2,148 research outputs found

    CRFM Consultancy Report on Review of Existing Policy, Legal and Institutional Arrangements for Governance and Management of Flyingfish Fisheries in the Caribbean Large Marine Ecosystem

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    Many of the marine resources in the Caribbean are considered to be fully or overexploited. A Transboundary Diagnostic Analysis identified three priority transboundary problems that affect the CLME: unsustainable exploitation of fish and other living resources, the degradation and modification of natural habitats, pollution and contamination. The fourwing flyingfish fishery is the single most important small pelagic fishery in the southern Lesser Antilles. It is a shared resource, which has been traditionally exploited by seven different States, i.e. Barbados, Dominica, Grenada, Martinique, Saint Lucia, Saint Vincent and the Grenadines and Trinidad and Tobago. With expanding fleet capacity and limited cooperation among the States exploiting the flyingfish, there is concern that the resource may become overfished. While the flyingfish fishery is a directed fishery, it is at the same time part of a multi-species, multi-gear fishery, which also targets regional large pelagic species.This case study identifies and analyses the priority transboundary problems and issues. The policy, legal and institutional reforms needed to address such transboundary issues and achieve long-term conservation and sustainable use of the resources are also identified. A major and necessary component of the case study is an evaluation of the existing policy cycles and linkages among the countries and institutions involved with the flyingfish fishery

    The currency of talent management - a reply to "talent management and the relevance of context: towards a pluralistic approach"

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    In this paper we provide a commentary on the article in this special issue by Thunnissen, Boselie, and Fruytier on the relevance of context to the field of talent management. We agree that further research is needed to explore the link between macro, meso and micro-level considerations. The authors pose a question in relation to the contribution of talent management to the social and moral development of society; which, for us, raises issues as to the extent to which individual agency in ethical issues is possible in environments designed to regulate and control talent. We concur that a more critical, pluralist approach to talent management scholarship is needed and that talent management should go beyond a mere economic exchange. We suggest, as Yet unexplored, notions of strategic exchange, and individual identity provide a richer picture of the employment relationship. Thus this paper raises a number of possible directions for future TM research

    Impaired nutrient signaling and body weight control in a Naâș neutral amino acid cotransporter (Slc6a19)-deficient mouse

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    Amino acid uptake in the intestine and kidney is mediated by a variety of amino acid transporters. To understand the role of epithelial neutral amino acid uptake in whole body homeostasis, we analyzed mice lacking the apical broad-spectrum neutral (0) amino acid transporter BᎌAT1 (Slc6a19). A general neutral aminoaciduria was observed similar to human Hartnup disorder which is caused by mutations in SLC6A19. Naâș -dependent uptake of neutral amino acids into the intestine and renal brush-border membrane vesicles was abolished. No compensatory increase of peptide transport or other neutral amino acid transporters was detected. Mice lacking BᎌAT1 showed a reduced body weight. When adapted to a standard 20% protein diet, BᎌAT1-deficient mice lost body weight rapidly on diets containing 6 or 40% protein. Secretion of insulin in response to food ingestion after fasting was blunted. In the intestine, amino acid signaling to the mammalian target of rapamycin (mTOR) pathway was reduced, whereas the GCN2/ATF4 stress response pathway was activated, indicating amino acid deprivation in epithelial cells. The results demonstrate that epithelial amino acid uptake is essential for optimal growth and body weight regulation.This work was supported by National Health and Medical Research Council Grant 525415, Australian Research Council Grant DP0877897, University of Sydney Bridging Grant RIMS2009-02579), and by an anonymous foundatio

    Bottleneck size and selection level reproducibly impact evolution of antibiotic resistance

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    During antibiotic treatment, the evolution of bacterial pathogens is fundamentally affected by bottlenecks and varying selection levels imposed by the drugs. Bottlenecks—that is, reductions in bacterial population size—lead to an increased influence of random effects (genetic drift) during bacterial evolution, and varying antibiotic concentrations during treatment may favour distinct resistance variants. Both aspects influence the process of bacterial evolution during antibiotic therapy and thereby treatment outcome. Surprisingly, the joint influence of these interconnected factors on the evolution of antibiotic resistance remains largely unexplored. Here we combine evolution experiments with genomic and genetic analyses to demonstrate that bottleneck size and antibiotic-induced selection reproducibly impact the evolutionary path to resistance in pathogenic Pseudomonas aeruginosa, one of the most problematic opportunistic human pathogens. Resistance is favoured—expectedly—under high antibiotic selection and weak bottlenecks, but—unexpectedly—also under low antibiotic selection and severe bottlenecks. The latter is likely to result from a reduced probability of losing favourable variants through drift under weak selection. Moreover, the absence of high resistance under low selection and weak bottlenecks is caused by the spread of low-resistance variants with high competitive fitness under these conditions. We conclude that bottlenecks, in combination with drug-induced selection, are currently neglected key determinants of pathogen evolution and outcome of antibiotic treatment

    Ferromagnetism in defect-ridden oxides and related materials

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    The existence of high-temperature ferromagnetism in thin films and nanoparticles of oxides containing small quantities of magnetic dopants remains controversial. Some regard these materials as dilute magnetic semiconductors, while others think they are ferromagnetic only because the magnetic dopants form secondary ferromagnetic impurity phases such as cobalt metal or magnetite. There are also reports in d0 systems and other defective oxides that contain no magnetic ions. Here, we investigate TiO2 (rutile) containing 1 - 5% of iron cations and find that the room-temperature ferromagnetism of films prepared by pulsed-laser deposition is not due to magnetic ordering of the iron. The films are neither dilute magnetic semiconductors nor hosts to an iron-based ferromagnetic impurity phase. A new model is developed for defect-related ferromagnetism which involves a spin-split defect band populated by charge transfer from a proximate charge reservoir in the present case a mixture Fe2+ and Fe3+ ions in the oxide lattice. The phase diagram for the model shows how inhomogeneous Stoner ferromagnetism depends on the total number of electrons Ntot, the Stoner exchange integral I and the defect bandwidth W; the band occupancy is governed by the d-d Coulomb interaction U. There are regions of ferromagnetic metal, half-metal and insulator as well as nonmagnetic metal and insulator. A characteristic feature of the high-temperature Stoner magnetism is an an anhysteretic magnetization curve which is practically temperature independent below room temperature. This is related to a wandering ferromagnetic axis which is determined by local dipole fields. The magnetization is limited by the defect concentration, not by the 3d doping. Only 1-2 % of the volume of the films is magnetically ordered.Comment: 22 pages, 6 figure
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