Southeast Atlantic Ocean aerosol direct radiative effects over clouds: Comparison of observations and simulations

This is the final version. Available from AIP Publishing via the DOI in this recordAbsorbing aerosols exert a warming or a cooling effect on the Earth's system, depending on the circumstances. The direct radiative effect (DRE) of absorbing aerosols is negative (cooling) at the top-of-the-atmosphere (TOA) over a dark surface like the ocean, as the aerosols increase the planetary albedo, but it is positive (warming) over bright backgrounds like clouds. Furthermore, radiation absorption by aerosols heat the atmosphere locally, and, through rapid adjustments of the atmospheric column and cloud dynamics, the net effect can be amplified considerably. We developed a technique to study the absorption of radiation of smoke over low lying clouds using satellite spectrometry. The TOA DRE of smoke over clouds is large and positive over the southeast Atlantic Ocean off the west coast of Africa, which can be explained by the large decrease of reflected radiation by a polluted cloud, especially in the UV. However, general circulation models (GCMs) fail to reproduce these strong positive DRE, and in general GCMs disagree on the magnitude and even sign of the aerosol DRE in the southeast Atlantic region. Our satellite-derived DRE measurements show clear seasonal and inter-annual variations, consistent with other satellite measurements, which are not reproduced by GCMs. A comparison with model results showed discrepancies with the Ångström exponent of the smoke aerosols, which is larger than assumed in simulations, and a sensitivity to emission scenarios. However, this was not enough to explain the discrepancies, and we suspect that the modeling of cloud distributions and microphysics will have the necessary larger impact on DRE that will explain the differences between observations and modeling.Netherlands Space Offic

Molecular and Clinical Analyses of Greig Cephalopolysyndactyly and Pallister-Hall Syndromes: Robust Phenotype Prediction from the Type and Position of GLI3 Mutations

Mutations in the GLI3 zinc-finger transcription factor gene cause Greig cephalopolysyndactyly syndrome (GCPS) and Pallister-Hall syndrome (PHS), which are variable but distinct clinical entities. We hypothesized that GLI3 mutations that predict a truncated functional repressor protein cause PHS and that functional haploinsufficiency of GLI3 causes GCPS. To test these hypotheses, we screened patients with PHS and GCPS for GLI3 mutations. The patient group consisted of 135 individuals: 89 patients with GCPS and 46 patients with PHS. We detected 47 pathological mutations (among 60 probands); when these were combined with previously published mutations, two genotype-phenotype correlations were evident. First, GCPS was caused by many types of alterations, including translocations, large deletions, exonic deletions and duplications, small in-frame deletions, and missense, frameshift/nonsense, and splicing mutations. In contrast, PHS was caused only by frameshift/nonsense and splicing mutations. Second, among the frameshift/nonsense mutations, there was a clear genotype-phenotype correlation. Mutations in the first third of the gene (from open reading frame [ORF] nucleotides [nt] 1-1997) caused GCPS, and mutations in the second third of the gene (from ORF nt 1998-3481) caused primarily PHS. Surprisingly, there were 12 mutations in patients with GCPS in the 3\u27 third of the gene (after ORF nt 3481), and no patients with PHS had mutations in this region. These results demonstrate a robust correlation of genotype and phenotype for GLI3 mutations and strongly support the hypothesis that these two allelic disorders have distinct modes of pathogenesis

Southeast Atlantic Ocean aerosol direct radiative effects over clouds: comparison of observations and simulations

Absorbing aerosols exert a warming or a cooling effect on the Earth’s system, depending on the circumstances. The direct radiative effect (DRE) of absorbing aerosols is negative (cooling) at the top-of-the-atmosphere (TOA) over a dark surface like the ocean, as the aerosols increase the planetary albedo, but it is positive (warming) over bright backgrounds like clouds. Furthermore, radiation absorption by aerosols heat the atmosphere locally, and, through rapid adjustments of the atmospheric column and cloud dynamics, the net effect can be amplified considerably. We developed a technique to study the absorption of radiation of smoke over low lying clouds using satellite spectrometry. The TOA DRE of smoke over clouds is large and positive over the southeast Atlantic Ocean off the west coast of Africa, which can be explained by the large decrease of reflected radiation by a polluted cloud, especially in the UV. However, general circulation models (GCMs) fail to reproduce these strong positive DRE, and in general GCMs disagree on the magnitude and even sign of the aerosol DRE in the southeast Atlantic region. Our satellite-derived DRE measurements show clear seasonal and inter-annual variations, consistent with other satellite measurements, which are not reproduced by GCMs. A comparison with model results showed discrepancies with the Ångström exponent of the smoke aerosols, which is larger than assumed in simulations, and a sensitivity to emission scenarios. However, this was not enough to explain the discrepancies, and we suspect that the modeling of cloud distributions and microphysics will have the necessary larger impact on DRE that will explain the differences between observations and modeling

