Проблемы вещно-правовой защиты права собственности

The aim of the study is to evaluate the property rights protection system in the civil law system of the Russian Federation. The author present the law instruments that owner and possessor are entitled to by focusing on the law regulation and judicature

Monte Carlo simulation of streamflow of the Salt River, Arizona

EXTRACT (SEE PDF FOR FULL ABSTRACT): Evaluations of the impact of climate change (such as a greenhouse effect) upon water resources should represent both the expected change and the uncertainty in that expectation. Since water resources such as streamflow and reservoir levels depend on a variety of factors, each of which is subject to significant uncertainty, it is desirable to formulate methods of representing that uncertainty in the forcing factors and from this determine the uncertainty in the response variables of interest. We report here progress in the representation of the uncertainty in climate upon the uncertainty in the estimated hydrologic response

Elaboration of New Method of Deep Processing of Caro-tene-containing Raw Materials Into Nanoadditives with the Use of Cryogenic Freezing and Fine-dispersed Grinding

The aim of the work is elaboration of principally new cryogenic method of deep processing of carotene-containing vegetable raw material (CCVRM) such as carrot, pumpkin, sweet Bulgarian pepper, tomato, sea buckthorn, apricot using cryogenic freezing and fine-dispersed grinding.The new method of deep processing leads to more full extracting and removal of β-carotene from the state, bound with biopolymers into free and hydrophilic form. The mechanism of these processes was presented. It was established, that mass share of β-carotene in cryopuree, received by the new method, exceeds its content in initial (fresh) CCVRM in 3,0…3,5 times.The regularities of growth and transformation of carotenoids separately at freezing with different high speeds and low-temperature grinding of CCYRM were established. It was demonstrated, that at cryogenic freezing take place quantitative increase of mass share of carotenoids in 2,0…2,5 times comparing with initial (fresh) raw material depending on freezing speed and type of CCVRM. That is it was demonstrated, that frozen carotene-containing vegetable raw material contains 2,0…2,5 times more β-carotene than fresh one. Mechanism of these processes was presented.It was demonstrated, that cryopuree of CCVRM, received using new methods of deep processing, exceeds the initial (fresh) raw material by the content not only β-carotene but also other low-molecular bioactive substances: L-ascorbic acid – in 2,0…2,2 times, phenol compounds – in 1,7…1,8 times, tanning substances – in 1,5…1,7 times). That is they have principally new chemical composition, because practically all bioactive substances (BAS) in cryopuree are in nanosize form and easily assimilated by human organism

ELABORATION OF NEW METHOD OF DEEP PROCESSING OF CARO-TENE-CONTAINING RAW MATERIALS INTO NANOADDITIVES WITH THE USE OF CRYOGENIC FREEZING AND FINE-DISPERSED GRINDING

The aim of the work is elaboration of principally new cryogenic method of deep processing of carotene-containing vegetable raw material (CCVRM) such as carrot, pumpkin, sweet Bulgarian pepper, tomato, sea buckthorn, apricot using cryogenic freezing and fine-dispersed grinding. The new method of deep processing leads to more full extracting and removal of β-carotene from the state, bound with biopolymers into free and hydrophilic form. The mechanism of these processes was presented. It was established, that mass share of β-carotene in cryopuree, received by the new method, exceeds its content in initial (fresh) CCVRM in 3,0…3,5 times. The regularities of growth and transformation of carotenoids separately at freezing with different high speeds and low-temperature grinding of CCYRM were established. It was demonstrated, that at cryogenic freezing take place quantitative increase of mass share of carotenoids in 2,0…2,5 times comparing with initial (fresh) raw material depending on freezing speed and type of CCVRM. That is it was demonstrated, that frozen carotene-containing vegetable raw material contains 2,0…2,5 times more β-carotene than fresh one. Mechanism of these processes was presented. It was demonstrated, that cryopuree of CCVRM, received using new methods of deep processing, exceeds the initial (fresh) raw material by the content not only β-carotene but also other low-molecular bioactive substances: L-ascorbic acid – in 2,0…2,2 times, phenol compounds  – in 1,7…1,8 times, tanning substances – in 1,5…1,7 times). That is they have principally new chemical composition, because practically all bioactive substances (BAS) in cryopuree are in nanosize form and easily assimilated by human organism

