Faulting structure above the Main Himalayan Thrust as shown by relocated aftershocks of the 2015 Mw7.8 Gorkha, Nepal, earthquake

The 25 April 2015, Mw7.8 Gorkha, Nepal, earthquake ruptured a shallow section of the Indian‐Eurasian plate boundary by reverse faulting with NNE‐SSW compression, consistent with the direction of current Indian‐Eurasian continental collision. The Gorkha main shock and aftershocks were recorded by permanent global and regional arrays and by a temporary local broadband array near the China‐Nepal border deployed prior to the Gorkha main shock. We relocate 272 earthquakes with Mw>3.5 by applying a multiscale double‐difference earthquake relocation technique to arrival times of direct and depth phases recorded globally and locally. We determine a well‐constrained depth of 18.5 km for the main shock hypocenter which places it on the Main Himalayan Thrust (MHT). Many of the aftershocks at shallower depths illuminate faulting structure in the hanging wall with dip angles that are steeper than the MHT. This system of thrust faults of the Lesser Himalaya may accommodate most of the elastic strain of the Himalayan orogeny.Key PointsWe relocate the 2015 Gorkha earthquakes using teleseismic and regional waveformsThe main shock is located on the horizontal Main Himalaya Thrust (MHT) at a depth of 18.5 kmAftershocks show faulting structure in the hanging wall above the MHTPeer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135634/1/grl53895.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/135634/2/grl53895_am.pd

Genome-wide analyses identify KLF4 as an important negative regulator in T-cell acute lymphoblastic leukemia through directly inhibiting T-cell associated genes

é 2015 Li et al. Background: Kruppel-like factor 4 (KLF4) induces tumorigenesis or suppresses tumor growth in a tissue-dependent manner. However, the roles of KLF4 in hematological malignancies and the mechanisms of action are not fully understood. Methods: Inducible KLF4-overexpression Jurkat cell line combined with mouse models bearing cell-derived xenografts and primary T-cell acute lymphoblastic leukemia (T-ALL) cells from four patients were used to assess the functional role of KLF4 in T-ALL cells in vitro and in vivo. A genome-wide RNA-seq analysis was conducted to identify genes regulated by KLF4 in T-ALL cells. Chromatin immunoprecipitation (ChIP) PCR was used to determine direct binding sites of KLF4 in T-ALL cells. Results: Here we reveal that KLF4 induced apoptosis through the BCL2/BCLXL pathway in human T-ALL cell lines and primary T-ALL specimens. In consistence, mice engrafted with KLF4-overexpressing T-ALL cells exhibited prolonged survival. Interestingly, the KLF4-induced apoptosis in T-ALL cells was compromised in xenografts but the invasion capacity of KLF4-expressing T-ALL cells to hosts was dramatically dampened. We found that KLF4 overexpression inhibited T cell-associated genes including NOTCH1, BCL11B, GATA3, and TCF7. Further mechanistic studies revealed that KLF4 directly bound to the promoters of NOTCH1, BCL2, and CXCR4 and suppressed their expression. Additionally, KLF4 induced SUMOylation and degradation of BCL11B. Conclusions: These results suggest that KLF4 as a major transcription factor that suppresses the expression of T-cell associated genes, thus inhibiting T-ALL progression.Link_to_subscribed_fulltex

Analysis of the photonic bandgaps for gyrotron devices

The global bandgaps of photonic crystal are theoretically analyzed in this paper. The electromagnetic-wave propagation characteristics of photonic bandgap (PBG) structures, which is used in the the millimeter-wave, submillimeter-wave, and terahertz regime vacuum electronic devices and accelerators, were numerically simulated using the finite-element method software high-frequency structural simulator. The dispersion curves of the lattices in different rod radius to-rod spacing ratios and the global bandgaps for the general 2-D PBG structures formed by triangular and square arrays of metal rods were simulated. A mode map that shows the relationship between the structures and the contained modes was plotted and a 220-GHz metallic PBG resonator operating in TE _{math\rm {math\bf {04}}} mode was designed for a gyrotron device to verify the theoretical and numerical simulations, and a comparison of mode density and quality factor between the PBG resonator and the equivalent cylindrical resonator has been carried out