Molecular Analysis Expands the Spectrum of Phenotypes Associated with GLI3 Mutations

A range of phenotypes including Greig cephalopolysyndactyly and Pallister-Hall syndromes (GCPS, PHS) are caused by pathogenic mutation of the GLI3 gene. To characterize the clinical variability of GLI3 mutations, we present a subset of a cohort of 174 probands referred for GLI3 analysis. Eighty-one probands with typical GCPS or PHS were previously reported, and we report the remaining 93 probands here. This includes 19 probands (12 mutations) who fulfilled clinical criteria for GCPS or PHS, 48 probands (16 mutations) with features of GCPS or PHS but who did not meet the clinical criteria (sub-GCPS and sub-PHS), 21 probands (6 mutations) with features of PHS or GCPS and oral-facial-digital syndrome, and 5 probands (1 mutation) with nonsyndromic polydactyly. These data support previously identified genotype-phenotype correlations and demonstrate a more variable degree of severity than previously recognized. The finding of GLI3 mutations in patients with features of oral-facial-digital syndrome supports the observation that GLI3 interacts with cilia. We conclude that the phenotypic spectrum of GLI3 mutations is broader than that encompassed by the clinical diagnostic criteria, but the genotype-phenotype correlation persists. Individuals with features of either GCPS or PHS should be screened for mutations in GLI3 even if they do not fulfill clinical criteria

Cultural Competence with Humility Using Interprofessional Multicultural Learning Activities: Student Perceptions

This study examined students’ perceptions of interprofessional multicultural learning activities used to develop cultural competence with humility (CCH). Limited research exists on student perceptions of learning activities for CCH in entry-level occupational therapy educational programs. This exploratory, mixed methods study used an anonymous online survey, the Learning Activities Survey (LAS), to collect student quantitative ratings and qualitative feedback about CCH learning activities and their experience within the Counselors and Occupational Therapists Professionally Engaged in the Community (COPE) program. A deductive thematic approach was used by two investigators for qualitative analyses of COPE learning activities by alignment in four a priori CCH constructs: cultural awareness, cultural knowledge, cultural skills, and cultural desire. Consensus was gained through discussion. Nineteen of 29 (65.5%) students completed the survey. The mean score on the LAS for 6 of 12 activities (50%) was at least Moderately important (mean ≥ 3.0) to student learning. Twelve of 19 students (63%) rated 11 of 12 learning activities as Moderately important (mean ≥ 3.0). Qualitatively, cognitive knowledge was the strongest reported CCH learning construct within the COPE program with a frequency of 32. The combined quantitative and qualitative responses indicated the learning activities positively influenced students’ learning of CCH. This study may inform occupational therapy curricular activities that satisfy accreditation requirements and expectations of the profession to meet the cultural needs of society. It also provides support for revisions to occupational therapy educational program standards to better align with recent literature

Analytical Approach to the One-Dimensional Disordered Exclusion Process with Open Boundaries and Random Sequential Dynamics

A one dimensional disordered particle hopping rate asymmetric exclusion process (ASEP) with open boundaries and a random sequential dynamics is studied analytically. Combining the exact results of the steady states in the pure case with a perturbative mean field-like approach the broken particle-hole symmetry is highlighted and the phase diagram is studied in the parameter space $(\alpha,\beta)$, where $\alpha$ and $\beta$ represent respectively the injection rate and the extraction rate of particles. The model displays, as in the pure case, high-density, low-density and maximum-current phases. All critical lines are determined analytically showing that the high-density low-density first order phase transition occurs at $\alpha \neq \beta$. We show that the maximum-current phase extends its stability region as the disorder is increased and the usual $1/\sqrt{\ell}$-decay of the density profile in this phase is universal. Assuming that some exact results for the disordered model on a ring hold for a system with open boundaries, we derive some analytical results for platoon phase transition within the low-density phase and we give an analytical expression of its corresponding critical injection rate $\alpha^*$. As it was observed numerically$^{(19)}$, we show that the quenched disorder induces a cusp in the current-density relation at maximum flow in a certain region of parameter space and determine the analytical expression of its slope. The results of numerical simulations we develop agree with the analytical ones.Comment: 23 pages, 7 figures. to appear in J. Stat. Phy

Sex and Gender-Based Women\u27s Health: A Practical Guide for Primary Care - A Resource for Learning and Teaching

