1 research outputs found
Bifunctional Phase Transfer Catalysis in the Asymmetric Synthesis of Biologically Active Isoindolinones
New bifunctional chiral ammonium salts were investigated in an asymmetric cascade synthesis of a key building block for a variety
of biologically relevant isoindolinones. With this chiral compound in hand, the development of further transformations allowed for
the synthesis of diverse derivatives of high pharmaceutical value, such as the Belliotti (S)-PD172938 and arylated analogues with
hypnotic sedative activity, obtained in good overall total yield (50%) and high enantiomeric purity (95% ee). The synthetic routes
developed herein are particularly convenient in comparison with the current methods available in literature and are particularly
promising for large scale applications