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Equilibrium Vortex Motion in Two-·and Three-Dimensional Superconductors Studied with a dc SQUID
Effects of the Burrowing Brittlestar, Microphiopholis gracillima (Echinodermata: Ophiuroidea), on the Flux of Lithium, an Inert Tracer, Across the Sediment-Water Interface
Burrowing and ventilation activities of infaunal organisms have been shown to affect geochemical processes in sediments and at the sediment-water interface. Although burrowing brittlestars are dominant in many benthic environments, their role in these processes is poorly known. We tested the effect of the amphiurid brittlestar, Microphiopholis gracillima, on the flux of lithium ion from the sediment to the overlying water by using sediment cores with false bottoms for continuous flow of a Li+1-seawater solution. Brittlestars at densities of 300 and 600 individuals m-2 caused a twofold increase in the rate that Li was transported through the sediment. Density of brittlestars appeared to have no effect on the flux of Li+1 from the sediment, indicating a possible threshold beyond which density increases do not influence fluxes of solute from the sediment
Peeling Bifurcations of Toroidal Chaotic Attractors
Chaotic attractors with toroidal topology (van der Pol attractor) have
counterparts with symmetry that exhibit unfamiliar phenomena. We investigate
double covers of toroidal attractors, discuss changes in their morphology under
correlated peeling bifurcations, describe their topological structures and the
changes undergone as a symmetry axis crosses the original attractor, and
indicate how the symbol name of a trajectory in the original lifts to one in
the cover. Covering orbits are described using a powerful synthesis of kneading
theory with refinements of the circle map. These methods are applied to a
simple version of the van der Pol oscillator.Comment: 7 pages, 14 figures, accepted to Physical Review
Accelerated Calvarial Healing in Mice Lacking Toll-Like Receptor 4
The bone and immune systems are closely interconnected. The immediate inflammatory response after fracture is known to trigger a healing cascade which plays an important role in bone repair. Toll-like receptor 4 (TLR4) is a member of a highly conserved receptor family and is a critical activator of the innate immune response after tissue injury. TLR4 signaling has been shown to regulate the systemic inflammatory response induced by exposed bone components during long-bone fracture. Here we tested the hypothesis that TLR4 activation affects the healing of calvarial defects. A 1.8 mm diameter calvarial defect was created in wild-type (WT) and TLR4 knockout (TLR4-/-) mice. Bone healing was tested using radiographic, histologic and gene expression analyses. Radiographic and histomorphometric analyses revealed that calvarial healing was accelerated in TLR4-/- mice. More bone was observed in TLR4-/- mice compared to WT mice at postoperative days 7 and 14, although comparable healing was achieved in both groups by day 21. Bone remodeling was detected in both groups on postoperative day 28. In TLR4-/- mice compared to WT mice, gene expression analysis revealed that higher expression levels of IL-1β, IL-6, TNF-α,TGF-β1, TGF-β3, PDGF and RANKL and lower expression level of RANK were detected at earlier time points (≤ postoperative 4 days); while higher expression levels of IL-1β and lower expression levels of VEGF, RANK, RANKL and OPG were detected at late time points (> postoperative 4 days). This study provides evidence of accelerated bone healing in TLR4-/- mice with earlier and higher expression of inflammatory cytokines and with increased osteoclastic activity. Further work is required to determine if this is due to inflammation driven by TLR4 activation. © 2012 Wang et al
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