The Nonlinear Relationship Between Temperature and Prognosis in Sepsis-induced Coagulopathy Patients: A Retrospective Cohort Study from MIMIC-IV Database

Background: The prognostic value of body temperature in sepsis-induced coagulopathy (SIC) remains unclear. In this study we aimed to investigate the association between temperature and mortality among SIC patients. Methods: We analyzed data for 9,860 SIC patients from an intensive care database. Patients were categorized by maximum temperature in the first 24 hours into the following: ≤36.0°C; 36.0–37.0°C; 37.0–38.0°C; 38.0–39.0°C; and ≥39.0°C. The primary outcome was 28-day mortality. We used multivariate regression to analyze the temperature-mortality association. Results: The 37.0–38.0°C, 38.0–39.0°C and ≥39.0°C groups correlated with lower 28-day mortality (adjusted HR 0.70, 0.76 and 0.72, respectively), while the <36.0°C group correlated with higher mortality compared to the 36.0–37.0°C group (adjusted HR 2.60). A nonlinear relationship was observed between temperature and mortality. Subgroup analysis found no effect modification except in cerebrovascular disease. Conclusion: A body temperature in the range of 37.0–38.0°C was associated with a significantly lower mortality compared to the normal temperature (36.0–37.0°C) group. Additionally, a gradual but statistically insignificant increase in mortality risk was observed when body temperature exceeded 38.0°C. Further research should validate these findings and elucidate involved mechanisms, especially in cerebrovascular disease subgroups

A study of the tribological properties of Mo-S-Ti composite films prepared by magnetron sputtering

Pure MoS _2 films exhibit disadvantages such as low densities, poor mechanical properties, and weak wear resistance under atmospheric environments. For this reason, Ti was chosen as the doping element in this work. Mo-S-Ti composite films with different Ti contents were deposited using the magnetron sputtering system, and the effects of Ti content on the chemical composition, mechanical and tribological properties of these films were analyzed by numerous characterization methods to determine the doping content of Ti elements. The results show that the tribological performance of Mo-S-Ti composite film under atmospheric environments reaches the best when the Ti content is 13.48 at%. In addition, the present work also found that longitudinal load and reciprocating frequency have a significant effect on the tribological properties of this film. It is easier to form high quality transfer film on GCr15 balls under higher longitudinal load and lower reciprocating frequency, thus transforming the friction between film and GCr15 ball into the friction between film and transfer film, resulting in excellent tribological performance

The Study on hydrothermal synthesis of ZrO

Nano-ZrO2 has a high atomic active surface and is used as catalyst carrier. The traditional method of preparing ZrO2 nanofibers is electrostatic spinning, which has the problems of high cost and high equipment requirements. In order to solve the shortcomings of traditional preparation methods and prepare excellent ZrO2 nanofibers, a series of ZrO2 nanofibers were prepared based on hydrothermal method by changing the types of reactants, the ratio of reactants to organic additives, solvents, reaction time and other relevant parameters, to explore the growth mechanism of ZrO2 nanofibers, providing a new idea for the preparation of ZrO2 nanofibers on the active surface of altiplano

Production Capacity Evaluation of Farmland Using Long Time Series of Remote Sensing Images

Farmland is a crucial resource for the survival and evolution of humans. The accurate evaluation of farmland production capacity (FPC) is of great significance for planting structure optimization, the improvement of low-yield farmland and sustainable utilization. The objective of this study is to quantitatively evaluate the FPC at the county scale using time series remote sensing (RS) images. Taking winter wheat as a benchmark crop, the relations between annual yield and the Normalized Difference Vegetation Index (NDVI) were established by a multiple linear regression algorithm. The mean and standard deviations (SD) of the multi-year yield of winter wheat were used to evaluate FPC and its instability using the farmland parcels as the basic unit. The results show that the estimation model for annual winter wheat yield performed best in 2011. The R2 of the modeling sample was 0.93, and the RMSE of the testing sample was 368.1 kg/ha. The FPC grades in the south and north of the study area were relatively high with a good stability, while those in the center were low with poor stability. There was a certain correlation between FPC and soil organic matter (SOM), and the correlation coefficient was 0.525 (p < 0.01). In this study, taking the farmland parcel as a basic unit instead of a pixel, long time series of multi-source RS images with medium resolution were used to monitor the per unit yield of benchmark crops and then evaluate the FPC. This can provide a method for the rapid evaluation of FPC at the county scale

Insulin-like growth factor 1-induced enolase 2 deacetylation by HDAC3 promotes metastasis of pancreatic cancer

Enolase 2 (ENO2) is a key glycolytic enzyme in the metabolic process of glycolysis, but its potential function in pancreatic ductal adenocarcinoma (PDAC) is unclear. In this study, we observed a significant overexpression of ENO2 in PDAC tissues, and its expression was correlated with metastasis and poor prognosis in PDAC patients. K394 was identified as a major acetylation site in ENO2 that regulates its enzymatic activity, cell metabolism and PDAC progression. Knockdown of ENO2 suppressed tumor growth and liver metastasis in PDAC. Re-expression of wild-type (WT) ENO2, but not the K394 acetylation mimetic mutant, could reverse the decreased tumor malignancy. We further characterized histone deacetylase 3 (HDAC3) and P300/CBP-associated factor (PCAF) as the potential deacetylase and acetyltransferase for ENO2, respectively. HDAC3-mediated deacetylation was shown to lead to ENO2 activation and enhancement of glycolysis. Importantly, insulin-like growth factor-1 (IGF-1) was found to decrease K394 acetylation and stimulate ENO2 activity in a dose- and time-dependent manner. The PI3K/AKT/mTOR pathway facilitated the phosphorylation of HDAC3 on S424, which promoted K394 deacetylation and activation of ENO2. Linsitinib, an oral small-molecule inhibitor of IGF-1R, could inhibit IGF-1-induced ENO2 deacetylation by HDAC3 and the PI3K/AKT/mTOR pathway. Furthermore, linsitinib showed a different effect on the growth and metastasis of PDAC depending on the overexpression of WT versus K394-mutant ENO2. Our results reveal a novel mechanism by which acetylation negatively regulates ENO2 activity in the metastasis of PDAC by modulating glycolysis. Blockade of IGF-1-induced ENO2 deacetylation represents a promising strategy to prevent the development of PDAC