Adaptation and delimitation: some thoughts about the Kanurization of the Gamergu

The area around the Lake Chad is characterized as an example for a region where ethnic changes abundantly took place and still do. For example some Kanuri districts, or the leaders of those districts, are (unofficially) named after other ethnic names (e.g. Margi, Shuwa) or Kanuri clan names are identical with ethnic names of other groups, eg. Tera, Bade. Both people speak a Chadic language and live in the south and west of the Kanuri respectively. These are indications that the Kanuri formerly absorbed and integrated these peoples. These processes are not only a phenomenon of the past. In the case of the neighbouring Gamergu people an ongoing process of ethnic change towards a Kanuri identity is observed until present. The research projects1 have revealed that the concept of "ethnic units" is far from being static which the term may suggest. This especially applies to the German Stamm, which implies a static concept of ethnicity. However, in Borno the dynamics of ethnic and linguistic change are prevailing. Therefore Ronald Cohen rejected the term "ethnic unit", or even "tribe" for the Kanuri and preferred "nation" instead. Umara Bulakarima argued along the same line but used "ethnic group" for Kanuri subunits, e.g. Manga, Mowar, Suwurti. There is no doubt that the Kanuri played a dominant part in the history of the Lake Chad area during the past centuries. Therefore the "Kanurization" process may not surprise. However, in the following it will be revealed that the processes of contact and resulting adaptations and delimitations are not necessarily unidirectional from Kanuri to other groups. At least in some cases they may go into the opposite direction, e.g. from Gamergu to Kanuri

Safety assessments of subcutaneous doses of aragonite calcium carbonate nanocrystals in rats

Calcium carbonate nanoparticles have shown promising potentials in the delivery of drugs and metabolites. There is however, a paucity of information on the safety of their intentional or accidental over exposures to biological systems and general health safety. To this end, this study aims at documenting information on the safety of subcutaneous doses of biogenic nanocrystals of aragonite polymorph of calcium carbonate derived from cockle shells (ANC) in Sprague-Dawley (SD) rats. ANC was synthesized using the top-down method, characterized using the transmission electron microscopy and field emission scanning electron microscope and its acute and repeated dose 28-day trial toxicities were evaluated in SD rats. The results showed that the homogenous 30 ± 5 nm-sized spherical pure aragonite nanocrystals were not associated with mortality in the rats. Severe clinical signs and gross and histopathological lesions, indicating organ toxicities, were recorded in the acute toxicity (29,500 mg/m2) group and the high dose (5900 mg/m2) group of the repeated dose 28-day trial. However, the medium- (590 mg/m2 body weight) and low (59 mg/m2)-dose groups showed moderate to mild lesions. The relatively mild lesions observed in the low toxicity dosage group marked the safety margin of ANC in SD rats. It was concluded from this study that the toxicity of CaCO3 was dependent on the particulate size (30 ± 5 nm) and concentration and the route of administration used

Formulation of a sustained release docetaxel loaded cockle shell-derived calcium carbonate nanoparticles against breast cancer

Purpose: Here, we explored the formulation of a calcium carbonate nanoparticle delivery system aimed at enhancing docetaxel (DTX) release in breast cancer. Methods: The designed nano- anticancer formulation was characterized thorough X-ray diffraction (XRD), Fourier transformed infrared (FTIR), transmission electron microscopy (TEM) and field emission scanning electron microscopy (FESEM) and Brunauer-Emmett-Teller (BET) methods. The nano- anticancer formulation (DTX- CaCO3NP) was evaluated for drug delivery properties thorough in vitro release study in human body simulated solution at pH 7.4 and intracellular lysosomal pH 4.8. Results: Characterization revealed the successful synthesis of DTX- CaCO3NP, which had a sustained release at pH 7.4. TEM showed uniformly distributed pleomorphic shaped pure aragonite particles. The highest entrapment efficiency (96%) and loading content (11.5%) were obtained at docetaxel to nanoparticles ratio of 1:4. The XRD patterns revealed strong crystallizations in all the nanoparticles formulation, while FTIR showed chemical interactions between the drug and nanoparticles with negligible positional shift in the peaks before and after DTX loading. BET analysis showed similar isotherms before and after DTX loading. The designed DTX- CaCO3NP had lower (p 0.05) effects at 48 h and 72 h. However, the DTX- CaCO3NP released less than 80% of bond DTX at 48 and 72 h but showed comparable effects with free DTX. Conclusions: The results showed that the developed DTX- CaCO3NP released DTX slower at pH 7.4 and had comparable cytotoxicity with free DTX at 48 and 72 h in MCF-7 cells

Cultural Sustainability, Performance and the Sustainable Development Goals in Time of Crisis

Cultural Sustainability, Performance and the Sustainable Development Goals in Time of Crisis is an essential cultural tapestry that responds meaningfully well to human critical needs in time of crisis, especially in North East Nigeria and other troubled spots in Nigeria and West Africa. The book is broad and engaging in its coverage of cultural sustainability, and rests comfortably on the three pillars of culture in sustainability, culture for sustainability, and culture as sustainability. e work offers pragmatic roadmap for navigating the four key thematic concerns and aspirations for creating the Sustainable Development Goals (SDGs): peace, freedom, development, and environment. These are reflected in action-oriented case studies that permeate the book. The work is organic in scholarly comprehension, interpretative and issues oriented, and foresightful on cultural and performance sustainability. It’s a dependable roadmap to cultural and performing sustainability, conflict dissection and resolution in time of crisis