NOAA local climate analysis tool (LCAT) data, methods, and usability

The National Oceanic and Atmospheric Administration (NOAA) has responded to the increased demand for local climate information by developing the Local Climate Analysis Tool (LCAT). The tool provides rapid responses to climate questions that historically required an extensive data search, research on appropriate analysis techniques, and complex graphics packages. LCAT offers easy and efficient access to scientifically sound analytical capabilities and trusted climate data. Results obtained from LCAT provide relevant climate information to local technical users, decision makers, and educators that will help build a healthy nation and create resilient communities. To ensure that LCAT responds to the articulated needs for local climate studies, a team of representatives from the NWS field offices routinely collects and ranks needs for capabilities to be incorporated into LCAT. The team also helps to design the LCAT user interface and provides training on the tool\u27s features, methods, and usability. The LCAT framework offers analyses of climate change impacts, climate variability impacts, and correlation

Comparative Analysis of Clinical and Functional Results and Position of Intraocular Lens after Femtolaser-Assisted and Standard Cataract Phacoemulsification

Modern surgical treatment of cataracts provides effective results. The study of the position of the intraocular lens (IOL) in the capsule bag can be considered as one of the most important factors influencing the final visual and refractive result of the operation.Aim: comparative analysis of clinical and functional results and position of the IOL in the capsular bag, namely decentration and tilt, when performing femtolazer-assisted phacoemulsification (FLACS) and standard phacoemulsification (CPCS). Materials and methods. We surveyed 57 patients (57 eyes). FLACS was performed in 27 patients, CPCS – in 30 patients. Standard methods of research were used, determination of the position of the IOL (decentration and tilt) in the capsular bag on the device OCT-Casia2 (TOMEY, Germany) and study of wave front were conducted.Results. Comparative analysis of the obtained results showed no significant difference between groups in postoperative visual acuity, however, there was the trend towards higher performance corrected distance visual acuity and uncorrected distance in the group FLACS (0.68 ± 0.18 and 0.74 ± 0.2) compared to the group CPCS (0.58 ± 0.28 and 0.65 ± 0.24). Internal higher order aberrations were significantly low in the group with femtolazer accompaniment: in 3 mm zone almost 2 times (p = 0.041), in 5 mm zone 1.3 times (p = 0.047). Vertical decentration in a CPCS group made 0.217 ± 0.26 mm, in FLACS group – 0.118 ± 0.05 mm, the vertical tilt – 0.75 ± 0.37° and 0.54 ± 0.36 respectively. Conclusion. Decentralizations and IOL tilt tended to lower indices in the FLACS during the observation period up to 2 months after the operation, which was accompanied by lower values of higher order internal aberrations

Modern views about reproductive health and potential in women with HIV infection and viral blood-borne hepatitis

The article presents a review of literature devoted to the epidemiology of HIV infection in the world and Russia, as well as the investigation of reproductive disorders in women with HIV infection and viral blood-borne hepatitis. Actuality of the problem lies in the fact that grows the number of HIV infected and having blood-borne viral hepatitis with involvement in the epidemiological process people of reproductive age, and especially the increase in the number of HIV-infected women of childbearing age. Importantly, it is necessary to predict, diagnose and correct reproductive disorders in women, taking into account basic patterns and risk factors for the formation of such violations with a view to the restoration and preservation of reproductive capacity and ability to have healthy children

THE NEW METHOD OF PROCESSING OF CAROTENE-CONTAINING VEGETABLES FOR THE PRODUCTION OF NANOPRODUCTS USING COMBI-STEAMERS AND FINE-DISPERSED COMMINUTION

The aim of the work is elaboration of the principally new method of deep processing of carotene-containing vegetables (CCV). For attaining this aim was used the complex effect of steam-thermal processing and fine-dispersed comminution for preservation and extraction of biologically active substances from the raw material and getting products of nanosized form. There was also used the new generation of equipment: combi-steamer and dine-dispersed comminutor.  There was elaborated the new method of deep processing, alternative to cryogenic one. This method is based on the complex effect of steam-thermal processing and fine-disperse comminution using the modern equipment (combi-steamer and fine-dispersed comminutor) that is used at enterprises of restaurant business. This method allows use biological potential of the raw material more fully (2…3 times more) and get the foodstuff in nanoform. It was shown, that at steam-thermal processing of vegetables (carrot, pumpkin) in combi-steam antioxidant enzymatic processes flow with less intensity (3…4times less) than at blanching. It was established, that at the steam-thermal processing in combi-steamer in 10 minutes in carotene-containing vegetables takes place not only conservation of β-carotene but also increase of its mass fraction in 2…2,5 times (comparing with initial raw material). Mechanism of this process is connected with fact that carotenoids are transformed from the hidden state (frms associated with biopolymers) into free form that is fixed by chemical methods. It was also established, that after steam-thermal processing and fine-dispersed comminution of carotene-containing vegetables at preparation of puree takes place the significant increase of extraction of ascorbic acid and β-carotene comparing with initial raw material that is for pumpkin 2 and 3 times more and for carrot 1,7 and 2,5 times more, respectively. It was established, that complex use of the new equipment at steam-thermal processing of vegetable raw material in combi-steamer with fine-dispersed comminution gives a possibility to get puree, which quality is approximated to the one of puree, received using cryogenic processing of product (especially, by the content of β-carotene and other biologically active substances (BAS).&nbsp