TOP WINNER Background: Patients expect comprehensive, gender-specific care; yet studies reveal that few residency programs in internal medicine provide dedicated training in women’s health and gender-based medicine. Further, graduates are unable to demonstrate competency to care for female and gender-diverse patients. Objectives: To produce a sex and gender-based women’s health curriculum, written explicitly for primary care providers to guide the care of women and gender-diverse patients, and to be used as a curriculum to educate learners. Methods: In collaboration with Springer Nature, development of this online and inprint textbook began in 2017. Topics were chosen with input from women’s health experts and are tailored to gender-based conditions commonly evaluated, diagnosed, and/or managed in the primary care setting. Authors were then recruited nationally for each topic. Using evidenced-based medicine principles, chapters were formatted for consistency to include the epidemiology, physiology/pathophysiology, clinical manifestations, differential diagnosis, diagnostic approach, and treatment for each topic, when appropriate. Each chapter has clear, measurable learning objectives, summary statements, and multiplechoice questions with annotated answers to check understanding and help earn CME and MOC credit. With 39 chapters and \u3e600 pages, sections are comprehensive and include Breast and Gynecologic Health and Disease, Obstetric Medicine, Chronic Pain Disorders, Mental Health and Trauma, LGBTQ Health, Common Medical Conditions (osteoporosis, cardiovascular disease), and Foundations of Women’s Health, which highlights the history, disparities, and future of women’s and gender-based healthcare. Conclusions/Impact: This is the first comprehensive curricular resource written by clinical women’s health physicians, using the most up-to-date evidence, clinical guidelines, expert opinion, and clinical pearls. Our goal is to provide a guide that can serve as a quick point-of-care clinical reference for a specific topic or as a longitudinal curriculum for learners in any primary care discipline, especially programs where women’s health and gender-specific curricula and champions are sparse.https://jdc.jefferson.edu/sexandgenderhealth/1030/thumbnail.jp

Stochastic boundary conditions in the deterministic Nagel-Schreckenberg traffic model

We consider open systems where cars move according to the deterministic Nagel-Schreckenberg rules and with maximum velocity ${v}_{max} > 1$, what is an extension of the Asymmetric Exclusion Process (ASEP). It turns out that the behaviour of the system is dominated by two features: a) the competition between the left and the right boundary b) the development of so-called "buffers" due to the hindrance an injected car feels from the front car at the beginning of the system. As a consequence, there is a first-order phase transition between the free flow and the congested phase accompanied by the collapse of the buffers and the phase diagram essentially differs from that of ${v}_{max} = 1$ (ASEP).Comment: 29 pages, 26 figure

The effects of HIV and systolic blood pressure on mortality risk in rural South Africa, 2010-2019: a data note

Objectives: South Africa is experiencing both HIV and hypertension epidemics. Data were compiled for a study to identify effects of HIV and high systolic blood pressure on mortality risk among people aged 40-plus in a rural South African area experiencing high prevalence of both conditions. We aim to release the replication data set for this study. Data description: The research data comes from the 2010-11 Ha Nakekela (We Care) population-based survey nested in the Agincourt Health and socio-Demographic Surveillance System (AHDSS) located in the northeast region of South Africa. An age-sex-stratified probability sample was drawn from the AHDSS. The public data set includes information on individual socioeconomic characteristics and measures of HIV status and blood pressure for participants aged 40-plus by 2019. The AHDSS, through its annual surveillance, provided mortality data for nine years subsequent to the survey. These data were converted to person-year observations and linked to the individual-level survey data using participants’ AHDSS census identifier. The data can be used to replicate Houle et al. (2022) — which used discrete-time event history models stratified by sex to assess differential mortality risks according to Ha Nakekela measures of HIV-infection, HIV-1 RNA viral load, and systolic blood pressure

Aerosol direct radiative effect of smoke over clouds over the southeast Atlantic Ocean from 2006 to 2009

The aerosol direct radiative effect (DRE) of African smoke was analyzed in cloud scenes over the southeast Atlantic Ocean, using Scanning Imaging Absorption Spectrometer for Atmospheric Chartography (SCIAMACHY) satellite observations and Hadley Centre Global Environmental Model version 2 (HadGEM2) climate model simulations. The observed mean DRE was about 30–35 W m−2 in August and September 2006–2009. In some years, short episodes of high-aerosol DRE can be observed, due to high-aerosol loadings, while in other years the loadings are lower but more prolonged. Climate models that use evenly distributed monthly averaged emission fields will not reproduce these high-aerosol loadings. Furthermore, the simulated monthly mean aerosol DRE in HadGEM2 is only about 6 W m−2 in August. The difference with SCIAMACHY mean observations can be partly explained by an underestimation of the aerosol absorption Ångström exponent in the ultraviolet. However, the subsequent increase of aerosol DRE simulation by about 20% is not enough to explain the observed discrepancy between simulations and observations