Chronic myeloid leukemia associated with early lymphoblastic crisis

University of Medicine and Pharmacy of Targu Mures, RomaniaBackground. The blastic crisis of chronic myeloid leukemia (CML-BC) is usually the final phase of the disease, in which the percentage of the young, often undifferentiated cells, known as blastocytes gets above 20%. Nowadays, in the era of the therapy with Tyrosine Kinase Inhibitors, the transformation from CML to CML-BC occurs much later and more rarely

Delineation of hydrocarbon contaminants with multi-frequency complex conductivity imaging

The characterization of contaminated sites is a serious issue that requires a number of techniques to be deployed in the field to reconstruct the geometry, hydraulic properties and state of contamination of the shallow subsurface, often at the hundreds of meter scale with metric resolution. Among the techniques that have been proposed to complement direct investigations (composed of drilling, sampling, and laboratory characterization) are geophysical methods, which can provide extensive spatial coverage both laterally and at depth with the required resolution. However, geophysical methods only measure physical properties that are indirectly related to contamination, and their correlation may be difficult to ascertain without direct ground truth. In this study, we present a successful example where the results of complex conductivity measurements conducted in an imaging framework are compared with direct evidence of subsoil contamination at a jet fuel impacted site. Thus, proving that a combination of direct and indirect investigations can be successfully used to image a site in its complex (potentially 3D) structure in order to build a reliable conceptual model of the site

Intraventricular hemorrhage with subsequent ventriculomegaly in preterm infants

University of Medicine and Pharmacy of Targu MuresBackground. Preterm infants are at risk for developing many perinatal complications such as intraventricular haemorrhage (IVH) and subsequent ventriculomegaly. Babies born before 32 weeks of pregnancy present an even higher risk for IVH, an important cause of severe cognitive and motor neurologic impairment in very low birth weight infants. The risk of IVH is inversely related to gestational age and birth weight

Switching the little kids lives on

University of Medicine and Pharmacy of Targu MuresBackground. Cormatrix is an innovation in bioengineering, introduced in the medical world in 2013. The material is based on the extracellular matrix derived from the porcine intestine submucosa, allowing for tissue restructure and growth in the "site" where it is used. The composition consists of collagen, glycosaminoglycans, glycoproteins, proteoglycans and growth factors VEGF, FGF. The superior characteristics are given by acellularity, resistance to infection, anti-inflammatory effect and immunomodulator, the most important element being the reactivity depending on the impulse from the tissue where it is involved

Myeloid proliferation associated with Down syndrome: a case report

University of Medicine and Pharmacy of Targu Mures, RomaniaBackground. Atypical chronic myeloid leukemia (aCML), BCR-ABL1 negative is a rare myelodysplastic syndrome (MDS)/myeloproliferative neoplasm (MPN) for which no current standard of care exists. ACML is characterized by many clinical features (splenomegaly, myeloid predominance in the bone marrow with some dysplastic features but without a differentiation block) and laboratory abnormalities (myeloid proliferation, low leukocyte alkaline phosphate values). A review of the literature suggests that the presence of an abnormal chromosome 21 may predispose to the development of leukemia

Treatment of chronic lymphocytic leukemia – a difficult choice for severe complications: a case report

University of Medicine and Pharmacy of Targu MuresBackground. Chronic lymphocytic leukemia (CLL) is the most common form of adult leukemia in the western European countries and is characterized by the relentless accumulation of monoclonal B cells with the appearance of small mature lymphocytes and with a characteristic immunophenotype. Even with the right treatment, this disease is known to have a variable course: some patients die within one year after diagnosis while others live for longer than ten years

Partial 13 monosomy with corpus callosum agenesis and other congenital abnormalities – a case report

University of Medicine and Pharmacy of Targu Mures, RomaniaBackground. The corpus callosum comprises the largest tract of nerve fibres in the human brain. It is developed from the telencephalon starting in the 11th week of foetal life. Partial or complete agenesis of the corpus callosum is a rare developmental anomaly of unknown cause. A case of corpus callosum agenesis is described

Spontaneous pneumothorax after a respiratory distress syndrome – a case report

University of Medicine and Pharmacy of Targu MuresBackground. Respiratory distress syndrome(RDS) of the newborn is caused by pulmonary surfactant deficiency in the lungs of neonates which leads to alveolar collapse and noncompliant lungs. It can be primary or secondary, due to meconium aspiration or Group B Streptocoocus (GBS) infection. RDS is usually diagnosed with a combination of clinical signs and/or symptoms (apnea, cyanosis, grunting, inspiratory stridor, nasal flaring, poor feeding, and tachypnea), chest radiographic findings, and arterial blood gas Results. In near term or term infants with great respiratory effort, RDS can be complicated with spontaneous pnumothorax

Estimation of wind speed over lakes in Central Europe using spaceborne C-band SAR

The Sentinel-1 satellite mission provides high-resolution, all-weather, day and night Synthetic Aperture Radar images. Studies about wind parameters above the ocean are frequent, inland lakes were seldom investigated. The objective of this article is to investigate the potential of C-band SAR for wind retrieval over lakes for evaluation of representativeness of meteorological station data. A number of lakes from Austria and Hungary (lakes in Salzkammergut, Lake Neusiedl and Lake Balaton), where wind measurements from automatic weather stations are available from the surroundings, has been selected for this study. Functions for speed retrieval are developed from empirical relationships for both available polarizations, VV and VH. Meteorological station data are used for calibration and validation. Best results were obtained for VV although with a dependency on incidence angle. Functions for different incidence angles according to the wind speed were, therefore, determined. There is a good correlation between the measured and the calculated wind speed (R of 0.71–0.91 for calibration sites; average R 0.71 for all sites). Average wind speed patterns for the lakes can be derived, but need to be analyzed separately for descending and ascending acquisitions due to difference in daytime (morning versus late afternoon).9219311