conditions, i.e. difficult conditions, robust and reproducible differences are found. Aged men are worse in their ability to use the speller than young men and women of both age groups. In a visual Oddball-Paradigm, bad performance in the P300-Speller is reflected in event-related EEG oscillations. Especially in the frequency bands associated with attention, the group with the worst performance shows less pronounced signals than the other experimental groups. It is concluded, that older men s attention is less pronounced than that in the other groups, effecting EEG-Oscillations and performance in the P300-Speller. A visual Oddball-Paradigm may be suitable as a predictor for a persons ability to use the P300-Speller

Spontaneous Intestinal Perforation: An Atypical Presentation of Neutropenic Enterocolitis—A Case Report

Background. Neutropenic enterocolitis is one of the most common gastrointestinal complications seen in patients who are receiving chemotherapy for leukemia. Severe neutropenia is the main underlying factor of this pathology. It is characterized by fever and abdominal pain. Case Presentation. Herein, we report a case of neutropenic enterocolitis which presented with intestinal perforation in an afebrile patient who was diagnosed with acute lymphoblastic leukemia and was receiving induction chemotherapy. Conclusion. We aimed to emphasize the importance of enterocolitis and increase awareness against such severe complications which could have unexpected presentations

Use of a High-Purity Factor X Concentrate in Turkish Subjects with Hereditary Factor X Deficiency: Post Hoc Cohort Subanalysis of a Phase 3 Study

Hereditary factor X (FX) deficiency is a rare bleeding disorder more prevalent in countries with high rates of consanguineous marriage. In a prospective, open-label, multicenter phase 3 study, 25 IU/kg plasma-derived factor X (pdFX) was administered as on-demand treatment or short-term prophylaxis for 6 months to 2 years. In Turkish subjects (n=6), 60.7% of bleeds were minor. A mean of 1.03 infusions were used to treat each bleed, and mean total dose per bleed was 25.38 IU/kg. Turkish subjects rated pdFX efficacy as excellent or good for all 84 assessable bleeds; investigators judged overall pdFX efficacy to be excellent or good for all subjects. Turkish subjects had 51 adverse events; 96% with known severity were mild/moderate, and 1 (infusion-site pain) was possibly pdFX-related. These results demonstrate that 25 IU/kg pdFX is safe and effective in this Turkish cohor

Use of a High-Purity Factor X Concentrate in Turkish Subjects with Hereditary Factor X Deficiency: Post Hoc Cohort Subanalysis of a Phase 3 Study

WOS: 000433166100006PubMed ID: 29545231Hereditary factor X (FX) deficiency is a rare bleeding disorder more prevalent in countries with high rates of consanguineous marriage. In a prospective, open-label, multicenter phase 3 study, 25 IU/kg plasma-derived factor X (pdFX) was administered as on-demand treatment or short-term prophylaxis for 6 months to 2 years. In Turkish subjects (n=6), 60.7% of bleeds were minor. A mean of 1.03 infusions were used to treat each bleed, and mean total dose per bleed was 25.38 IU/kg. Turkish subjects rated pdFX efficacy as excellent or good for all 84 assessable bleeds; investigators judged overall pdFX efficacy to be excellent or good for all subjects. Turkish subjects had 51 adverse events; 96% with known severity were mild/moderate, and 1 (infusion-site pain) was possibly pdFX-related. These results demonstrate that 25 IU/kg pdFX is safe and effective in this Turkish cohortBio Products Laboratory (Elstree, UK)Bio Products Laboratory (Elstree, UK) provided support for this study and funding for medical writing and editorial support in the development of this manuscript. A.F.O.: Received educational support from Pfizer. M.N.: Employee of Bio Products Laboratory. K.K.: Advisory board member for Bayer, Novo Nordisk, Pfizer, and Shire; received educational and investigational support from Bayer, Bio Products Laboratory, CSL Behring, Novo Nordisk, Octapharma, Pfizer, and Shire

As a Rare Site of Invasive Fungal Infection, Chronic Granulomatous Aspergillus Synovitis: A Case Report

Aspergillus can causes invasive disease of various organs especially in patients with weakened immune systems. Aspergillus synovitis and arthritis are uncommon types of involvement due to this infection. Approches to fungal osteoarticular infections are based on only case reports. This paper presents a rare case of chronic granulomatous Aspergillus synovitis in an immunocompromised 5-year old girl who was treated for acute lymphoblastic leukemia

Synthesis, characterization and biological application of dinuclear Cu(II) complexes of Schiff base ligands of galactochloralose and alpha-chloralose

WOS: 000445543100014Four novel dinuclear Cu(II) complexes (1a-4a) have been prepared from ONO-tridentate chiral Schiff base derivatives of chloralose (1-4). All the new complexes (1a-4a) have been characterized by Fourier transform infrared spectroscopy, UV-visible spectroscopy and elemental analysis. The complex 2a was further characterized by X-Ray crystallography. And also, the magnetic susceptibility measurement of this complex (2a, mu(eff) 2.61 BM/dimer) was measured at room temperature. The activities of ONO-tridentate chiral Schiff base derivatives of chloralose (1-4) and their dinuclear Cu(II) complexes (1a-4a) on viability of human cervical cancer cell line (HeLa) were investigated by MIT assay. The obtained results indicated that the Schiff base ligand 1 and its dinuclear Cu(II) complex (1a) have excellent cytotoxic activity. Also, dinuclear Cu(II) complexes of the galactochloralose and alpha-chloralose derivative Schiff base ligands were screened for their in vitro antimicrobial activity against eight bacterial species as well as yeast species Candida albicans ATCC 10231 using disc diffusion method. Complex 4a exhibited promising in vitro antimicrobial activity with inhibition zone diameter from 10 to 22 mm against the tested Gram-positive bacterial strains and yeast C. albicans.Ege UniversityEge University [2014 FEN 071]We would like to Ege University for financial support of this work (2014 FEN 071) and Associate Prof. Dr. Serpil Denizalti for carrying out the magnetic susceptibility measurement