Bilateral Fronto-Parietal Integrity in Young Chronic Cigarette Smokers: A Diffusion Tensor Imaging Study

Cigarette smoking continues to be the leading cause of preventable morbidity and mortality in China and other countries. Previous studies have demonstrated gray matter loss in chronic smokers. However, only a few studies assessed the changes of white matter integrity in this group. Based on those previous reports of alterations in white matter integrity in smokers, the aim of this study was to examine the alteration of white matter integrity in a large, well-matched sample of chronic smokers and non-smokers.Using in vivo diffusion tensor imaging (DTI) to measure the differences of whole-brain white matter integrity between 44 chronic smoking subjects (mean age, 28.0±5.6 years) and 44 healthy age- and sex-matched comparison non-smoking volunteers (mean age, 26.3±5.8 years). DTI was performed on a 3-Tesla Siemens scanner (Allegra; Siemens Medical System). The data revealed that smokers had higher fractional anisotropy (FA) than healthy non-smokers in almost symmetrically bilateral fronto-parietal tracts consisting of a major white matter pathway, the superior longitudinal fasciculus (SLF).We found the almost symmetrically bilateral fronto-parietal whiter matter changes in a relatively large sample of chronic smokers. These findings support the hypothesis that chronic cigarette smoking involves alterations of bilateral fronto-parietal connectivity

Analysis of road network pattern considering population distribution and central business district.

This paper proposes a road network growing model with the consideration of population distribution and central business district (CBD) attraction. In the model, the relative neighborhood graph (RNG) is introduced as the connection mechanism to capture the haracteristics of road network topology. The simulation experiment is set up to illustrate the effects of population distribution and CBD attraction on the characteristics of road network. Moreover, several topological attributes of road network is evaluated by using coverage, circuitness, treeness and total length in the experiment. Finally, the suggested model is verified in the simulation of China and Beijing Highway networks

Review of history and research on airport collaborative decision making

The airport collaborative decision making can effectively improve the operational efficiency of airports， so as to improve the operational efficiency of the whole civil aviation transportation network. The relevant standards，policy files and research papers of collaborative decision making are compiled in this paper. The development history of in airports and the current situation of research and application on collaborative decision making in academia and industry，both in China and abroad are collated. The future development trend of collaborative decision making in airports and the challenges faced by collaborative decision making in the current period are discussed and analyzed. Some suggestions for the development of collaborative decision making in airports based on the actual situation in China are given. The theoretical support and basis for improving the operational efficiency and economic benefits of airports and the whole air transportation network are summarized. The study in this paper can provide theoretical support and basis for operational efficiency and economic efficiency of the whole air traffic network

Joint analysis of the spatial impacts of built environment on car ownership and travel mode choice

Concerns over transportation energy consumption and emissions have prompted more studies into the impacts of built environment on driving-related behavior, especially on car ownership and travel mode choice. This study contributes to examine the impacts of the built environment on commuter\u27s driving behavior at both spatial zone and individual levels. The aim of this study is threefold. First, a multilevel integrated multinomial logit (MNL) and structural equation model (SEM) approach was employed to jointly explore the impacts of the built environment on car ownership and travel mode choice. Second, the spatial context in which individuals make the travel decisions was accommodated, and spatial heterogeneities of car ownership and travel mode choice across traffic analysis zones (TAZs) were recognized. Third, the indirect effects of the built environment on travel mode choice through the mediating variable car ownership were calculated, in other words, the intermediary nature of car ownership was considered. Using the Washington metropolitan area as the study case, the built environment measures were calculated for each TAZ, and the commuting trips were drawn from the household travel survey in this area. To estimate the model parameters, the robust maximum likelihood (MLR) method was used. Meanwhile, a comparison among different model structures was conducted. The model results suggest that application of the multilevel integrated MNL and SEM approach obtains significant improvements over other models. This study give transportation planners a better understanding on how the built environment influences car ownership and commuting mode choice, and consequently develop effective and targeted countermeasures

Aberrant Default Mode Functional Connectivity in Early Onset Schizophrenia

Background: The default mode network (DMN) has been linked to a number of mental disorders including schizophrenia. However, the abnormal connectivity of DMN in early onset schizophrenia (EOS) has been rarely reported.Methods: Independent component analysis (ICA) was used to investigate functional connectivity (FC) of the DMN in 32 first-episode adolescents with EOS and 32 age and gender-matched healthy controls.Results: Compared to healthy controls, patients with EOS showed increased FC between the medial frontal gyrus and other areas of the DMN. Partial correlation analyses showed that the FC of medial frontal gyrus significantly correlated with PANSS-positive symptoms (partial correlation coefficient  = 0.538, Bonferoni corrected P = 0.018).Limitations: Although the sample size of participants was comparable with most fMRI studies to date, it was still relatively small. Pediatric brains were registered to the MNI adult brain template. However, possible age-specific differences in spatial normalization that arise from registering pediatric brains to the MNI adult brain template may have little effect on fMRI results.Conclusion: This study provides evidence for functional abnormalities of DMN in first-episode EOS. These abnormalities could be a source of abnormal introspectively-oriented mental actives.</p