Disorder-induced linear magnetoresistance in Al2_2O3_3/SrTiO3_3 heterostructures

The unsaturated linear magnetoresistance (LMR) has attracted widely attention because of potential applications and fundamental interest. By controlling the growth temperature, we realized the metal-to-insulator transition in Al$_2$O$_3$/SrTiO$_3$ heterostructures. The LMR is observed in metallic samples with the electron mobility varying over three orders of magnitude. The observed LMR cannot be explained by the guiding center diffusion model even in samples with very high mobility. The slope of the observed LMR is proportional to the Hall mobility, and the crossover field, indicating a transition from quadratic (at low fields) to linear (at high fields) field dependence, is proportional to the inverse Hall mobility. This signifies that the classical model is valid to explain the observed LMR. More importantly, we develop an analytical expression according to the effective-medium theory that is equivalent to the classical model. And the analytical expression describes the LMR data very well, confirming the validity of the classical model.Comment: 22 Pages, 4 figures, 1 tabl

A structure-preserving doubling algorithm for quadratic eigenvalue problems arising from time-delay systems

AbstractWe propose a structure-preserving doubling algorithm for a quadratic eigenvalue problem arising from the stability analysis of time-delay systems. We are particularly interested in the eigenvalues on the unit circle, which are difficult to estimate. The convergence and backward error of the algorithm are analyzed and three numerical examples are presented. Our experience shows that our algorithm is efficient in comparison to the few existing approaches for small to medium size problems

Cordycepin reverses cisplatin resistance in human bladder cancer cells via the PTEN/PI3K/AKt pathway

Purpose: To study the influence of cordycepin (Cor) on cisplatin insensitivity in bladder carcinoma, and its underlying mechanism of action.Methods: The effects of cisplatin and Cor treatments on the viability of T24-sensitive and T24/DDPinsensitive bladder carcinoma cells were investigated by using 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) method to assess selectivity index. Flow cytometry was employed to evaluate the apoptosis of T24/DDP-resistant bladder cancer cells treated with cisplatin and Cor. The concentrations of PTEN, p-AKt and Akt in T24/DDP-resistant bladder cancer cells treated with cisplatin and Cor were determined by western blot assay.Results: Compared with T24-sensitive cells, the sensitivity of T24/DDP-resistant bladder cancer cells to cisplatin was significantly decreased, along with significant increase in half-inhibitory concentration (IC50) value, resulting in 10.56-fold increase in resistance (p < 0.05). The median effective concentration (EC50) value of Cor for DDP reversal was 1.03 ± 0.15 μM, and it had a high selectivity index for normal cells (> 48.5). The results from flow cytometry showed that Cor significantly enhanced the apoptosisinducing capacity of DDP in T24/DDP-resistant cells (p < 0.05), while Western blot data indicate that PTEN protein expression increased and phosphorylated Akt protein expression decreased in T24/DDPresistantcells after Cor treatment when compared with control group (p < 0.05).Conclusion: Cordycepin significantly improves the sensitivity of T24/ DDP-resistant bladder cancer cells to cisplatin via a mechanism related to the activation of PTEN/AKt signaling pathway, thus indicating that it is a potential candidate reversing DDP-resistance in bladder cancer. Keywords: Bladder cancer, Cordycepin, Cisplatin resistance, PTEN/Akt signaling pathwa

Compensation effect in carbon nanotube quantum dots coupled to polarized electrodes in the presence of spin-orbit coupling

We study theoretically the Kondo effect in carbon nanotube quantum dot attached to polarized electrodes. Since both spin and orbit degrees of freedom are involved in such a system, the electrode polarization contains the spin- and orbit-polarizations as well as the Kramers polarization in the presence of the spin-orbit coupling. In this paper we focus on the compensation effect of the effective fields induced by different polarizations by applying magnetic field. The main results are i) while the effective fields induced by the spin- and orbit-polarizations remove the degeneracy in the Kondo effect, the effective field induced by the Kramers polarization enhances the degeneracy through suppressing the spin-orbit coupling; ii) while the effective field induced by the spin-polarization can not be compensated by applying magnetic field, the effective field induced by the orbit-polarization can be compensated; and iii) the presence of the spin-orbit coupling does not change the compensation behavior observed in the case without the spin-orbit coupling. These results are observable in an ultraclean carbon-nanotube quantum dot attached to ferromagnetic contacts under a parallel applied magnetic field along the tube axis and it would deepen our understanding on the Kondo physics of the carbon nanotube quantum dot.Comment: 8 pages, 6 figure