22 research outputs found
Autologous hematopoietic cell transplantation for relapsed multiple myeloma performed with cells procured after previous transplantation–study on behalf of CMWP of the EBMT
Autologous hematopoietic cell transplantation (auto-HCT) may be performed in multiple myeloma (MM) patients relapsing after a previous auto-HCT. For those without an adequate dose of stored stem cells, remobilization is necessary. This retrospective study included patients who, following disease relapse after the first auto-HCT(s), underwent stem cell remobilization and auto-HCT performed using these cells. There were 305 patients, 68% male, median age at salvage auto-HCT was 59 years. The median time to relapse after the first-line penultimate auto-HCT(s) was 30.6 months, the median follow-up after salvage auto-HCT 31 months. The 2- and 4-year non-relapse mortality (NRM) after the salvage auto-HCT was 5 and 9%, the relapse incidence 56 and 76%, respectively. Overall survival (OS) after 2 and 4 years was 76 and 52%, progression-free survival (PFS) 39 and 15%. In multivariable analysis an increasing interval between the penultimate auto-HCT and relapse was associated with better OS and PFS, later calendar year of salvage auto-HCT with better OS. In conclusion, salvage auto-HCT performed with cells remobilized after a previous auto-HCT was associated with acceptable NRM. The leading cause of failure was disease progression of MM, which correlated with a shorter interval from the penultimate auto-HCT to the first relapse
Back to basics: improving the conceptualization and operationalization of programmatic exposure in social and behavior change communication through conceptual models.
Reaching the Global Community During Disasters: Findings From a Content Analysis of the Organizational Use of Twitter After the 2010 Haiti Earthquake.
It depends on your pocket: Findings from a qualitative study in Uganda exploring women\u27s and health care providers\u27 perspectives on family planning
Disconnect between discourse and behavior regarding concurrent sexual partnerships and condom use: findings from a qualitative study among youth in Malawi
Effectiveness of mHealth behavior change communication interventions in developing countries: A systematic review of the literature
Reflections on the potential of mHealth to strengthen health systems in low- and middle-income countries
Waking Up the Mind: Qualitative Study Findings About the Process Through Which Programs Combining Income Generation and Health Education Can Empower Indigenous Guatemalan Women.
‘I can’t leave everything in the hands of my husband’: Economic constraints and gender roles in care-seeking in post-Ebola Guinea
The 2014–2016 Ebola epidemic in West Africa had enduring effects on health systems and healthcare utilisation. This study explores the intersection of economic constraints and gender roles in Guinea to understand delays in care-seeking post-Ebola. In-depth interviews (n = 45) and focus group discussions (n = 24) were conducted with mothers, male heads of household, grandmothers, and health workers in rural and urban areas in Basse-Guinée and Guinée Forestière. A thematic analysis identified salient themes related to gender and economic constraints on health care-seeking. Participants, particularly men, emphasised the high cost of seeking care, which led to delays as women secured funds. Men’s engagement in care-seeking included providing funds and permission, picking up medication, and giving appointment reminders. As principal actors when ‘navigating’ the healthcare system, women were intimately involved in economic decisions and responsible for securing funds for services – even when lacking direct financial control. Essentialist descriptions of men as ‘providers’ and women as ‘navigators’, therefore, masked nuances in care-seeking and economic responsibilities. Programmes must acknowledge men’s engagement in care-seeking and address both the economic barriers women face when seeking care and their economic roles. Greater attention to the complex intersection of economic constraints and gender roles could address care-seeking delays