ANALYSIS OF EFFECTIVENESS OF USE OF BIORESORBABLE PLATES ON THE BASIS OF COLLAGEN AND DIGESTASE FOR TREATMENT OF INFLAMMATORY DISEASES OF PARODENTIUM IN ADOLESCENTS

This article describes results of use of bioresorbable plates on the basis of collagen and digestase “Farmadont” as an anti-inflammatory drug being a part of a complex therapy for treatment of chronic generalized gingivitis in adolescents. Results of evaluation show a high effectiveness of use of the collagenic plates. Keywords: gingivitis, collagen, digestase, plates “Farmadont”, adolescents

Assessment of groundwater quality and their vulnerability to pollution using GQI and DRASTIC indices

Surface and groundwater resources are two important sources in meeting agricultural, urban, and industrial needs. Random supply of surface water resources has prevented these resources from being a reliable source of water supply at all times. Therefore, groundwater acts as insurance in case of water shortage, and maintaining the quality of these resources is very important. On the other hand, studying vulnerability and identifying areas prone to aquifer pollution seems necessary for the development and optimal management of these valuable resources. Identifying the vulnerabilities of the aquifer areas to pollution will lead to a greater focus on preserving those areas. Therefore, groundwater quality assessment was performed in this study using the groundwater quality index (GQI), and groundwater vulnerability to pollution was assessed using the DRASTIC index. GQI is developed based on the values of six quality parameters (Na+, Mg2+, Ca2+, SO42-, Cl-, and TDS). The DRASTIC index is developed based on the values of seven parameters (depth to the water table, net recharge, aquifer media, soil media, topography, impact of vadose zone, hydraulic conductivity). The zoning of both indexes has been done using geographic information system (GIS) software. The results show that the GQI of the region was about 93, and its DRASTIC index was about 86. Therefore, the quality of aquifer groundwater is excellent, and its vulnerability to pollution is low

Blockade of HIF-1α and STAT3 by hyaluronate-conjugated TAT- chitosan-SPION nanoparticles loaded with siRNA molecules prevents tumor growth

HIF-1α and STAT3 are two of the critical factors in the growth, proliferation, and metastasis of cancer cells and play a crucial role in inhibiting anti-cancer immune responses. Therefore, we used superparamagnetic iron oxide (SPION) nanoparticles (NPs) coated with thiolated chitosan (ChT) and trimethyl chitosan (TMC) and functionalized with hyaluronate (H) and TAT peptide for delivery of siRNA molecules against STAT3 and HIF-1α to cancer cells both in vivo and in vitro. The results indicated that tumor cell transfection with siRNAencapsulated NPs robustly inhibited proliferation and migration and induced apoptosis in tumor cells. Furthermore, simultaneous silencing of HIF-1α and STAT3 significantly repressed cancer development in two different tumor types (4T1 breast cancer and CT26 colon cancer) which were associated with upregulation of cytotoxic T lymphocytes and IFN-γ secretion. The findings suggest inhibiting the HIF-1α/ STAT3 axis by SPION-TMC-ChT-TAT-H NPs as an effective way to treat cancer