1,232 research outputs found
Assessment of HER2 and Ki67 in adenocarcinomas
Biomarkers in tumor tissue can predict cancer behavior or can be targeted with targeted therapy. Two examples of such biomarkers are HER2 and Ki67. These biomarkers are assessed with stains on tissue of patients in clinical pathology.Timco Koopman is a resident in pathology and works at the pathology department of the UMCG. For his thesis he researched the quantitative assessment of HER2 and Ki67 in malignant tumors of glandular tissue (adenocarcinomas). HER2 is a receptor protein that is best known from breast and stomach cancer. Anti-HER2-therapy for HER2-positive tumors of these organs can increase a patient’s chances of curation and survival. Ki67 is a protein that is present in dividing cells. As such, quantification of Ki67 reflects the growth speed and aggressiveness of tumors.The first part of the thesis is about HER2. Koopman explored the prevalence of HER2-positivity in gastric and esophageal cancer and describes how HER2 should be determined in these tumors. Koopman also describes why assessment of HER2 in other tumors than breast, stomach or esophagus can be more problematic.The second part of the thesis is about digital image analysis. Digitizing in modern pathology is on the rise. Digitized images can be analyzed with specific software. Koopman describes why digital image analysis in clinical pathology will benefit the reliability and reproducibility of the assessment of HER2 and Ki67
High-pressure Dielectric Properties Of Perovskite Ferroelectrics Related To The Earth\u27s Mantle
Resonant photon absorption and hole burning in Cr7Ni antiferromagnetic rings
Presented are magnetization measurements on a crystal of Cr7Ni
antiferromagnetic rings. Irradiation with microwaves at frequencies between 1
and 10 GHz leads to observation of very narrow resonant photon absorption lines
which are mainly broadened by hyperfin interactions. A two-pulse hole burning
technique allowed us to estimate the characteristic energy diffusion time.Comment: 4 pages, 5 figure
A cationic and ferromagnetic hexametallic Mn(III) single-molecule magnet based on the salicylamidoxime ligand
Will spin-relaxation times in molecular magnets permit quantum information processing?
Using X-band pulsed electron spin resonance, we report the intrinsic
spin-lattice () and phase coherence () relaxation times in molecular
nanomagnets for the first time. In Cr heterometallic wheels, with = Ni
and Mn, phase coherence relaxation is dominated by the coupling of the electron
spin to protons within the molecule. In deuterated samples reaches 3
s at low temperatures, which is several orders of magnitude longer than
the duration of spin manipulations, satisfying a prerequisite for the
deployment of molecular nanomagnets in quantum information applications.Comment: 4 pages, 3 figures, in press at Physical Review Letter
Assessment of HER2 and Ki67 in adenocarcinomas
Biomarkers in tumor tissue can predict cancer behavior or can be targeted with targeted therapy. Two examples of such biomarkers are HER2 and Ki67. These biomarkers are assessed with stains on tissue of patients in clinical pathology. Timco Koopman is a resident in pathology and works at the pathology department of the UMCG. For his thesis he researched the quantitative assessment of HER2 and Ki67 in malignant tumors of glandular tissue (adenocarcinomas). HER2 is a receptor protein that is best known from breast and stomach cancer. Anti-HER2-therapy for HER2-positive tumors of these organs can increase a patient’s chances of curation and survival. Ki67 is a protein that is present in dividing cells. As such, quantification of Ki67 reflects the growth speed and aggressiveness of tumors. The first part of the thesis is about HER2. Koopman explored the prevalence of HER2-positivity in gastric and esophageal cancer and describes how HER2 should be determined in these tumors. Koopman also describes why assessment of HER2 in other tumors than breast, stomach or esophagus can be more problematic. The second part of the thesis is about digital image analysis. Digitizing in modern pathology is on the rise. Digitized images can be analyzed with specific software. Koopman describes why digital image analysis in clinical pathology will benefit the reliability and reproducibility of the assessment of HER2 and Ki67
Assessment of HER2 and Ki67 in adenocarcinomas
Biomarkers in tumor tissue can predict cancer behavior or can be targeted with targeted therapy. Two examples of such biomarkers are HER2 and Ki67. These biomarkers are assessed with stains on tissue of patients in clinical pathology. Timco Koopman is a resident in pathology and works at the pathology department of the UMCG. For his thesis he researched the quantitative assessment of HER2 and Ki67 in malignant tumors of glandular tissue (adenocarcinomas). HER2 is a receptor protein that is best known from breast and stomach cancer. Anti-HER2-therapy for HER2-positive tumors of these organs can increase a patient’s chances of curation and survival. Ki67 is a protein that is present in dividing cells. As such, quantification of Ki67 reflects the growth speed and aggressiveness of tumors. The first part of the thesis is about HER2. Koopman explored the prevalence of HER2-positivity in gastric and esophageal cancer and describes how HER2 should be determined in these tumors. Koopman also describes why assessment of HER2 in other tumors than breast, stomach or esophagus can be more problematic. The second part of the thesis is about digital image analysis. Digitizing in modern pathology is on the rise. Digitized images can be analyzed with specific software. Koopman describes why digital image analysis in clinical pathology will benefit the reliability and reproducibility of the assessment of HER2 and Ki67
g-engineering in hybrid rotaxanes to create AB and AB2 electron spin systems: EPR spectroscopic studies of weak interactions between dissimilar electron spin qubits
Hybrid [2]rotaxanes and pseudorotaxanes are reported where the magnetic interaction between dissimilar spins is controlled to create AB and AB2 electron spin systems,allowing independent control of weakly interacting S =1=2 centers
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