Lys98 Substitution in Human AP Endonuclease 1 Affects the Kinetic Mechanism of Enzyme Action in Base Excision and Nucleotide Incision Repair Pathways

Human apurinic/apyrimidinic endonuclease 1 (APE1) is a key enzyme in the base excision repair (BER) and nucleotide incision repair (NIR) pathways. We recently analyzed the conformational dynamics and kinetic mechanism of wild-type (wt) protein, in a stopped-flow fluorescence study. In this study, we investigated the mutant enzyme APE1K98A using the same approach. Lys98 was known to hydrogen bond to the carboxyl group of Asp70, a residue implicated in binding the divalent metal ion. Our data suggested that the conformational selection and induced fit occur during the enzyme action. We expanded upon the evidence that APE1 can pre-exist in two conformations. The isomerization of an enzyme-product complex in the BER process and the additional isomerization stage of enzyme-substrate complex in the NIR process were established for APE1K98A. These stages had not been registered for the wtAPE1. We found that the K98A substitution resulted in a 12-fold reduction of catalytic constant of 5′-phosphodiester bond hydrolysis in (3-hydroxytetrahydrofuran-2-yl)methyl phosphate (F, tetrahydrofuran) containing substrate, and in 200-fold reduction in 5,6-dihydrouridine (DHU) containing substrate. Thus, the K98A substitution influenced NIR more than BER. We demonstrated that the K98A mutation influenced the formation of primary unspecific enzyme-substrate complex in a complicated manner, depending on the Mg2+ concentration and pH. This mutation obstructed the induced fit of enzyme in the complex with undamaged DNA and F-containing DNA and appreciably decreased the stability of primary complex upon interaction of enzyme with DNA, containing the natural apurinic/apyrimidinic (AP) site. Furthermore, it significantly delayed the activation of the less active form of enzyme during NIR and slowed down the conformational conversion of the complex of enzyme with the cleavage product of DHU-substrate. Our data revealed that APE1 uses the same active site to catalyze the cleavage of DHU- and AP-substrates

THE NEW METHOD OF PROCESSING OF CAROTENE-CONTAINING VEGETABLES FOR THE PRODUCTION OF NANOPRODUCTS USING COMBI-STEAMERS AND FINE-DISPERSED COMMINUTION

The aim of the work is elaboration of the principally new method of deep processing of carotene-containing vegetables (CCV). For attaining this aim was used the complex effect of steam-thermal processing and fine-dispersed comminution for preservation and extraction of biologically active substances from the raw material and getting products of nanosized form. There was also used the new generation of equipment: combi-steamer and dine-dispersed comminutor. There was elaborated the new method of deep processing, alternative to cryogenic one. This method is based on the complex effect of steam-thermal processing and fine-disperse comminution using the modern equipment (combi-steamer and fine-dispersed comminutor) that is used at enterprises of restaurant business. This method allows use biological potential of the raw material more fully (2…3 times more) and get the foodstuff in nanoform.It was shown, that at steam-thermal processing of vegetables (carrot, pumpkin) in combi-steam antioxidant enzymatic processes flow with less intensity (3…4times less) than at blanching.It was established, that at the steam-thermal processing in combi-steamer in 10 minutes in carotene-containing vegetables takes place not only conservation of β-carotene but also increase of its mass fraction in 2…2,5 times (comparing with initial raw material). Mechanism of this process is connected with fact that carotenoids are transformed from the hidden state (frms associated with biopolymers) into free form that is fixed by chemical methods.It was also established, that after steam-thermal processing and fine-dispersed comminution of carotene-containing vegetables at preparation of puree takes place the significant increase of extraction of ascorbic acid and β-carotene comparing with initial raw material that is for pumpkin 2 and 3 times more and for carrot 1,7 and 2,5 times more, respectively.It was established, that complex use of the new equipment at steam-thermal processing of vegetable raw material in combi-steamer with fine-dispersed comminution gives a possibility to get puree, which quality is approximated to the one of puree, received using cryogenic processing of product (especially, by the content of β-carotene and other biologically active substances (BAS).